A5088169041- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatological and Skeletal Disorders
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Parathyroid Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Galectins and Cancer Biology
- Pharmacological Effects of Natural Compounds
- Hereditary Neurological Disorders
- Immune Cell Function and Interaction
- Skin Protection and Aging
- Flavonoids in Medical Research
- Ginger and Zingiberaceae research
- Inflammation biomarkers and pathways
- Ginkgo biloba and Cashew Applications
- Adenosine and Purinergic Signaling
- Maternal and fetal healthcare
- Genetic Syndromes and Imprinting
- Cardiac tumors and thrombi
- Macrophage Migration Inhibitory Factor
- Medicinal Plants and Neuroprotection
- Antiplatelet Therapy and Cardiovascular Diseases
Konyang University
2017-2024
Chungnam National University
2016-2017
Korea Institute of Oriental Medicine
2013-2015
Chonnam National University
2011-2012
Pai Chai University
2012
Triggering receptor expressed on myeloid cells 2 (TREM2) is known to be involved in the anti-inflammatory response and osteoclast development. However, role of TREM2 adipogenesis or obesity has not yet been defined. The effect was investigated transgenic (TG) mice a high-fat diet (HFD). To block signaling, neutralizing fusion protein specific for (TREM2-Ig) used. TG were much more obese than wild-type after feeding with an HFD, independent quantity food intake. These HFD-fed manifested...
Fructus mume (F. mume) has been used as a traditional medicine for many years in Asian countries. The present study was designed to determine the effect of 70% ethanol extract F. on white matter and hippocampal damage induced by chronic cerebral hypoperfusion.Permanent bilateral common carotid artery occlusion (BCCAo) performed male Wistar rats induce hypoperfusion. Daily oral administration (200 mg/kg) initiated 21 days after BCCAo continued 42 days. experimental groups this were divided...
Phytochemicals have been known to exhibit potent antioxidant activity. This study examined cytoprotective effects of phytochemicals including quercetin, catechin, caffeic acid, and phytic acid against oxidative damage in SK-Hep-1 cells induced by the non-oxidative metabolism ethanol. Exposure excess ethanol resulted a significant increase cytotoxicity, reactive oxygen species (ROS) production, lipid hydroperoxide (LPO), enzyme Excess also caused reduction mitochondrial membrane potential...
Abstract Background The cardiotonic pill (CP) is a herbal medicine composed of Salvia miltiorrhiza (SM), Panax notoginseng (PN), and Dryobalanops aromatica Gaertner (DAG) that widely used to treat cardiovascular diseases. present experiment was conducted examine the effects CP on white matter hippocampal damage induced by chronic cerebral hypoperfusion. Methods Chronic hypoperfusion in male Wistar rats permanent bilateral common carotid artery occlusion (BCCAo). Daily oral administration...
Vascular calcification plays a role in the pathogenesis of atherosclerosis, diabetes, and chronic kidney disease; however, apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) inorganic phosphate (Pi)-induced vascular smooth muscle cell (VSMC) remains unknown. In this study, we investigated possible APE1/Ref-1 Pi-induced VSMC calcification. We observed that Pi decreased endogenous expression promoter activity VSMCs, adenoviral overexpression inhibited VSMCs an ex vivo organ...
Abstract Problem Dysregulation of extravillous trophoblast (EVT) invasion leads to pregnancy complications, such as pre‐eclampsia, fetal growth restriction, and placenta accreta. The aim this study was explore the role SIRT1 in EVT its underlying mechanism. Method SIRT1‐specific siRNA transfected into Swan 71 cells, an immortalized first trimester cell line. Boyden chamber assay, scratch wound healing proliferation assay were performed. expression levels epithelial‐to‐mesenchymal transition...
Problem Vitamin D deficiency increases the risk of developing pregnancy‐related complications, including preeclampsia and small‐for‐gestational‐age infants. was demonstrated to promote invasiveness human extravillous trophoblasts ( EVT s). However, whether vitamin induces epithelial‐mesenchymal transition EMT ) s remains unclear. Therefore, we investigated promotes related signaling pathways. Method study In this study, performed experiments using JAR cells based on expression mesenchymal...
Background/Aim: The abnormal growth of vascular smooth muscle cells (VSMCs) induced by reactive oxygen species (ROS) is considered a major pathogenic process in diseases. Interleukin (IL)-24 specifically inhibits cancer cell through the induction cycle arrest and apoptosis. However, role IL-24 ROS-induced VSMC has not yet been investigated. Methods: An MTT assay, gene expression analysis, flow cytometry scratch wound healing assay were performed to determine anti-growth effects H2O2-treated...
