A5075282308- Multiple Myeloma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Lymphocytic Leukemia Research
- Autoimmune Bullous Skin Diseases
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Malaria Research and Control
- Chronic Myeloid Leukemia Treatments
- Computational Drug Discovery Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ Transplantation Techniques and Outcomes
- Hemoglobinopathies and Related Disorders
- Nutrition, Genetics, and Disease
- Peptidase Inhibition and Analysis
- Medication Adherence and Compliance
- Pharmaceutical studies and practices
- Renal Transplantation Outcomes and Treatments
- Cancer Treatment and Pharmacology
- Chemotherapy-related skin toxicity
- Antibiotic Use and Resistance
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pharmaceutical Practices and Patient Outcomes
University of Liverpool
2023-2025
Pfizer (United States)
2022-2024
Boston Medical Center
2018-2023
Boston University
2018-2023
Amyloidosis Foundation
2021
Novartis (Switzerland)
2019
University of California San Francisco Medical Center
2019
Arrowe Park Hospital
2009-2017
University of Illinois Hospital & Health Sciences System
2014
University of Illinois Chicago
2014
A Phase 1 study of high-dose “pulse” methotrexate infusions combined with citrovorum factor “rescue” in advanced lung cancer indicated consistent tumor response eight patients. dose schedule allowing for repeated treatments, and thus suitable prolonged management, was developed. Three patients treated accordingly 8 to 10 months continue show regression their original lesions without evidence new metastases. These observations are previously proposed concepts use after administration “pulses”...
A clinical trial of the effect vitamin B<sub>12</sub> therapy was conducted in 39 elderly subjects who had been found, a community screening survey, to have low levels serum without macrocytic anaemia or neuropathy. The study produced no evidence which suggests that such is superior placebo effecting an improvement psychiatric state general well-being. There clear tendency for all show during trial, but this probably represents therapeutic involvement research exercise kind.
To estimate the budget impact of adding elranatamab to US formulary treat adults with RRMM who have received ≥4 prior lines therapy including a proteasome inhibitor, an immunomodulatory drug, and anti-CD38 monoclonal antibody, assess total cost care per month progression-free survival (PFS) between available treatments. An economic model was developed in one-million-member commercial Medicare health plan. Epidemiology data obtained from SEER database large real-world study. Key clinical...
Abstract Background The novel anti-malarial cipargamin (KAE609) has potent, rapid activity against Plasmodium falciparum . Transient asymptomatic liver function test elevations were previously observed in cipargamin-treated subjects two trials: one malaria patients Asia and volunteers with experimentally induced malaria. In this study, the hepatic safety of given as single doses 10 to 150 mg 50 once daily for 3 days was assessed. Efficacy results, frequency treatment-emerging mutations atp4...
Abstract Objectives To compare a Bayesian clinical decision support (CDS) dose-optimizing software program with clinician judgement in individualizing vancomycin dosing regimens to achieve pharmacokinetic (PK)/pharmacodynamic (PD) targets paediatric population. Methods A retrospective review combined model-based simulation of was performed on children aged 1 year 18 years at the University California, San Francisco Benioff Children’s Hospital Mission Bay. Dosing recommended by pharmacists,...
Fostamatinib is an oral spleen tyrosine kinase (SYK) inhibitor used for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have had insufficient response to a previous treatment. Clinical and operational barriers may exist that warrant bridging or switching from thrombopoietin receptor agonists (TPO-RAs), such as volatility unpredictability platelets, adverse events, quality life patient preference. While fostamatinib demonstrated durable platelet responses,...
Since the approval of cyclin-dependent kinase 4/6 inhibitors in 2015, this oral cancer (OC) therapy has been combined with endocrine as first-line treatment metastatic hormone receptor-positive breast cancer, adding unique toxicity and complexity to successful administration medication. Implementation OC is challenging because delays nonadherence worse among vulnerable patient populations. Pharmacists may mitigate these barriers facilitation prior authorizations, communication pharmacies,...
<h3>OBJECTIVE</h3> To test the hypothesis that depression in patients being considered for cervical disc surgery is associated with severe organic pathology. Secondly, to whether and abnormal illness attitudes recorded preoperatively would predict poorer recovery. <h3>METHODS</h3> Seventy four pain disability from arthrosis were examined during investigations before potential surgery. The prevalence of psychiatric disorder was assessed using SCAN, attitude scale. <h3>RESULTS</h3> There a...
Introduction Hepatitis B virus (HBV) infection remains a global public health threat, with approximately 257 million people suffering from chronic HBV worldwide in 2015. reactivation is known complication of immunosuppressive therapy HBV. Medications commonly associated include B-cell depleting agents and anthracycline derivatives. There have been very few documented cases chemoradiation inducing among scientific literature. Case report A 44-year-old woman [FIGO] stage IIIB cervical cancer...
Background and purpose: External Beam Radiotherapy (EBRT) followed by Contact X-ray Brachytherapy (CXB) vice versa are viable alternatives to surgery for selected rectal cancer patients who have small tumours (≤3cm). However, the optimal sequence of treatment needs be established. We compared two approaches using Propensity Score (PS) matching inverse probability weighting (IPTW) analyses investigate whether affected patient outcomes.Materials methodsThis retrospective analysis (2008-2019)...
Background: Accurately recognising that a person may be dying is central for improving their experience of care. Yet difficult and predicting frequently inaccurate.Methods: Urine samples from patients (n=112 49, training validation cohorts, respectively)) with lung cancer were analysed using high resolution mass spectrometry. Cox lasso regression was engaged to develop multivariable model the probability survival within last 30 days life. ANOVA volcano plot analysis demonstrated metabolites...