A5087789652- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Immune cells in cancer
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Lung Cancer Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Medical Imaging Techniques and Applications
- Cancer Risks and Factors
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Advanced Breast Cancer Therapies
- Radiation Therapy and Dosimetry
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
- Ear and Head Tumors
Sahlgrenska University Hospital
2024-2025
University of Gothenburg
2024-2025
University of British Columbia
2021-2024
Uppsala University Hospital
2024
Aga Khan University
2008-2022
Centre for Health Evaluation and Outcome Sciences
2021-2022
Memorial Sloan Kettering Cancer Center
2011-2019
Aga Khan University Hospital
2007-2014
Aga Khan University Hospital Nairobi
2007-2008
St Thomas' Hospital
1988
Importance The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with recurrence and death patients early-stage triple-negative (TNBC) who are not treated adjuvant or neoadjuvant chemotherapy is unclear. Objective To study the TIL survival among TNBC were locoregional therapy but no chemotherapy. Design, Setting, Participants Retrospective pooled analysis individual patient-level data from 13 participating centers North America (Rochester, Minnesota;...
Colony-stimulating factor-1 receptor (CSF-1R) signaling promotes an immune suppressive microenvironment enriched in M2 macrophages. Given that CSF-1R inhibitors are under investigation clinical trials, including breast cancer, expression and association with biomarkers could identify patients who derive greater benefit from combination immunotherapies. TIMER2.0 bc-GenExMiner v4.7 were used to assess the correlation of
Background: Androgen receptor (AR) has emerged as a significant favorable prognostic indicator in estrogen expressing (ER+) breast cancer (BCa); however, its clinical and biological relevance triple negative (TNBC) association with stem cell (CSC) markers remain ambiguous. Methods: We examined the immunohistochemical expression of AR cohort stage I-III TNBC cases (n = 197) long-term follow-up data (mean 53.6 months). Significance was correlated biomarkers including (CD44, CD24, ALDH1), basal...
Abstract Background: The prognostic value of stromal tumor-infiltrating lymphocytes (TILs) as a biomarker for triple-negative breast cancer (TNBC) has been extensively demonstrated in patients (pts) receiving (neo)adjuvant systemic therapy. In addition, several small studies suggest that subset pts with early-stage TNBC and high TILs have excellent long-term outcomes, even the absence therapy [1-3]. However, data on absolute risk recurrence according to TIL levels are limited critical inform...
BACKGROUND: Androgen receptor (AR) has emerged as a significant prognostic marker in early breast cancer (BCa). Association of AR with stem cell (CSC) markers BCa is unknown. Aim the present study was to evaluate immunohistochemical expression AR, CD44, CD24 and ALDH1 cohort Pakistani patients diagnosed invasive correlate 5- year disease free survival. PATIENTS AND METHODS: We evaluated formalin fixed paraffin embedded archival blocks 166 cases primary (stage I-III) correlated...
The aim of this epidemiological study was to establish the laterality breast cancer (BC) and its association with size, receptor status primary tumor bone metastasis (BM) in a local population.This retrospective included cases BC from Jan-2009 Dec-2011 who were referred for metastatic work up or follow survey Technetium-99m MDP scan (BS) Nuclear Medicine Department Karachi Institute Radiotherapy (KIRAN). A total 384 patients out 521 all reviewed age, size (PTS), laterality, like estrogen...
The LUMINA trial demonstrated a very low local recurrence rate in women ≥55 years with low-risk luminal A breast cancer (defined as grade I-II, T1N0, hormone receptor positive, HER2 negative and Ki67 index ≤13.25%) treated breast-conserving surgery endocrine therapy (but no other systemic therapy), supporting the safe omission of radiation these women. Here we describe protocol for assessment, companion diagnostic used to guide adjuvant radiotherapy.Ki67 immunohistochemistry was performed on...
Preclinical studies suggest that some effects of conventional chemotherapy, and in particular, gemcitabine, are mediated through enhanced antitumor immune responses. The objective this study was to use material from a randomized clinical trial evaluate whether patients with preexisting infiltrates responded better treatment gemcitabine + docetaxel (GD) compared alone. Formalin fixed, paraffin-embedded breast cancer tissues SBG0102 phase 3 randomly assigned GD or were used....
Basal-like breast cancer is an aggressive molecular subtype associated with younger age and early relapse. Most cases lack expression of oestrogen receptor (ER), progesterone receptor, human epidermal growth factor 2, limiting targeted therapeutic options. defined by the genes in outer/basally located epithelial layer mammary glands, including those encoding cytokeratin (CK) 5 CK14, (EGFR). SRY-box transcription 10 (SOX10), for which there a readily available immunohistochemical stain,...
Purpose: Granulocyte colony-stimulating factor (G-CSF) and hypoxia modulate the tumour immune microenvironment. In model systems, hypoxia-induced carbonic anhydrase IX (CAIX) has been associated with G-CSF responses, including M2 polarization of macrophages. We investigated whether these associations exist in human breast cancer specimens, their relation to subtypes, clinical outcome. Methods: Using validated protocols prespecified scoring methodology, expression on carcinoma cells CD163...
<b>Background/Aims: </b> Although laparoscopic cholecystectomy (LC) has become the procedure of choice for cholelithiasis in general population, many consider cirrhosis as a relative or absolute contraindication surgery. The aim this study was to confirm safety LC cirrhotic patients our set-up. <b> Materials and Methods:</b> This is retrospective case series including all with who underwent gallstones from January 2000 December 2006 at institution. Data were analyzed Child class, indication...
Abstract Precise biomarkers are needed to guide better diagnostics and therapeutics for basal-like breast cancer, which DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has been recently reported by the Clinical Proteomic Tumor Analysis Consortium as most specific biomarker. We evaluated DNA-PKcs expression in clinically-annotated cancer tissue microarrays correlated results with immune (training set: n = 300; validation 2401). Following a pre-specified study design per REMARK...
Abstract Background: The benefit of regional nodal irradiation (RNI) in patients with low burden metastatic axillary disease was established MA.20 showing that randomized to receive adjuvant whole breast (WBI) plus RNI experienced a significantly better free survival (DFS) and distant (DDFS) compared those who received WBI alone this advantage maintained the hormone receptor negative subgroup. Stromal tumor infiltrating lymphocytes (sTILs) have shown prognostic predictive value HER2 positive...
Abstract Introduction Optimal follow-up of patients with sentinel lymph node (SLN) positive trunk melanoma is uncertain. Completion dissection (CLND) no longer indicated and instead these are followed by ultrasound examinations. However, exactly which nodal basins to examine has not been established, should it be focused on the site or all lymphoscintigraphy? This study aims describe patterns recurrences in melanoma. Method Patients diagnosed undergoing wide local excision SLN biopsy at...
Abstract Introduction Sentinel lymph node (SLN) biopsy is the current standard for prognostication and guiding therapeutics in early breast cancer. Recent level I evidence suggests that omitting up-front axillary surgery select low-risk patients oncologically safe. The relevance of identifying clinicopathological factors selection at low risk SLN metastasis cannot be understated. Limited exists regarding capacity tumor localization within as a factor metastasis. This study aims to evaluate...