A5085297785- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Glioma Diagnosis and Treatment
- Evolution and Genetic Dynamics
- Marine Bivalve and Aquaculture Studies
- Environmental Toxicology and Ecotoxicology
- Algorithms and Data Compression
- Chromosomal and Genetic Variations
- Bioinformatics and Genomic Networks
- Parasite Biology and Host Interactions
- Marine animal studies overview
- Microbial Community Ecology and Physiology
- semigroups and automata theory
- Marine Biology and Environmental Chemistry
- Cephalopods and Marine Biology
- Genetics, Bioinformatics, and Biomedical Research
- Chromatin Remodeling and Cancer
- Gene expression and cancer classification
- Developmental Biology and Gene Regulation
- Microplastics and Plastic Pollution
- Environmental and Biological Research in Conflict Zones
- Ocular Oncology and Treatments
- Microtubule and mitosis dynamics
- Advanced Data Storage Technologies
- Ichthyology and Marine Biology
University of Zagreb
2019-2023
Rudjer Boskovic Institute
2013-2022
The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. volvocine green algae a tractable system for understanding the genetic basis including formation cooperative cell groups. Here we report genome sequence undifferentiated colonial alga, Gonium pectorale, where group evolved by co-option retinoblastoma cycle regulatory pathway. Significantly, expression regulator unicellular Chlamydomonas causes it become...
Phylostratigraphy is a computational framework for dating the emergence of DNA and protein sequences in phylogeny. It has been extensively applied to make inferences on patterns genome evolution, including disease gene ontogeny de novo origination. typically relies BLAST searches along species tree, but new simulation studies have raised concerns about ability detect remote homologues its impact phylostratigraphic inferences. Here, we re-assessed these simulations. We found that, even with...
Abstract Background The vertebrate head is a highly derived trait with heavy concentration of sophisticated sensory organs that allow complex behaviour in this lineage. structures arise during development from cranial placodes and the neural crest. It generally thought derivatives these ectodermal embryonic tissues played central role evolutionary transition at onset vertebrates. Despite obvious importance for biology, their history still uncertain. Results To give fresh perspective on...
Abstract Phylostratigraphy is a computational framework for dating the emergence of sequences (usually genes) in phylogeny. It has been extensively applied to make inferences on patterns genome evolution, including disease gene ontogeny and de novo origination. typically relies BLAST searches along species tree, but new simulation studies have raised concerns about ability detect remote homologues its impact phylostratigraphic inferences. These simulations called into question some our...
A collection of intracranial astrocytomas different malignancy grades was analyzed for copy number aberrations (CNA) in order to identify regions that are driving cancer pathogenesis. Astrocytomas were by Array Comparative Genomic Hybridization (aCGH) and bioinformatics utilizing a Bioconductor package, Identification Significant Targets Cancer (GISTIC) 2.0.23 DAVID software. Altogether, 1438 CNA found which losses prevailed. On our total sample, significant deletions affected 14 chromosomal...
Banded murex, Hexaplex trunculus, is a marine gastropod whose reproductive fitness can be severely affected by very low concentrations of antifouling compound tributyltin (TBT). TBT has strong xenoandrogen impacts on snails, causing the development imposex (e.g., superimposition male sexual characteristic in females), thereby affecting entire populations. also known as DNA-demethylating agent and an obesogenic factor. The aim this study was to unravel interactions between bioaccumulation,...
Understanding how phenotypic divergence arises among natural populations remains one of the major goals in evolutionary biology. As part competitive exclusion experiment conducted 1971, 10 individuals Italian wall lizard (Podarcis siculus (Rafinesque-Schmaltz, 1810)) were transplanted from Pod Kopište Island to nearby island Mrčaru (Adriatic Sea). Merely 35 years after introduction, newly established population on had shifted their diet predominantly insectivorous towards omnivorous and...
Abstract Malignancy grades of astrocytomas were analyzed for copy number aberrations by aCGH. Altogether 1438 CNA found which losses prevailed. We searched regions that are more likely to drive cancer pathogenesis with Bioconductor package and Genomic Identification Significant Targets in Cancer. On our total sample significant deletions affected 14 chromosomal regions, out at 17p13.2, 9p21.3, 13q12.11, 22q12.3 remained even 0.05 q-value. When divided malignancy groups, the identified as...
ABSTRACT Haeckel’s biogenetic law, or the recapitulation theory remains a controversial subject to this day. Currently, modern version of law is hourglass model with its phylotypic period. Importantly, nothing more than development, and it does not provide any evidence that ontogeny recapitulates phylogeny. However, are mutually exclusive, there several examples recapitulation-like processes observable after period ontogeny. At level transcriptomics, all attempts demonstrate failed. Using...
A large and ever increasing quantity of high throughput sequencing (HTS) data is stored in FASTQ files. Various methods for compression are used to mitigate the storage transmission costs, from still prevalent general purpose Gzip state-of-the-art specialized methods. However, all existing file require decompression stage before HTS can be used. This particularly costly with random access specific records We propose sFASTQ format, a succinct representation files that without (i.e., retrieved...