A5049222747- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Visual perception and processing mechanisms
- Rocket and propulsion systems research
- Memory and Neural Mechanisms
- Zebrafish Biomedical Research Applications
- Retinal Development and Disorders
- Carcinogens and Genotoxicity Assessment
- Energetic Materials and Combustion
- Fatigue and fracture mechanics
- Insect and Arachnid Ecology and Behavior
- Advanced Memory and Neural Computing
- Protein Structure and Dynamics
- DNA Repair Mechanisms
- Aerodynamics and Acoustics in Jet Flows
- Electrolyte and hormonal disorders
- Soil, Finite Element Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Elasticity and Material Modeling
- Cancer therapeutics and mechanisms
- Advanced Fluorescence Microscopy Techniques
- Indoor and Outdoor Localization Technologies
- Vitamin K Research Studies
- Animal Behavior and Reproduction
Northwestern University
1935-2025
Janelia Research Campus
2018-2024
Howard Hughes Medical Institute
2018-2024
University of Ulster
2021
The University of Texas Southwestern Medical Center
2007-2020
Leiden University
2020
Eötvös Loránd University
2020
École des hautes études en sciences sociales
2020
Center for South Asian Studies
2020
Centre National de la Recherche Scientifique
2020
Abstract Memorization and generalization are complementary cognitive processes that jointly promote adaptive behavior. For example, animals should memorize safe routes to specific water sources generalize from these memories discover environmental features predict new ones. These functions depend on systems consolidation mechanisms construct neocortical memory traces hippocampal precursors, but why only applies a subset of is unclear. Here we introduce neural network formalization reveals an...
Abstract Cognitive maps confer animals with flexible intelligence by representing spatial, temporal and abstract relationships that can be used to shape thought, planning behaviour. have been observed in the hippocampus 1 , but their algorithmic form learning mechanisms remain obscure. Here we large-scale, longitudinal two-photon calcium imaging record activity from thousands of neurons CA1 region while mice learned efficiently collect rewards two subtly different linear tracks virtual...
A proper tensorial logarithmic strain measure and its associated time rate of change is developed using an equivalence between the expressions for isotropic tensor function Sylvester-Lagrange formalism. It shown that specific Cauchy stress T/ρ derivable from a potential with respect to this measure. modified TF be left polar decomposition deformation gradient. Advantages disadvantages formulation are discussed.
To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist more ancient brain regions, how they arise from integrated self-motion, by what pathways locomotion. Here, a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to variety involuntary displacements. They tracked these displacements and,...
ABSTRACT Cognitive maps confer animals with flexible intelligence by representing spatial, temporal, and abstract relationships that can be used to shape thought, planning, behavior. have been observed in the hippocampus, but their algorithmic form processes which they are learned remain obscure. Here, we employed large-scale, longitudinal two-photon calcium imaging record activity from thousands of neurons CA1 region hippocampus while mice efficiently collect rewards two subtly different...
Diffuse panbronchiolitis (DPB), an important cause of progressive obstructive lung disease in the Far East, represents a distinctive sinobronchial syndrome with typical radiologic and histologic features. We have identified DPB five citizens United States, three confirmation, who never traveled to East. There were four men one woman, whose ages ranged from 46 75 yr at time diagnosis. All had prior history chronic sinusitis presented cough, dyspnea, sputum production. Three smokers two...
Gemfibrozil, a novel hypolipidemic agent identified chemically as 2,2-dimethyl-5-(2,5-xylyoxy) valeric acid, was evaluated for mutagenic potential in vitro assays with Salmonella typhimurium. For evaluation of tumorigenic potential, gemfibrozil administered the diet (0.30, and 300 mg gemfibrozil/kg) to groups noninbred CD-1 mice (72/sex) CD rats (50/sex) 78 104 weeks, respectively. In bacterial mutagenesis assays, between 100 2,500 microgram gemfibrozil/plate failed induce significant...
Spontaneous development of tumors in 5086 Holtzman-source rats ranging age from 1 to 18 months is reviewed. Overall incidence was 4.3% (8.2% for females, 2.3% males). Statistical analysis the data demonstrated that potentiality comparable previously reported lifetime studies. Characteristics are given, and more uncommon described briefly. The occurrence young this survey indicates need accumulating on other than “old” as an aid interpreting obtained toxicological
Neural network remodeling underpins the ability to remember life experiences, but little is known about long-term plasticity of neural populations. To study how brain encodes episodic events, we used time-lapse two-photon microscopy and a fluorescent reporter based on an enhanced form synaptic activity-responsive element (E-SARE) within Arc promoter track thousands CA1 hippocampal pyramidal cells over weeks in mice that repeatedly encountered different environments. Each environment evokes...
Many animals use visual signals to estimate motion. Canonical models suppose that motion by cross-correlating pairs of spatiotemporally separated signals, but recent experiments indicate humans and flies perceive from higher-order correlations signify in natural environments. Here we show how biologically plausible processing motifs neural circuits could be tuned extract this information. We emphasize known aspects Drosophila's circuitry embody tuning predict fly behavior. find segregating...
Internal signals from the body and external environment are processed by brain-wide circuits to guide behavior. However, complete circuit activity underlying interoception - perception of bodily its interactions with sensorimotor remain unclear due technical barriers accessing whole-brain at cellular level during organ physiology perturbations. We developed an all-optical system for neuronal imaging in behaving larval zebrafish optical uncaging gut-targeted nutrients visuo-motor stimulation....
Since the demonstration that sequence of a protein encodes its structure, prediction structure from remains an outstanding problem impacts numerous scientific disciplines, including many genome projects. By iteratively fixing secondary assignments residues during Monte Carlo simulations folding, our coarse-grained model without information concerning homology or explicit side chains can outperform current homology-based methods for proteins. The computationally rapid algorithm using only...
ABSTRACT Memorization and generalization are complementary cognitive processes that jointly promote adaptive behavior. For example, animals should memorize a safe route to water source generalize features allow them find new sources, without expecting paths exactly resemble previous ones. Memory aids by allowing the brain extract general patterns from specific instances were spread across time, such as when humans progressively build semantic knowledge episodic memories. This process depends...
Abstract The calcium salt of valproic acid (Valontin) has been proposed for use in the treatment absence, myoclonic, and tonic clonic seizures primarily generalized type. present study was conducted to determine teratogenic potential valproate rabbits. Groups 20 Dutch‐belted rabbits were given oral doses 50, 150, or 350 mg/kg on days 6–18 gestation. A referece group sodium control groups untreated vehicle alone. Animals observed daily body weights recorded gestation 0, 6, 13, 18, 30. Litter...