A5101531765- Mycobacterium research and diagnosis
- Reproductive System and Pregnancy
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Tuberculosis Research and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Viral Infectious Diseases and Gene Expression in Insects
- Autophagy in Disease and Therapy
- Meteorological Phenomena and Simulations
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- Tropical and Extratropical Cyclones Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Endometriosis Research and Treatment
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- RNA Research and Splicing
- Preterm Birth and Chorioamnionitis
- Cholesterol and Lipid Metabolism
- Allergic Rhinitis and Sensitization
- Cancer Mechanisms and Therapy
- Genetic factors in colorectal cancer
Konyang University
2018-2025
Konyang University Hospital
2025
Dalhousie University
2023
Gilead Sciences (United States)
2023
Eli Lilly (United States)
2017
Yonsei University
2013-2015
Kyungpook National University
2014
Chungnam National University
2012
Alzheimer's disease (AD) is the most common neurodegenerative and characterized by neurodegeneration cognitive deficits. Amyloid beta (Aβ) peptide known to be a major cause of AD pathogenesis. However, recent studies have clarified that mitochondrial deficiency also mediator or trigger for development. Interestingly, red ginseng (RG) has been demonstrated beneficial effects on pathology. there no evidence showing whether RG extract (RGE) can inhibit deficit-mediated pathology in experimental...
Mycobacterium abscessus (Mab), a nontuberculous mycobacterium, is increasing in prevalence worldwide and causes treatment-refractory pulmonary diseases. However, how Mab rewires macrophage energy metabolism to facilitate its survival poorly understood. We compared the metabolic profiles of murine bone marrow-derived macrophages (BMDMs) infected with smooth (S)- rough (R)-type using extracellular flux technology. infection shifted BMDMs towards more energetic phenotype, marked by increased...
It has been reported that damage to the mitochondria affects progression of Alzheimer’s disease (AD), and mitochondrial dysfunction is improved by omega-3. However, no animal or cell model studies have confirmed whether omega-3 inhibits AD pathology related deficits. In this study, we aimed (1) identify mitigating effects endogenous on deficits induced amyloid beta (Aβ) in fat-1 mice, a transgenic polyunsaturated fatty acids (PUFAs)-producing animal; (2) if docosahexaenoic acid (DHA)...
Pathological maternal inflammation and abnormal placentation contribute to several pregnancy-related disorders, including preterm birth, intrauterine growth restriction, preeclampsia. TANK-binding kinase 1 (TBK1), a serine/threonine kinase, has been implicated in the regulation of various physiological processes, innate immune response, autophagy, cell growth. However, relevance TBK1 placental pro-inflammatory environment not investigated. In this study, we assessed effect inhibition on...
Background: Currently, obesity is a global health challenge due to its increasing prevalence and associated risk. It with various metabolic diseases, including diabetes, hypertension, cardiovascular disease, stroke, certain forms of cancer, non-alcoholic liver diseases (NAFLD). Objective: The aim this study evaluate the effects polyphenol enriched herbal complex (Rubus crataegifolius/ellagic acid, Crataegus pinnatifida Bunge/vitexin, chlorogenic Cinnamomum cassiaa/cinnamic acid) on induced...
Ulcerative colitis is a complex inflammatory bowel disorder disease that can induce rectal and colonic dysfunction. Although the prevalence of IBD in Western countries almost 0.5% general population, genetic causes are still not fully understood. In recent discovery, itaconate was found to function as an immune-modulating metabolite mammalian immune cells, wherein it synthesized antimicrobial compound from citric acid cycle intermediate cis-aconitic acid. However, association between Acod1...
Oncogenic activation of the mammalian target rapamycin complex 1 (mTORC1) leads to endometrial cancer cell growth and proliferation. Sestrin2 (SESN2), a highly conserved stress-inducible protein, is involved in homeostatic regulation via inhibition reactive oxygen species (ROS) mTORC1. However, role SESN2 human remains be investigated. Here, we investigated expression, clinical significance, underlying mechanisms cancer. was upregulated more tissues than normal tissues. Furthermore,...
Obesity, a serious threat to public health, is linked chronic metabolic complications including insulin resistance, type-2 diabetes, and dysfunction-associated fatty liver disease (MAFLD). Current obesity medications are challenged by poor effectiveness, patient compliance, potential side effects. Verapamil an inhibitor of L-type calcium channels, FDA-approved for the treatment hypertension. We previously investigated effect verapamil on modulating autophagy treat obesity-associated...
Neuron damage by microglia, which act as macrophage cells in the brain, can result various brain diseases. However, function of pro-inflammatory or anti-inflammatory microglia neurons remains controversial. Guanylate-binding protein-2 (GBP2) is expressed and activated early phase inflammatory response plays an important role controlling immune responses. In this study, we evaluated whether GBP2 initially reduces induced induce functions via expression. lipopolysaccharide (LPS)-stimulated...
