A5043655907- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Olfactory and Sensory Function Studies
- Tryptophan and brain disorders
- Peroxisome Proliferator-Activated Receptors
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Radiopharmaceutical Chemistry and Applications
- Drug Transport and Resistance Mechanisms
- Advanced Chemical Sensor Technologies
- Neuroendocrine regulation and behavior
- Cholinesterase and Neurodegenerative Diseases
- Trace Elements in Health
- RNA Interference and Gene Delivery
- Glycogen Storage Diseases and Myoclonus
- Health Systems, Economic Evaluations, Quality of Life
- Click Chemistry and Applications
- Fatty Acid Research and Health
- Stress Responses and Cortisol
- Molecular Sensors and Ion Detection
- Heavy Metal Exposure and Toxicity
- Phytoestrogen effects and research
- Biochemical Analysis and Sensing Techniques
Soonchunhyang University
2025
Mayo Clinic
2022-2024
Gachon University
2018-2023
Mayo Clinic in Arizona
2023
WinnMed
2021-2023
University of California, Irvine
2023
Johns Hopkins University
2023
Institute for Behavioral Medicine
2023
Johns Hopkins Medicine
2023
Korea Advanced Institute of Science and Technology
2021-2022
Abstract Alzheimer’s disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation neurofibrillary tangles (NFTs). While recent 5xFAD AD mouse model exhibits many AD-related phenotypes a relatively early aggressive β production, it does not show NFTs. Here, we developed evaluated novel (6xTg-AD, 6xTg) crossbreeding mice with expressing mutant (P301L) tau protein (MAPT). Through behavioral histopathological tests, analyzed cognitive...
Behavioral flexibility allows animals to adjust actions changing environments. While the basal ganglia are critical for adaptation, specific role of external globus pallidus (GPe) is unclear. This study examined contributions two major GPe cell types-prototypic neurons projecting subthalamic nucleus (Proto GPe→STN neurons) and astrocytes-to behavioral flexibility. Using longitudinal operant conditioning with context reversals, we found that Proto dynamically represent contextual information...
Abstract To investigate the effects of moderate ethanol exposure on glucose metabolism in APP/PS1 mice, an early-onset Alzheimer’s disease (AD) mouse model, we employed fluoro-deoxy-glucose (FDG)-micro-positron emission tomography (PET). We also utilized comprehensive lab animal monitoring system (CLAMS) to measure whole-body energy expenditure and respiratory exchange ratio (RER). found that increased brain as measured by FDG-PET. Also, CLAMS data indicated a decrease RER, suggesting shift...
Chronic alcohol consumption leads to excessive production of reactive oxygen species (ROS), driving oxidative stress that contributes both use disorder (AUD) and Alzheimer’s disease (AD). This review explores how ROS-mediated mitochondrial dysfunction neuroinflammation serve as shared pathological mechanisms linking these conditions. We highlight the role alcohol-induced damage in exacerbating neurodegeneration compare ROS-related pathways AUD AD. Finally, we discuss emerging therapeutic...
The external globus pallidus (GPe) is a central part of the basal ganglia indirect pathway implicated in movement and decision-making. As hub connecting dorsal striatum subthalamic nucleus (STN), GPe guides repetitive routine behaviors. However, it remains unknown how diverse cells engage formation while learning action sequences reward-seeking conditioning. Here, male mice, we investigated Ca 2+ dynamics two cell types, astrocytes parvalbumin-expressing neurons, during formation. Our...
Polygala tenuifolia Willdenow is a herb known for its therapeutic effects in insomnia, depression, disorientation, and memory impairment. In Alzheimer's disease (AD) animal model, there has been no report on the of cognitive PSM-04, an extract from root P. Willdenow, was developed with improved bioabsorption. The present study aimed to investigate neuroprotective PSM-04 AD reveal possible molecular mechanism. effect primary cortical neurons treated L-glutamate, oligomeric Aβ, or H2O2....
