A5035210234- Parkinson's Disease Mechanisms and Treatments
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Cellular transport and secretion
- Machine Learning in Bioinformatics
- Retinal Development and Disorders
- Ginkgo biloba and Cashew Applications
- Neurological disorders and treatments
- Insect Pheromone Research and Control
- Aquaculture disease management and microbiota
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Food, Nutrition, and Cultural Practices
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- interferon and immune responses
- Nanocomposite Films for Food Packaging
- HIV Research and Treatment
- biodegradable polymer synthesis and properties
- Neuroscience and Neuropharmacology Research
- Identification and Quantification in Food
- Microplastics and Plastic Pollution
- Biological Research and Disease Studies
- Protein Structure and Dynamics
- Metabolism and Genetic Disorders
Universidade Católica Portuguesa
2024
KU Leuven
2021-2023
Universitätsmedizin Göttingen
2014-2021
VIB-KU Leuven Center for Brain & Disease Research
2020-2021
Vlaams Instituut voor Biotechnologie
2021
University of Lisbon
2014-2016
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103
2014-2015
National Legal Medicine Institute
2015
Instituto de Medicina Molecular João Lobo Antunes
2012-2014
University of Algarve
2008
Parkinson's disease (PD) is the most common representative of a group disorders known as synucleinopathies, in which misfolding and aggregation α-synuclein (a-syn) various brain regions major pathological hallmark. Indeed, motor symptoms PD are caused by heterogeneous degeneration neurons not only substantia nigra pars compacta but also other extrastriatal areas brain. In addition to well dysfunction patients, cognitive deficits memory impairment an important part disorder, probably due...
Aggregation of alpha-synuclein (ASYN) in Lewy bodies and neurites is the typical pathological hallmark Parkinson's disease (PD) other synucleinopathies. Furthermore, mutations gene encoding for ASYN are associated with familial sporadic forms PD, suggesting this protein plays a central role disease. However, precise contribution to neuronal dysfunction death unclear. There intense debate about nature toxic species little known molecular determinants oligomerization aggregation cell. In order...
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. 2 was previously shown modulate proteotoxicity age-associated neurodegenerative disorders such as Alzheimer Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into interplay between sirtuin α-synuclein, major component of pathognomonic protein inclusions in PD other synucleinopathies. We found that α-synuclein is...
Alpha-synuclein (aSyn) misfolding and aggregation are pathological features common to several neurodegenerative diseases, including Parkinson's disease (PD). Mounting evidence suggests that aSyn can be secreted transferred from cell cell, participating in the propagation spreading of events. Rab11, a small GTPase, is an important regulator both endocytic secretory pathways. Here, we show Rab11 involved regulating secretion. knockdown or overexpression either Rab11a wild-type (Rab11a WT)...
Mutations in the genes encoding leucine-rich repeat kinase 2 (LRRK2) and α-synuclein are associated with both autosomal dominant idiopathic forms of Parkinson's disease (PD). α-Synuclein is main protein Lewy bodies, hallmark inclusions present sporadic familial PD. We show that PD brain tissue, levels LRRK2 positively related to increase phosphorylation aggregation affected regions (amygdala anterior cingulate cortex), but not unaffected visual cortex. In disease-affected regions, we...
Materials produced with polybutylene adipate terephthalate (PBAT) and starch are raising great interest for packaging food contact applications, including as support active antimicrobial agents such zinc oxide nanoparticles (ZnO). Studies focusing on the safety of these materials evaluated current reference rules materials, lacking. A commercially available PBAT/starch-based material was incorporated ZnO overall specific migration films were studied at different conditions simulants...
Abstract Human amyloids have been shown to interact with viruses and interfere viral replication. Based on this observation, we employed a synthetic biology approach in which engineered virus-specific against influenza A Zika proteins. Each amyloid shares homologous aggregation-prone fragment specific target protein. For demonstrate that designer PB2 accumulates A-infected tissue vivo. Moreover, acts specifically its common polymorphisms, but not B, lacks the fragment. Our model demonstrates...
Mutations in the MPV17 gene are associated with hepatocerebral form of mitochondrial depletion syndrome. The mechanisms through which mutations cause respiratory chain dysfunction and mtDNA is still unclear. encodes an inner membrane protein that was recently described to function as a non-selective channel. Although its exact unknown, it thought be important maintenance potential (ΔΨm). To obtain more information about role human disease, we investigated effect knockdown selected known...
Abstract It is still unclear why pathological amyloid deposition initiates in specific brain regions, nor cells or tissues are more susceptible than others. Amyloid determined by the self-assembly of short protein segments called aggregation-prone regions (APRs) that favour cross-β structure. Here we investigated whether Aβ assembly can be modified heterotypic interactions between APRs and homologous otherwise unrelated human proteins. We identified accelerate assembly, modify fibril...