Endometriosis is a chronic gynecological disorder, characterized by the presence of ectopic endometrial tissue outside uterine cavity. Among several hypotheses, Sampson's theory retrograde menstruation still applicable. Recent studies have reported importance inflammation among tissue, peritoneum, and immune cells. However, less known regarding role bacterial infection in pathophysiology endometriosis. We hypothesized that U. urealyticum might contribute to development endometriosis inducing...
Although the incidence of Mycobacterium abscessus infection has recently increased significantly, treatment is difficult because this bacterium resistant to most anti-tuberculosis drugs. In particular, M. often available macrolide antibiotics, so therapeutic options are extremely limited. Hence, there a pressing demand create effective drugs or regimens for infections. The aim investigation was assess capability isoegomaketone (iEMK) as option treating We determined minimum inhibitory...
Introduction: Metabolism-associated fatty liver disease (MAFLD) is a global health concern because of its association with obesity, insulin resistance, and other metabolic abnormalities. Methylsulfonylmethane (MSM), an organic sulfur compound found in various plants animals, exerts antioxidant anti-inflammatory effects. Here, we aimed to assess the anti-obesity activity autophagy-related mechanisms Methylsulfonylmethane. Method: Human hepatoma (HepG2) cells treated palmitic acid (PA) were...
Mycobacterium tuberculosis was responsible for 1.3 million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against (TB); however, it has limited protective efficacy adults. In this study, we constructed a recombinant vaccinia virus expressing Ag85B from M. using novel attenuated (KVAC103). We then analyzed immunogenicity of prime-boost inoculation strategies KVAC103 (rKVAC85B) compared to BCG. both rKVAC85B and BCG prime-rKVAC85B boost regimens, induced...
Breast cancer in women is one of the most common life-threatening malignancies. Despite development for improved treatment, there are still many limitations to overcome. Among them, stem cells (CSCs) well known tumor formation, development, cellular heterogeneity, and recurrence. Therefore, completely cure breast cancer, treatment both CSC required. To selectively target CSCs, we generated a liposome-based smart nano complex using CEACAM 6 (CD66c) antibody (Ab), novel cell-surface biomarker...
Tobacco smoking (TS) has been known as one of the most potent risk factors for airway inflammatory diseases. However, there a paucity information regarding immunologic alteration mediated by TS in patients with chronic rhinosinusitis nasal polyps (CRSwNP). To identify effect TS, we harvested human tissue samples (never smoker: n=41, current n=22, quitter: n=23) and analyzed expression epithelial-derived cytokines (EDCs) such IL-25, IL-33, thymic stromal lymphopoietin. The expressions Th2...
Although skeletal muscle is a specialized tissue that provides the motor for movement, it also participates in other functions, including immune response. However, little known about effects of this multitasking on muscle. We show loses some its capacity while participating Caterpillars (Manduca sexta) were exposed to an challenge, predator stress or combination challenge and stress. The expression genes (toll-1, domeless, cactus, tube attacin) increased body wall after exposure challenge....
Highly luminescent europium complexes modified mesoporous silica particles (MSP) were synthesized as an imaging probes for both in-vitro diagnostic and in-vivo cellular tracking agents. Europium β-diketone chelates (4,4,4-trifluoro-l-(2-thienyl)-l,3-butanedione) trioctylphosphine (III) (Eu(TTA)3(P(Oct)3)3) incorporated inside the nanocavities that existed in hierarchical MSP (Eu@MSP). The Eu@MSP on mouse bone marrow-derived macrophages (BMDMs) did not show any toxic effect. BMDMs found at...
Hyperammonemia associated with overt hepatic encephalopathy (OHE) causes excitotoxic neuronal death through activation of the cytochrome C (CytC)-mediated mitochondria-dependent apoptotic pathway. We tested therapeutic effect nortriptyline (NT), a mitochondrial permeability transition pore (mPTP) blocker that can possibly inhibit CytC efflux to cytosol on in vivo and vitro OHE models. After ensuring generation rats, established by bile duct ligation (BDL), they were intraperitoneally...
Mycobacterium mucogenicum (Mmuc), a rapidly growing nontuberculous mycobacterium (NTM), can infect humans (posttraumatic wound infections and catheter-related sepsis). Similar to other NTM species, Mmuc exhibits colony morphologies of rough (Mmuc-R) smooth (Mmuc-S) types. Although there are several case reports on infection, no experimental evidence supports that the R-type is more virulent. In addition, immune response metabolic reprogramming have not been studied basis morphological...