A5102795742- Food Quality and Safety Studies
- Microbial Metabolism and Applications
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Seaweed-derived Bioactive Compounds
- Consumer Perception and Purchasing Behavior
- Forensic Toxicology and Drug Analysis
- Gout, Hyperuricemia, Uric Acid
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Bioactive Compounds
- Ion Channels and Receptors
- Cannabis and Cannabinoid Research
- Cancer-related Molecular Pathways
- Pain Mechanisms and Treatments
- Tea Polyphenols and Effects
- Ginseng Biological Effects and Applications
- Alcohol Consumption and Health Effects
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Bioactive Compounds and Antitumor Agents
Dong-Eui University
2022
Hanmi Pharmaceutical (South Korea)
2019-2021
Sungkyunkwan University
2012-2020
Seoul National University
2020
Konyang University
2019
Sungshin Women's University
2014-2018
Inje University
2013
Pusan National University
2009-2010
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms human depression.In present study, we used a chronic animal model depression and anxiety examine responses two strains have different behavioral responsiveness.An outbred ICR inbred C57BL/6 strain were selected because they are widely tests.The results showed similarly responsive CMS treatment sucrose intake test (SIT) open field (OFT).However, quite forced swimming (FST)...
Alzheimer's disease (AD) is the most common neurodegenerative and characterized by neurodegeneration cognitive deficits. Amyloid beta (Aβ) peptide known to be a major cause of AD pathogenesis. However, recent studies have clarified that mitochondrial deficiency also mediator or trigger for development. Interestingly, red ginseng (RG) has been demonstrated beneficial effects on pathology. there no evidence showing whether RG extract (RGE) can inhibit deficit-mediated pathology in experimental...
Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because produces euphoric and hallucinogenic effects, they been distributed illegally under street names "Spice" "Smoke". Many countries including Korea started to schedule some of compounds controlled substances, but there are a number chemicals that remain uncontrolled by law. In this study, three synthetic CBs with different binding affinities CB1 receptor (JWH-073, 081, 210)...
Four Korean kernel fruit (apple, pear, persimmon, and mandarin orange) juices were obtained by household processing techniques (i.e., blending, juicing). Whole flesh fractions of each extracted a blender or juicer then examined for phytochemical content organic acids, polyphenol compounds). The antioxidant capacity juice was determined ferric reducing power (FRAP) 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. Results revealed that had been prepared blending whole fruits stronger activities...
Skin is an important barrier to protect the body from environmental stress. However, exposure ultraviolet radiation (UV) and various oxidative stresses can cause skin inflammation. Cyclooxygenase-2 (COX-2) inducible enzyme that mediates formation of prostaglandin E2 (PGE2) against internal external inflammatory stimulations. Therefore, inhibition COX-2 approach maintain health prevent inflammation carcinogenesis. Topsentin, a bis(indolyl)imidazole alkaloid isolated marine sponge...
본 연구에서는 조릿대잎 추출물의 탄수화물 소화효소의 저해와 혈당강하효과를 조사하기 위해, 소화효소인 α-glucosidase와 α-amylase의 저해활성과 STZ 유발 당뇨생쥐를 이용한 측정하였다. 메탄올 추출물은 0.5 ㎎/mL 농도에서 yeast α-glucosidase 활성을 18.61% 저해하였으며, ethylacetate층은 48.46%, buthanol층은 41.91%의 저해활성을 나타내어 40.31%의 보인 acarbose보다 저해효과가 높은 것으로 나타냈다. 또한 0.5㎎/mL α-amylase 22.16% 56.31%, 43.66%의 41.14%를 나타낸 따라서 추출물 중 ethylacetate층과 저해활성에서 제2형 당뇨병환자의 혈당 강하제로 처방되고 있는 저해능을 가진 나타났다. STZ으로 당뇨를 유발한 생쥐와 정상생쥐에게 시료의 수율 및 저해활성이 buthanol층을 전분과 함께 경구 투여한 후 증가를 측정한 결과, 조릿대 잎 경우가 전분만 경우에 비해...
Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix.It frequently used as tranditional oriental medicine herbal treatment for swelling and injury detoxification.However, the effects of LQ on cognitive function have not been fully explored.In this study, we evaluated memory-enhancing underlying mechanisms with focus N-methyl-D-aspartic acid receptor (NMDAR) in mice.Learning memory ability were Y-maze passive avoidance tests following administration LQ.In addition,...
We investigated the potential hypouricemic and antioxidant activities of soy vinegar brewed from soybeans fermented with Monascus pilosus KCCM 60084 in potassium oxonate-induced hyperuricemic mice. Soy extracts (SVEs), which contain free isoflavones, ubiquinones, γ-aminobutyric acid, gallic acetic reduced level uric acid (UA) by decreasing UA production through xanthine oxidase inhibition increasing excretion uricase activity mice (P < .05). Moreover, SVE administration increased hepatic...
현미와 홍국발효 콩 시료의 첨가량을 달리하여 제조한 식초의 미용건강기능성 소재(cosmeceuticals)로의 활용 가능성을 평가한 결과는 다음과 같다. DPPH와 ABTS 라디칼 소거능으로 측정한 항산화 활성은 현미 식초에 비해 홍국발효콩이 첨가된 시료가 첨가량에 비례하여 최대 7배 이상 증가하였다(P0.05). 특히 tyrosinase 저해 50% 첨가량의 시료에서 kojic acid의 활성과 유사하게 나타나 미백 소재로서의 보였으며, elastase 활성 역시 유의적으로 현미식초에 콩을 1:1(w/w)의 비율로 첨가한 높은 생리활성은 시료에 함유된 총 페놀 함량, 이소플라본 비배당체형의 genistein과 daidzein의 농도와 상관관계가 성립되었다.