Alcohol use disorder has been associated with the development of neurodegenerative diseases, including Alzheimer's disease (AD). However, recent studies demonstrate that moderate alcohol consumption may be protective against dementia and cognitive decline. We examined astrocyte function, low-density lipoprotein (LDL) receptor-related protein 1 (LRP1), NF-κB p65 IKK-α/β signaling pathways in modulating neuroinflammation amyloid beta (Aβ) deposition. assessed apolipoprotein E (ApoE) brain...
An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-making–related disorders, including addiction. Although external globus pallidus (GPe) critical for action selection, which harbors enriched astrocytes, the role GPe astrocytes involved action-selection strategies remained unknown. Using vivo calcium signaling with fiber photometry, we found substantially attenuated astrocytic activity during learning compared to learning. The support vector machine...
The carboxy-DHED (cx-DHED) is a derivative of DHED which improves memory impairment. Carboxyl modification increases solubility in water, indicating that its bioavailability higher than those DHED. cx-DHED expected to have better therapeutic effects on Alzheimer's disease In this study, we investigated the and underlying mechanism 5xFAD AD model mice. several behavioral tests such as Y-maze, passive avoidance, Morris water maze test, deficits improved significantly cx-DHED-treated Tg mice...
Hyposmia in Alzheimer's disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which one of the toxic factors upregulated AD, has been identified many studies, even peripheral areas olfactory system, pathology involving sensory neurons (OSNs) remains poorly understood.Here, we focused on and delved deeper into direct relationship between pathophysiological behavioral results using odorants. We also confirmed histologically...
Alzheimer’s disease (AD) is one representative dementia characterized by the accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) in brain, resulting cognitive decline memory loss. AD associated with neuropsychiatric symptoms, including major depressive disorder (MDD). Recent studies showed a reduction mGluR5 expression brains stress-induced mice models individuals MDD compared to controls. In our study, we identified depressive-like behavior impairment mouse model...
Alcohol use disorder (AUD) has been associated with the development of neurodegenerative diseases, including Alzheimer's disease (AD). However, recent studies demonstrate that moderate alcohol consumption may be protective against dementia and cognitive decline.We examined astrocyte function, low-density lipoprotein (LDL) receptor-related protein 1 (LRP1), NF-κB p65 IKK-α/β signaling pathways in modulating neuroinflammation amyloid beta (Aβ) deposition. We assessed apolipoprotein E (ApoE)...
Recently, isoflavone derivatives have been shown to neuroprotective effects against neurological disorders. For instance, genistein attenuated the neuroinflammation and amyloid-β accumulation in Alzheimer's disease animal models, suggesting potential for use prevent treat disease.Here, 50 compounds, including derivatives, were constructed screened inhibitory on amyloid-β42 fibrilization oligomerization using high-throughput screening formats of thioflavin T assay multimer detection system,...
Alzheimer’s disease (AD) is characterized by the deposition of extracellular amyloid plaques and intracellular accumulation neurofibrillary tangles (NFT). Amyloid beta (Aβ) tau imaging are widely used for diagnosing monitoring AD in clinical settings. We evaluated pathology a recently developed 6 × Tg − (6 Tg) mouse model crossbreeding 5 FAD mice with expressing mutant (P301L) protein using micro-positron emission tomography (PET) image analysis. PET studies were performed these...
Alzheimer's disease (AD) is a form of dementia associated with abnormal glucose metabolism resulting from amyloid-beta (Aβ) plaques and intracellular neurofibrillary tau protein tangles. In previous study, we confirmed that carboxy-dehydroevodiamine∙HCl (cx-DHED), derivative DHED, was effective at improving cognitive impairment reducing phosphorylated levels synaptic loss in an AD mouse model. However, the specific mechanism action cx-DHED unclear. this investigated how attenuates...
Abstract The external globus pallidus (GPe) is an integrative hub and gateway for behavioral flexibility in reward-related behaviors. However, it remains unknown whether enriched astrocytes the GPe guide flexibility. Here, we trained mice to exhibit goal-directed habitual reward-seeking behaviors using behavior tasks with effort- time-based reward delivery, respectively. Then, examined temporal dynamics of during learning. Overall, were substantially silenced learning compared In timescale...