A5035099099- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Forensic Toxicology and Drug Analysis
- Neuropeptides and Animal Physiology
- Parkinson's Disease Mechanisms and Treatments
- Pharmacology and Obesity Treatment
- Sleep and Wakefulness Research
- Medicinal Plant Extracts Effects
- Stress Responses and Cortisol
- Ziziphus Jujuba Studies and Applications
- Phytochemistry and Biological Activities
- Biological and pharmacological studies of plants
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
Mayo Clinic
2019-2023
WinnMed
2018-2023
Korea Advanced Institute of Science and Technology
2021
Institute of Biomedical Sciences, Academia Sinica
2019
Sungkyunkwan University
2010-2019
Mayo Clinic in Florida
2019
Abstract The external globus pallidus (GPe) coordinates action-selection through GABAergic projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively to dorsal striatum, which regulates goal-directed and habitual seeking. However, role of arky in reward-seeking remains unknown. Here, we identified that a majority target dorsolateral striatum (DLS). Using fiber photometry, found activities were higher during random interval (RI; habit) compared ratio (RR;...
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms human depression.In present study, we used a chronic animal model depression and anxiety examine responses two strains have different behavioral responsiveness.An outbred ICR inbred C57BL/6 strain were selected because they are widely tests.The results showed similarly responsive CMS treatment sucrose intake test (SIT) open field (OFT).However, quite forced swimming (FST)...
Adenosine 2A receptor (A<sub>2A</sub>R)-containing indirect medium spiny neurons (iMSNs) in the dorsomedial striatum (DMS) contribute to reward-seeking behaviors. However, those roles for ethanol-seeking behaviors remain unknown. To investigate behaviors, we used an ethanol-containing reward (10% ethanol and 10% sucrose solution; 10E10S). Upon conditioning with 10E10S, mice that initially only preferred sucrose, not showed a stronger preference 10E10S. Then, investigated whether manipulation...
In the current study, we evaluated anti-inflammatory effects of Lonicera japonica THUNB. (LJ) and its underlying molecular mechanism in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Our results indicated that LJ significantly inhibits LPS-stimulated production nitric oxide (NO) prostaglandin E2 (PGE2). addition, inhibited inducible synthase (iNOS) cyclooxygenase-2 (COX-2) at both protein mRNA levels. cells, proinflammatory cytokines chemokines, tumor necrosis factor-α (TNF-α),...
Alcohol use disorder (AUD) is characterized as chronic, relapsing disease evolving a pattern of excessive drinking despite the negative consequences to an individual's life. Severe chronic alcohol impairs function medial prefrontal cortex (mPFC), which attributed alcohol-induced cognitive and executive dysfunction. However, how deteriorates brain mitochondria, especially in mPFC, critically involved function, has not been clearly understood. Here, we identified morphological functional...
An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-making–related disorders, including addiction. Although external globus pallidus (GPe) critical for action selection, which harbors enriched astrocytes, the role GPe astrocytes involved action-selection strategies remained unknown. Using vivo calcium signaling with fiber photometry, we found substantially attenuated astrocytic activity during learning compared to learning. The support vector machine...
Tramadol is an opioid analgesic agent that has been the subject of a series case reports suggesting potential for misuse or abuse.However, it not controlled substance and generally considered addictive in Korea.In this study, we examined dependence abuse liability tramadol as well its effect on dopaminergic serotonergic systems rodents.In animal behavioral tests, did show any positive effects experimental animals climbing, jumping, head twitch tests.However, conditioned place preference...
Transient receptor potential vanilloid type 1 (TRPV1), the archetypal member of TRP family, was initially identified as for capsaicin, pungent ingredient in hot chili peppers. We previously demonstrated that TRPV1 dorsal striatum significantly contributes to morphine reward by using conditioned place preference paradigm mice; however, it is unknown whether has same effect other models. In this study, we investigated role a self-administration rats. found treatment with selective antagonist,...
Waiting impulsivity is a risk factor for many psychiatric disorders including alcohol use disorder (AUD). Highly impulsive individuals are vulnerable to abuse. However, it not well understood whether chronic increases the propensity behavior. Here, we establish novel experimental paradigm demonstrating that continuous binge-like ethanol exposure progressively leads maladaptive To test waiting impulsivity, employed 5-choice serial reaction time task (5-CSRTT) in C57BL/6J male mice. We...
Abstract Cathinone derivatives are new recreational drugs known to produce psychostimulant effects. However, unlike other psychostimulants, the addictive potential of cathinone has not been widely studied. Here, we investigated effects pentedrone, a type derivative, on dopaminergic system using reverse transcription polymerase chain reaction and Western blot. We also evaluated pentedrone conditioned place preference self‐administration. found that increased mRNA expression dopamine 1...
Substituted cathinones are synthetic analogs of the active components natural products and widely abused worldwide. However, rewarding properties these agents have not yet been evaluated. In this study, we investigated abuse potential buphedrone [2-(methylamino)-1-phenylbutan-1-one, α-methylamino-butyrophenone] its effects on mesolimbic dopaminergic system in mice using conditioned place preference (CPP) analysis, a self-administration test, locomotor activity behavioral sensitization test...
Parkinson's disease (PD) is a severe neurodegenerative characterized by classic motor features associated with the loss of dopaminergic neurons and appearance Lewy bodies in substantia nigra. Due to complexity PD, definitive diagnosis early stages effective management symptoms later are difficult achieve clinical practice. Previous research has shown that colocalization A2A receptors (A2AR) dopamine D2 (D2R) may induce an antagonistic interaction between adenosine dopamine. Clinical trials...