A5061822404- Breast Cancer Treatment Studies
- Cutaneous Melanoma Detection and Management
- Economic and Financial Impacts of Cancer
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Immunotherapy and Immune Responses
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Diversity and Career in Medicine
- Innovations in Medical Education
- Ethics in medical practice
- Pancreatic and Hepatic Oncology Research
- Surgical Simulation and Training
- Hospital Admissions and Outcomes
- Nonmelanoma Skin Cancer Studies
- CAR-T cell therapy research
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- COVID-19 and healthcare impacts
- Gastrointestinal Tumor Research and Treatment
- Medical Education and Admissions
- Polyomavirus and related diseases
- Multiple and Secondary Primary Cancers
- Ethics in Clinical Research
Loma Linda University
2016-2025
Loma Linda University Health Care
2016-2024
Cleveland Clinic
2021
American College of Surgeons
2020
Loma Linda University Medical Center
2005-2020
Watson Clinic
2019
University of Chicago
2013-2016
NorthShore University HealthSystem
2016
University of Chicago Medical Center
2013-2014
Michigan Center for Translational Pathology
2011
The majority of cancer patients respond poorly to either vaccine or checkpoint blockade, and even the combination both. They are often resistant high doses radiation therapy as well. We examined prognostic markers immune cell infiltration in pancreatic cancer. Patients with low CD8+ T PD-L1 expression (CD8+ TloPD-L1hi) experienced poor outcomes. developed a mouse tumor fragment model trackable antigen (SIYRYYGL SIY) mimic TloPD-L1hi cancers. Tumors arising from fragments contained few cells,...
The suspension of elective operations in March 2020 to prepare for the COVID-19 surge posed significant challenges resident education. To mitigate potential negative effects on surgical education, it is important quantify how pandemic influenced operative volume.To examine association with general residents' experience by postgraduate year (PGY) and case type evaluate if certain institutional characteristics were associated a greater decline volume.This retrospective review included logs...
Objective: Single-center studies have demonstrated that resection of cavity shave margins (CSM) halves the rate positive and re-excision in breast cancer patients undergoing partial mastectomy (PM). We sought to determine if these findings were externally generalizable across practice settings. Methods: In this multicenter randomized controlled trial occurring 9 centers United States, stage 0–III PM randomly assigned either CSM (“shave” group) or not (“no shave” group). Randomization...
Abstract Background In patients with melanoma, in-transit metastasis (ITM) can develop. This study aimed to identify the risk for a first recurrence of ITM and associated predictive clinical factors in large international cohort melanoma. Methods Patients primary cutaneous melanoma who underwent wide local excision (WLE) sentinel lymph node biopsy (SLNB) were identified from Sentinel Lymph Node Working Group (SLNWG) database between January 1993 February 2023. Predictive analyzed. Results...
Hepatic resection has become the mainstay of treatment for both primary and certain secondary malignancies. Outcomes after hepatic have significantly improved with advances in surgical anesthetic techniques perioperative care. Metabolic functional changes are unique cause significant challenges management. In-depth understanding physiology is essential to properly address postoperative issues. Strategies implemented period improve outcomes include adequate nutritional support, proper...
Background: Sarcopenia has been associated with increased adverse outcomes after major abdominal surgery. defined as decreased muscle volume or fatty infiltration may be a proxy for frailty. In conjunction other preoperative clinical risk factors, radiographic measures of sarcopenia using both size and density enhance prediction pancreaticoduodenectomy (PD) malignancy. Methods: Preoperative computed tomography (CT) scans patients undergoing PD malignancy were analyzed from prospective...
<h3>Importance</h3> Recent recognition of the overdiagnosis and overtreatment ductal carcinoma in situ (DCIS) detected by mammography has led to development clinical trials randomizing women with non–high-grade DCIS active surveillance, defined as imaging surveillance or without endocrine therapy, vs standard surgical care. <h3>Objective</h3> To determine factors associated underestimation invasive cancer patients a diagnosis that would preclude surveillance. <h3>Design, Setting,...
Gastric cancer (GC) peritoneal carcinomatosis (PC) is associated with a poor prognosis. Although grade, histology, and stage are PC, the cumulative risk of PC when multiple factors present unknown. This study aimed to develop GCPC score based on individual demographic/tumor characteristics.Patient-level data (2004-2014) from California Cancer Registry were reviewed by creating keyword search algorithm identify patients gastric PC. Multivariable logistic regression was used assess...
Studies have demonstrated comparable outcomes between laparoscopic and open resection of gastrointestinal stromal tumor (GIST). We sought to compare among robotic, laparoscopic, gastric GIST in the era expanding minimally invasive surgery.
Abstract Background For melanoma patients with a positive axillary SLN, the extent of ALND remains controversial, debate over whether level III dissection is needed. Methods We queried our IRB approved prospective database for SLN who had I/II only, and compared recurrence complication rates to existing literature. Results Between 1998 2008, 270 285 ALNDs SLN. Median number removed was 2, while median involved 1 (range 1–4). An average 18.7 nodes/ALND were removed, 13% having non‐SLN....
Abstract Strategies to identify tumors at highest risk for treatment failure are currently under investigation patients with bladder cancer. We demonstrate that flow cytometric detection of poorly differentiated basal tumor cells (BTCs), as defined by the co-expression CD90, CD44 and CD49f, directly from early stage (T1-T2 N0) patient-derived xenograft (PDX) engraftment in locally advanced (T3-T4 or N+) predict poor prognosis Comparative transcriptomic analysis isolated PDXs indicates unique...
Abstract Introduction Fragmentation of care (FC, the receipt at > 1 institution) has been shown to negatively impact cancer outcomes. Given multimodal nature breast treatment, we sought identify factors associated with FC and its effects on survival patients. Methods A retrospective analysis was performed surgically treated, stage I–III patients in 2004–2020 National Cancer Database, excluding neoadjuvant therapy recipients. Patients were stratified into two groups: or non-FC care....