Enalapril and nifedipine are used as antihypertensive drugs; however, the therapeutic target molecules regulated by enalapril have yet to be fully identified. The aim of this study was identify novel genes that specifically in tissues from spontaneously hypertensive rats (SHR) using DNA microarray analysis. We found administration SHR with differentially 33 involved pathogenesis cardiovascular diseases. Furthermore, we identified 16 not previously been implicated diseases, including...
Objectives: The aim of this study was to examine the antithrombotic effects four herbal ingredients (Mume Fructus, MF; Santali Albi Lignum, SAL; Amomi Tsao-Ko ATF; and AF) modified Jeho-tang (MJHT) in a ferric chloride (FeCl3)-induced carotid arterial thrombosis model. Methods: Thirty minutes prior 35% FeCl3 application, Sprague-Dawley (SD) rats were injected with saline, MF, SAL, ATF or AF (100 mg/kg, intraperitoneal injection), respectively. effect MJHT examined for time occlusion (TTO)...
Salicornia herbacea L. (Chenopodiaceae), an edible salt marsh plant with anti-inflammatory effects, was examined in macrophages and trophoblasts whether it modulates NLRP3 inflammasome activity. Pretreatment delayed treatment of S. extract (SHE) bone marrow-derived (BMDMs) reduced the activity induced by lipopolysaccharide (LPS) adenosine triphosphate stimulation downregulated interleukin (IL)-1β production. SHE also inhibited pyroptotic cell death, adaptor molecule apoptosis-associated...
Ulmus davidiana var. japonica Rehder (UD) has long been used in traditional folk medicine Asia. This study is designed to investigate the antiadhesive activity of ethanol extract UD (UDE) and its underlying mechanisms cultured endothelial cells.The dried root bark was extracted with 80% (v/v) ethanol. The UDE investigated human umbilical vein cells embryonic kidney epithelial 293T (HEK 293T) stably transfected pGL3-vascular cell adhesion molecule (VCAM)-1-luc. Monocyte induced by tumor...
Objectives : The aim of this study was to examine anti-thrombotic effect traditional herbal extracts in a rat model ferric chloride (<TEX>$FeCl_3$</TEX>)-induced carotid arterial thrombosis. Methods Thirty minutes prior 35% <TEX>$FeCl_3$</TEX> application, Sprague Dawley(SD) rats were injected with the 10 types (100mg/kg, intraperitoneal injection), respectively. these examined for time occlusion(TTO) using Laser doppler flow meter and measured thrombus weight (TW)...
Objectives: This study examined the effects of 8 types herbal prescriptions prescribed to alleviate dementia symptoms in a rat model arterial thrombosis induced by ferric chloride (FeCl3). Methods: Thirty minutes before 35% FeCl3 treatment, SD rats were intraperitoneally injected with prescriptions, respectively. We tested on time occlusion (TTO) an using laser Doppler flow meter. In addition, thrombus weight (TW) and collagen fiber damages evaluated same condition. Results: Herbal showed...
Objective: Ulmus davidiana var. japonica Rehder (UD) has long been used for anticancer and anti-inflammatory therapy as in traditional Korean medicine. This study was designed to investigate the effect of UD on tumor necrosis factor-α (TNF-α)-induced monocyte adhesion endothelial cells its underlying mechanism. Design Method: The anti-adhesive activities UDE monocyte-endothelial cell adhesion, vascular molecule (VCAM)-1 expression, reactive oxygen species (ROS) production, nuclear factor...
Objective: Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein. Although TSPO expression up-regulated during inflammation, the role of on vascular endothelial cell activation remains to be elucidated. Design and method: In present study, phorbol 12-myristate 13-acetate (PMA), an activator kinase C (PKC), was used induce activation. Results: Adenoviral overexpression inhibited PMA-induced adhesion molecule-1 (VCAM-1) intracellular (ICAM-1) in dose dependent manner....
Abstract Vascular calcification is a hallmark of cardiovascular diseases. The IL-10 family cytokines has been known to suppress the tumor progression in variety human cancers, but its role not yet investigated vascular calcification. To determine whether can inhibit calcification, effect on was examined β-glycerophosphate (β-GP)-induced smooth muscle cells (VSMCs) model. Calcium deposition declined cytokines-treated calcified VSMCs. expression Runx2 and alkaline phosphatase also suppressed...
Abstract HeLa cervical cancer cells stably overexpressing human papilomavirus (HPV)16 E6, HE6F cells, were established to investigate the growth inhibitory effect by interleukin-24 (IL-24). The expression of angiogenesis-associated genes was upregulated in compared that mock-transfection control which led suppression apoptosis and consequent augmentation their growth. However, when treated with recombinant IL-24 (rhIL-24), inhibited downregulation gene induction apoptosis. In our previous...