A5061274889- Neuroscience and Neuropharmacology Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Neural dynamics and brain function
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Computational Fluid Dynamics and Aerodynamics
- Retinal Development and Disorders
- Advanced Fluorescence Microscopy Techniques
- Turbomachinery Performance and Optimization
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Vestibular and auditory disorders
- Advanced Neuroimaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Cardiac Valve Diseases and Treatments
- Combustion and flame dynamics
- Antibiotic Resistance in Bacteria
- Aortic Disease and Treatment Approaches
- Tracheal and airway disorders
Weizmann Institute of Science
2021-2024
Janelia Research Campus
2014-2022
Howard Hughes Medical Institute
2014-2022
Miwa Internal Medicine Clinic
2020-2021
The University of Tokyo
2007-2020
Sapporo Higashi Tokushukai Hospital
2020
Helix (United States)
2016-2019
Meiji University
2019
Seikei University
2017
Kurashiki Central Hospital
2014-2016
Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at high spatial and temporal resolution. However, the utility existing GEVIs has been limited by brightness photostability fluorescent proteins rhodopsins. We engineered a GEVI, called Voltron, that uses bright photostable synthetic dyes instead protein-based fluorophores, thereby extending number neurons imaged simultaneously in vivo factor 10 enabling imaging for significantly longer durations relative to...
The neuronal immediate early gene Arc/Arg-3.1 is widely used as one of the most reliable molecular markers for intense synaptic activity in vivo. However, cis-acting elements responsible such stringent dependence have not been firmly identified. Here we combined luciferase reporter assays cultured cortical neurons and comparative genome mapping to identify critical activity-responsive (SARE) gene. A major SARE was found a unique approximately 100-bp element located at >5 kb upstream...
To execute accurate movements, animals must continuously adapt their behavior to changes in bodies and environments. Animals can learn the relationship between locomotor commands resulting distance moved, then adjust command strength achieve a desired travel distance. It is largely unknown which circuits implement this form of motor learning, or how. Using whole-brain neuronal imaging circuit manipulations larval zebrafish, we discovered that serotonergic dorsal raphe nucleus (DRN) mediates...
CREB is a pivotal mediator of activity-regulated gene transcription that underlies memory formation and allocation. The contribution key cofactor, CREB-regulated coactivator 1 (CRTC1), has, however, remained elusive. Here we show several constitutive kinase pathways an phosphatase, calcineurin, converge to determine the nucleocytoplasmic shuttling CRTC1. This, in turn, triggered activity-dependent association CRTC1 with CREB-dependent regulatory elements found on IEG promoters. Forced...
Influenza A virus subtype H1N1 with the H274Y mutation emerged and spread worldwide. However, clinical effectiveness of neuraminidase inhibitors, oseltamivir zanamivir, has not been adequately reevaluated.Data from 164 patients infection 59 H3N2 during 2008-2009 influenza season 68 2007-2008 who received a inhibitor were analyzed. The duration fever (body temperature 37.5 degrees C) after first dose or zanamivir onset symptoms was calculated patient reports. isolated, its determined by...
Abstract Serotonergic psychedelics are emerging therapeutics for psychiatric disorders, yet their underlying mechanisms of action in the brain remain largely elusive. Here, we developed a wide-field behavioral tracking system larval zebrafish and investigated effects psilocybin, psychedelic serotonin receptor agonist. Machine learning analyses precise body kinematics identified latent states reflecting spontaneous exploration, visually-driven rapid swimming, irregular swim patterns following...
Background. To evaluate the effectiveness of oseltamivir and amantadine for treatment influenza with respect to various clinical factors, a prospective multicenter study season 2002–2003 was done 2163 patients whose condition diagnosed by an antigen-detection test kit. Methods. Oseltamivir administered 803 A (A+Os group) 684 B (B+Os group). Amantadine 676 (A+Am Results. For each group, duration fever (i.e., body temperature, ⩾37.5°C) significantly shorter in who received drug within 12 h...
Neural network remodeling underpins the ability to remember life experiences, but little is known about long-term plasticity of neural populations. To study how brain encodes episodic events, we used time-lapse two-photon microscopy and a fluorescent reporter based on an enhanced form synaptic activity-responsive element (E-SARE) within Arc promoter track thousands CA1 hippocampal pyramidal cells over weeks in mice that repeatedly encountered different environments. Each environment evokes...
In Experiment 1, 3 budgerigars ( Melopsittacus undulatus ) were trained with food reinforcement to make low‐ or high‐frequency calls in response different color stimuli, C1 and C2 (a color‐naming task), using a gradual response‐differentiation procedure an automatic call‐recognition system. Thus, call within certain frequency band was reinforced the presence of (“C1 call”), (“C2 call”). 2, all form‐to‐color matching‐to‐sample task, alternating trial by either task (2 birds) identity (1...
The adiabatic calorimeter used for specific heat measurements was improved the of heats mixing. temperature difference between and blocks is kept to be zero through P.I.D controller, in order that effect which arises block can measured adiabatically. This conveniently applied various kinds thermal data, evaluation data obtained becomes very simple.Heats mixing four liquid binary systems such as lead-bismuth, lead-tin, indium-tin, indium-bismuth, were determined range 300°C 900°C. results...