A5035651464- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Berberine and alkaloids research
- Viral Infectious Diseases and Gene Expression in Insects
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Angiogenesis and VEGF in Cancer
- Pharmacological Effects of Natural Compounds
- Diet and metabolism studies
- Animal testing and alternatives
- Natural Antidiabetic Agents Studies
- Advances in Cucurbitaceae Research
- Flavonoids in Medical Research
- Nuclear Structure and Function
- Cardiac Fibrosis and Remodeling
- Gut microbiota and health
- Genomics, phytochemicals, and oxidative stress
- Alkaloids: synthesis and pharmacology
- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- Renin-Angiotensin System Studies
- Botulinum Toxin and Related Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
University of Pavia
2020-2023
Isfahan University of Medical Sciences
2018
Diabetic retinopathy (DR), one of the most common complications diabetes mellitus, is characterized by degeneration retinal neurons and neoangiogenesis. Until today, pharmacological approaches for DR are limited focused on counteracting end-stage this neurodegenerative disease, therefore efforts should be carried out to discover novel targets useful prevent development. Hyperglycemia a major risk factor endothelial dysfunction vascular complication, which subsequently may trigger...
Ischemic stroke is the most common cause of adult disability and one leading causes death worldwide, with a serious socio-economic impact. In present work, we used new thromboembolic model, recently developed in our lab, to induce focal cerebral ischemic (FCI) rats without reperfusion. We analyzed selected proteins implicated inflammatory response (such as RNA-binding protein HuR, TNFα, HSP70) via immunohistochemistry western blotting techniques. The main goal study was evaluate beneficial...
Chronic conditions requiring long-term rehabilitation therapies, such as hypertension, stroke, or cancer, involve complex interactions between various systems/organs of the body and mutual influences, thus implicating a multiorgan approach. The dual-flow IVTech LiveBox2 bioreactor is recently developed inter-connected dynamic cell culture model able to mimic organ crosstalk, since cells belonging different organs can be connected grown under flow in more physiological environment. This study...
The RNA-binding protein HuD has been shown to play a crucial role in gene regulation the nervous system and is involved various neurological psychiatric diseases. In this study, through creation of an interaction network on its potential targets, we identified strong association between several diseases system. Specifically, focused relationship brain-derived neurotrophic factor (BDNF), whose implicated neuronal development, survival, function. To better investigate given that previously...
The animal thromboembolic model of ischemia perfectly mimics human ischemic stroke which remains the leading cause disability and mortality in humans. development new treatment strategies was therefore imperative. purpose this study is to improve rats order design experiments that use motor tests, are accordance with 3R principles prevent complications maintain same size infarct repeatedly. Tail vein dye application, a protective skull mask stress minimization protocol were used as...
Medical Devices Made of Substances (MDMS) are increasingly used in the healthcare system alongside classic medicinal products and constitute an important field experimentation innovation biomedical field. In fact, these rapidly establishing themselves as a valuable therapeutic resource available various forms including, but not limited to, creams, syrups, nasal or oropharyngeal sprays, eye drops. MDMS marketed to treat different diseases advantages benefits use can be claimed, once proven...