A5047899183- Cancer-related cognitive impairment studies
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Glioma Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Brain Metastases and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Mitochondrial Function and Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenesis and neuroplasticity mechanisms
- Endoplasmic Reticulum Stress and Disease
- Neurosurgical Procedures and Complications
Johnson University
2022-2023
Mayo Clinic
2013-2023
Rutgers, The State University of New Jersey
2022-2023
WinnMed
2008-2023
Mayo Clinic in Arizona
2013-2021
Neurological Surgery
2019
Mayo Clinic in Florida
2006-2013
Jacksonville College
2008-2013
Banner Alzheimer’s Institute
2006
University of Pittsburgh
2006
Adenosine signaling has been implicated in the pathophysiology of many psychiatric disorders including alcoholism. Striatal adenosine A 2A receptors (A R) play an essential role both ethanol drinking and shift from goal-directed action to habitual behavior. However, direct evidence for a striatal R habit development not established. In present study, we found that decreased R-mediated CREB activity dorsomedial striatum (DMS) enhanced initial behavioral acquisition behaviors vulnerability...
Synapses are sites of high energy demand which dependent on levels mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures key for maintenance functional neurotransmission and this critical biological process is modulated by metabolism, distribution, trafficking, cellular calcium flux. Synapse loss presumed to be an early yet progressive pathological event in Alzheimer disease (AD), resulting impaired cognitive function memory particularly prevalent at later...
Abstract Chemotherapy-induced cognitive impairment (CICI) is often reported as a neurotoxic side effect of chemotherapy. Although CICI has emerged significant medical problem, meaningful treatments are not currently available due to lack mechanistic understanding underlying pathophysiology. Using the platinum-based chemotherapy cisplatin model for CICI, we show here that suppresses nicotinamide adenine dinucleotide (NAD+) levels in adult female mouse brain vivo and human cortical neurons...
Chemotherapy-induced cognitive impairment (CICI) has emerged as a significant medical problem without therapeutic options. Using the platinum-based chemotherapy cisplatin to model CICI, we revealed robust elevations in adenosine A 2A receptor (A R) and its downstream effectors, cAMP CREB, by adult mouse hippocampus, critical brain structure for learning memory. Notably, R inhibition Food Drug Administration–approved antagonist KW-6002 prevented cisplatin-induced impairments neural progenitor...
Due to the putative involvement of dopaminergic circuits in depression, triple reuptake inhibitors are being developed as a new class antidepressant, which is hypothesized produce more rapid onset and better efficacy than current antidepressants selective for serotonin or norepinephrine neurotransmission. (<i>1S,2S</i>)-3-(Methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS), inhibitor, potently bound human serotonin, norepinephrine, dopamine transporters with...
The molecular mechanisms underlying the neuronal signaling changes in alcohol addiction and withdrawal are complex multifaceted. cortico-striatal circuit is highly implicated these processes, striatum plays a significant role not only early stages of addiction, but developed-addictive state as well, including symptoms. Transcriptional analysis useful method for determining gene expression, however, results do always accurately correlate with protein levels. In this study, we employ...
Background Mitochondrial short and long-range movements are necessary to generate the energy needed for synaptic signaling plasticity. Therefore, an effective mechanism transport anchor mitochondria pre- post-synaptic terminals is as important functional in neuronal firing. movement range regulated by phosphorylation of cytoskeletal motor proteins addition changes mitochondrial membrane potential. Movement direction serotonin dopamine levels. However, data on defects their involvement...
Abstract Dampened adenosine A 2A receptor (A R) function has been implicated in addiction through enhancement of goal-directed behaviors. However, the contribution R to control impulsive reward seeking remains unknown. Using mice that were exposed differential low rate (DRL) schedules during Pavlovian-conditioning, second-order schedule discrimination, and 5-choice serial reaction time task (5-CSRTT), we demonstrate deficits promote responses. Antagonism lowered ERK1 ERK2 phosphorylation...
Waiting impulsivity is a risk factor for many psychiatric disorders including alcohol use disorder (AUD). Highly impulsive individuals are vulnerable to abuse. However, it not well understood whether chronic increases the propensity behavior. Here, we establish novel experimental paradigm demonstrating that continuous binge-like ethanol exposure progressively leads maladaptive To test waiting impulsivity, employed 5-choice serial reaction time task (5-CSRTT) in C57BL/6J male mice. We...
Abstract The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well levels, are reduced in post-mortem prefrontal cortex subjects. Here, we investigate functional behavior neurotransmission related immune activation psychosis using mice lacking Grk3 utilizing a variety methods, including behavioral, biochemical, electrophysiological, molecular, imaging methods. Compared wildtype...
Chemotherapy-induced cognitive impairment (CICI) is a neurotoxic side effect of chemotherapy that has yet to have an effective treatment.
Wnt signaling is a well-known molecular pathway in age-related pathogenesis and therapy of disease. While prior studies have mainly focused on ligands or activators, the vivo functions naturally secreted inhibitors are not clear, especially brain aging. Using BubR1H/H mice as novel mouse model accelerated aging, we report that genetic inhibition sFRP3 restores reduced body size observed mice. Furthermore, ameliorates hypomyelination corpus callosum rescues neural progenitor proliferation...