The present study was carried out to investigate the effect of 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-one (bispidinone) analogs on in vitro growth human cervical carcinoma (HeLa) cells. A series 11 bispidinone synthesized with substituents, e.g., fluoro/methyl/ethyl/isopropyl/thiomethyl/methoxy groups, at various positions. These compounds were identify which substituent and position induced strongest cytotoxic cancer Among these synthetics, analog 9, contains methoxy had most...
Centella asiatica (L.) Urban (C. asiatica) is a traditional herbal medicine that has been used for wound healing and anti-inflammation since ancient times. Various biological effects of C. ethanolic extract (CAE) were previously reported. However, in our previous study, aqueous (CAA) exhibited higher inhibitory activity on benign prostatic hyperplasia (BPH) than CAE. Therefore, the aim this study was to investigate effect CAA BPH, elucidate mechanism through vitro vivo experiments as well...
In recent years, there have been frequent reports on the adverse effects of synthetic cannabinoid (SC) abuse. SCs cause psychoactive effects, similar to those caused by marijuana, binding and activating receptor 1 (CB1R) in central nervous system. The aim this study was establish a reliable quantitative structure–activity relationship (QSAR) model correlate structures physicochemical properties various with their CB1R-binding affinities. We prepared tetrahydrocannabinol (THC) 14 derivatives...
시판 과일 주스와 발효식초의 총 페놀 함량, 플라보노이드함량, 유기산 그리고 xanthine oxidase(XO) 저해 활성을 비교하였다. 식초에 함유된 페놀(mg gallic acid equivalent/100 mL)과 플라보노이드(mg catechin mL) 함량은 각각 82.8~157.6 mg과 15.7~85.8 mg으로 측정되었다. 주스류에서는 사과 주스, 식초류에서는 흑초가 가장 높은 함량과 플라보노이드를 함유하였다. 유기산의 함량 중 citric acid, malic ascorbic acid는 주로 주스에서 검출되었다. Acetic acid가 주성분인(688.3~4,413.7 mg/100 식초류 중에서 흑초는 acetic acid뿐 아니라 tartaric acid를 함유하여 분포가 다양하였다. XO 활성은 주스보다 식초가 평균 34.2% 더 높게 측정되었으며, 64.9%로 나타내었다. 특히 종류 아세트산의 활성 간에 정의 상관성이 존재하여(R²=0.7192)...
Abstract Either enhancer of zeste homolog 2 (EZH2) or its EZH1, the enzymatic core subunit polycomb repressive complex (PRC2), acts an essential role for maintenance transcriptional repression by methylation histone H3 lysine 27 (H3K27). EZH2 gain-of-function (GOF) mutations (e.g. Y641, A677, and A687) wild-type activation cause increased activity leading to hyperinduce trimethylation H3K27 (H3K27me3). Meanwhile, loss-of-function (LOF) mutation major components ARID1A, PBRM1, INI1) in...
This study was designed to investigate the protective effect of Sasa borealis leaf extract on 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress in LLC-PK1 cells (porcine kidney epithelial cells). The butanol fraction from (SBBF) used this because it possessed strong antioxidant activity and high yield among fractions. Exposure 1 mM AAPH for 24 hr resulted a significant decrease cell viability, but SBBF treatment protected AAPH-induced damage dose dependant manner....
홍국발효 콩을 소재로 기능성 식초를 제조하기 위해 초산발효 동안(30°C, 28일) pH와 적정산도 및 기질에 함유된 생리활성 물질의 변화를 평가하였다. 기질의 총 적정산도(%)와 pH는 발효 20일 이후에 각각 5.87%와 pH 3.1로 나타나 일반 식초류의 산도 범위와 유사하였다. 주요 유기산은 acetic acid와 lactic acid로 전보다 5.9배(55.94±1.57 ㎎/mL)와 5.4배(3.89±0.08 ㎎/mL) 증가하였다(P<0.05). 폴리페놀과 플라보노이드 함량 역시 초산발효가 진행됨에 따라 최대로 1.9배와 2.2배 높게 측정되었다. 콩 식초에 이소플라본은 비배당체형의 daidzein, glycitein, genistein으로 확인되었으며, 초산발효에 따른 농도의 유의적인 차이는 나타나지 않았다(P0.05). 식초의 유비퀴논(CoQ₉+CoQSUB10/SUB) 함량에 미치는 초산발효의 영향은 CoQSUB10/SUB에 비해 CoQ₉의 증가를 유도하여 최대...
In the present study, a biologically active 4-(trifluoromethyl)phenyl piperazin moiety was linked to 2,2- dimethyl -2H-benzopyran template generate (3R,4S)-2,2-dimethyl-6-nitro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl) chroman -3-ol (C110g), and cellular molecular mechanisms by which C110g exerts cytotoxic effects on HeLa human cervical cancer cell line were further investigated. suppressed viability of cells in both concentration- time-dependent manner (IC50 17 µM) inducing DNA damage...