A5004534607- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Prostate Cancer Treatment and Research
- Thyroid Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Research Studies
- Pituitary Gland Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- Bone health and treatments
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
Medical University of Vienna
2016-2025
University of Vienna
1999-2022
Klinik und Poliklinik für Nuklearmedizin
2012-2022
Guided Therapeutics (United States)
2020
Active Medicine (United Kingdom)
2017
FWF Austrian Science Fund
2016
Universitätszahnklinik Wien
2011
Vienna General Hospital
1996-2011
Friedrich-Alexander-Universität Erlangen-Nürnberg
2007
European Association of Nuclear Medicine
1995-2005
Abstract In melanoma, therapies with inhibitors to oncogenic BRAF V600E are highly effective but responses often short-lived due the emergence of drug-resistant tumor subpopulations. We describe here a mechanism acquired drug resistance through microenvironment, which is mediated by human tumor-associated B cells. Human melanoma cells constitutively produce growth factor FGF-2, activates tumor-infiltrating IGF-1. B-cell-derived IGF-1 critical for melanomas and MEK heterogeneous...
Reflecting one's mental self is a fundamental process for evaluating the personal relevance of life events and moral decision making future envisioning. Although corresponding network has been receiving growing attention, driving neurochemical mechanisms default mode (DMN) remain unknown. Here we combined positron emission tomography functional magnetic resonance imaging to investigate modulations DMN via serotonin-1A receptors (5-HT 1A ), separated 5-HT autoinhibition (dorsal raphe nucleus)...
PET/MRI has recently been introduced into clinical practice. We prospectively investigated the impact of compared with PET/CT, in a mixed population cancer patients, and performed an economic evaluation PET/MRI. Cancer patients referred for routine staging or follow-up by PET/CT underwent consecutive PET/MRI, using single applications [18F]FDG, [68Ga]Ga-DOTANOC, [18F]FDOPA, depending on tumor histology. were rated separately, lesions assessed per anatomic region; based regions,...
Electroconvulsive therapy (ECT) is a potent in severe treatment-refractory depression. Although commonly applied psychiatric clinical routine since decades, the exact neurobiological mechanism regarding its efficacy remains unclear. Results from preclinical and studies emphasize crucial involvement of serotonin-1A receptor (5-HT1A) mode action antidepressant treatment. This includes associations between treatment response changes 5-HT1A function density by antidepressants. Further,...
To determine the value of diffusion-weighted MRI (DWI-MRI) for pretherapeutic imaging fluorodeoxyglucose (FDG)-avid lymphoma and with variable FDG avidity.Treatment-naïve patients who were referred whole-body staging included in this prospective study. Group A FDG-avid (e.g., Hodgkin, diffuse large B-cell, follicular lymphoma), whereas B avidity [e.g., extranodal marginal zone B-cell mucosa-associated lymphoid tissue (MALT)]. All underwent DWI-MRI 18F-FDG- positron emission...
Background: Recently it has been demonstrated that after selenium (Se) supplementation in autoimmune thyroiditis (AIT) patients, there was a significant decrease of thyroid peroxidase (TPO) autoantibody (TPOAb) levels. The aim our study to evaluate the immunological benefit Se administration unselected AIT patients and thus address question whether should generally be recommended for patients. Methods: Thirty-six consecutive (aged 19–85 years) were included present study. In addition their...
AimsChronic heart failure (CHF) is frequently associated with a decreased haemoglobin level, whereas the mechanism remains largely unknown.
To assess whether multiparametric (18)fluorodeoxyglucose positron emission tomography magnetic resonance imaging (MRI) (MP (18)FDG PET-MRI) using dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted (DWI), three-dimensional proton MR spectroscopic (3D (1)H-MRSI), and (18)FDG-PET enables an improved differentiation of benign malignant breast tumors.Seventy-six female patients (mean age, 55.7 years; range, 25-86 years) with abnormality (BI-RADS 0, 4-5) were included in this...
To determine the value of diffusion-weighted MRI (DWI-MRI) for treatment response assessment in 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-avid lymphoma.Patients with FDG-avid Hodgkin (HL) or non-Hodgkin lymphoma (NHL) at pretherapeutic 18F-FDG-PET/CT, who had also undergone whole-body DWI-MRI, were included this prospective study. Depending on histologic subtype, patients received different systemic regimens, and follow-up DWI-MRI 18F-FDG-PET/CT performed one more time points, depending clinical...
The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) F-FDG PET/computed (CT), with regard the assessment nodal extranodal involvement, in patients Hodgkin lymphoma non-Hodgkin lymphoma, restriction FDG-avid subytpes.Patients histologically proven were enrolled prospective, institutional review board-approved study. After a single injection, consecutively underwent...
Background: This study investigated the performance of ensemble learning holomic models for detection breast cancer, receptor status, proliferation rate, and molecular subtypes from [18F]FDG-PET/CT images with without incorporating data pre-processing algorithms. Additionally, machine (ML) were compared conventional analysis using standard uptake value lesion classification. Methods: A cohort 170 patients 173 cancer tumors (132 malignant, 38 benign) was examined [18F]FDG-PET/CT. Breast...
The nervous and circulatory system interconnects the various organs of human body, building hierarchically organized subsystems, enabling fine-tuned, metabolically expensive brain-body inter-organ crosstalk to appropriately adapt internal external demands. A deviation or failure in function a single organ subsystem could trigger unforeseen biases dysfunctions entire network, leading maladaptive physiological psychological responses. Therefore, quantifying these networks healthy individuals...
<i>Aim:</i> To investigate the possible changes in renal tubular function severe short-term hypothyroidism using <sup>99m</sup>Tc-MAG<sub>3</sub> renography. <i>Methods:</i> 27 consecutive thyroidectomized patients (7 males and 20 females) aged 19–79 (mean 53) years were included present study. renography was performed all before after thyroid hormone replacement therapy. In addition, <sup>51</sup>Cr-EDTA clearance serum creatinine...
Adrenal cortical carcinoma (ACC) is a rare malignant neoplasm with poor prognosis. Radical surgery of the primary tumor and local as well distant recurrence only effective treatment, requires accurate early localization recurrent tumors. In this regard, we prospectively scanned 10 patients ACC, 8 during follow-up 2 at work-up. all PET scans from neck to upper thighs were obtained 45 minutes after injection 370 MBq [18F]FDG. Reading was done visually, investigator blinded results other...
Routine measurement of serum calcitonin (CT) has been recently proposed for all patients with neoplastic thyroid disease to detect clinically occult medullary carcinoma (MTC). Data on the prevalence elevated CT levels in nonneoplastic or healthy subjects have not reported date. Four hundred and fourteen consecutive suspected 362 controls underwent examination basal CT. Whenever was 10 pg/ml more, a pentagastrin (PG) stimulation test performed. Twenty-eight 414 (6.8%) showed levels, 15 them...
Melanomas contain distinct cell subpopulations. Several of these subpopulations, including one expressing CD20, may harbor stem cell-like or tumor-initiating characteristics. We hypothesized that patients at high risk disease recurrence could benefit from an adjuvant anti-CD20 therapy. Therefore, we initiated a small pilot trial to study the effect antibody rituximab in group melanoma with stage IV metastatic who had been rendered without evident by way surgery, chemotherapy and/or radiation...
Abstract Suffering from anhedonia, patients with major depressive disorder (MDD) exhibit alterations in several parts of the serotonergic neurotransmitter system, which are turn involved reward processing. However, previous investigations serotonin transporter (SERT) focused on regional differences varying results depending clinical syndrome. Here, we aimed to describe system MDD a network level by evaluating SERT associations across brain regions. Twenty medication free depression and 20...
The aim of this study was to assess the diagnostic performance simultaneous whole-body Ga-DOTANOC PET/MRI compared with PET/CT for detection distant metastatic disease in patients well-differentiated neuroendocrine tumors (NETs).Patients histologically proven, NET (G1 or G2) were included prospective, institutional review board-approved study. Patients underwent and subsequent after a single tracer injection on same day staging restaging purposes. Images evaluated presence lesions by 2 rater...