A5060358060- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Protease and Inhibitor Mechanisms
- Diet and metabolism studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuropeptides and Animal Physiology
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Dental materials and restorations
- Anesthesia and Neurotoxicity Research
- Biofield Effects and Biophysics
- Autoimmune and Inflammatory Disorders Research
- Toxin Mechanisms and Immunotoxins
- Spinal Cord Injury Research
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Ubiquitin and proteasome pathways
- Pituitary Gland Disorders and Treatments
- Fatty Acid Research and Health
- Synthesis and Biological Evaluation
Medical University of Silesia
2014-2025
University of Silesia in Katowice
2023
Polish Academy of Sciences
2014
Wroclaw Medical University
2011-2012
Sulfonylureas (SUs)-a class of drugs primarily used to treat type 2 diabetes-have recently attracted interest for their potential anticancer properties. While some studies have explored the chemical modification or design new SU derivatives, our work instead centers on biological evaluations all commercially available SUs in combination with doxorubicin (DOXO). These antidiabetic agents act by stimulating insulin secretion via KATP channel inhibition, and because channels share structural...
The blood-brain barrier is the structure (BBB), which isolates central nervous system from external environmental. During a stroke, BBB gets damaged, accompanied by changes in concentrations and distributions of claudin-5, occludin, ZO-1, other building blocks BBB. aim this study was to assess selected components BBB-occludin, zonulin (ZO-1)-and define potential relationship between these three substances type location extent infarct focus, neurological/functional status acute phase disease,...
Ischemic stroke is the most common cause of adult disability and one leading causes death worldwide, with a serious socio-economic impact. In present work, we used new thromboembolic model, recently developed in our lab, to induce focal cerebral ischemic (FCI) rats without reperfusion. We analyzed selected proteins implicated inflammatory response (such as RNA-binding protein HuR, TNFα, HSP70) via immunohistochemistry western blotting techniques. The main goal study was evaluate beneficial...
KIR genes coding for natural killer cell immunoglobulin-like receptors, KIR, influence the effector and regulatory function of NK cells as well some subpopulations T lymphocytes (e.g. CD4+CD28-KIR+) depending on presence ligands (particularly HLA-C molecules). KIR-KIR ligand interaction may lead to development autoimmune disorders, including rheumatoid arthritis (RA). However, their role in response RA patients methotrexate therapy is not known. KIR-ligand (HLA-C C1/C2 allomorphs) genotyping...
This work presents the results of examination HeLa cell line exposure on ELF-EMF (extremely low-frequency electromagnetic field). In particular, relationship between exposition time and death. The death hallmarks were examined by estimation levels selected proteins - FACL4 (a protein that is a part ferroptosis pathway) CK18 (Cytokeratin related to necrosis apoptosis pathways) in proposed model workers exposed week.
Objectives: Ketogenic diet (KD) is a high-fat-content with insufficiency of carbohydrates that induces ketogenesis. Besides its anticonvulsant properties, many studies have shown neuroprotective effect in central nervous system, but influence on peripheral system has not been studied yet. We examined the KD regeneration nerves adult rats.Methods: Fifty one rats were divided into three experimental (n = 15) and control 6) groups. Right sciatic nerve was crushed animals kept standard (ST...
Spinal cord injury (SCI) causes disturbances of motor skills. Free radicals have been shown to be essential for the development spinal trauma. Despite some progress, until now no effective pharmacological therapies against SCI verified. The purpose our experiment was investigate neuroprotective effects ebselen on experimental SCI. Twenty-two rats subjected were randomly with further treatment (n = 10) or intragastric administration (10 mg/kg) immediately and 24 hours after Behavioral changes...
The multifaceted nature of subarachnoid hemorrhage (SAH) pathogenesis is poorly understood. To date, no pharmacological agent has been found to be efficacious for the prevention brain injury when used acute SAH intervention. This study was undertaken evaluate beneficial effects low-dose neuroprotective minocycline on microvascular ultrastructures that have not studied in detail. We using an vivo prechiasmatic rodent model. analyzed qualitative and quantitative ultrastructural morphology...
Reperfusion stroke therapy is a modern treatment that involves thrombolysis and the mechanical removal of thrombus from extracranial and/or cerebral arteries, thereby increasing penumbra reperfusion. After reperfusion therapy, 46% patients are able to live independently 3 months after onset. MicroRNAs (miRNAs) essential regulators in development ischemia/reperfusion injury efficacy applied treatment. The first aim this study was examine change serum miRNA levels via next-generation...
This study conducted a comparative analysis of fatty acids (FAs) concentration derived from polar (PL) and non-polar (NPL) lipids in the liver muscle tissues rats mice. The objective was to elucidate species-specific differences tissue FA distribution. Employing targeted GC/MS-based methodology, aimed provide insights into conserved aspects lipid metabolism, thereby enhancing future experimental design, linked with comprehension interactions between diet, health. Results revealed markedly...
<title>Abstract</title> <bold>Background: </bold>Hypertension (HTN) and diabetes mellitus (DM) are associated with cognitive impairment dementia. Antihypertensive treatment may improve functioning. Elevated blood glucose levels can increase the risk of dementia even in non-DM. Both HTN DM contribute to development Alzheimer’s disease. <bold>Aims:</bold> The aim this study was assess influence vascular factors on cognition. <bold>Methods:</bold> conducted south Poland among rural population...
Abstract The multifaceted nature of subarachnoid hemorrhage (SAH) pathogenesis is poorly understood, to date, no pharmacological agent has been found be efficacious for the prevention brain injury when used acute SAH intervention. This study was undertaken evaluate beneficial effects low-dose neuroprotective minocycline on microvascular ultrastructures which are not studied in detail. We using vivo pre-chiasmatic rodent model. analyzed qualitative and quantitative ultrastructural morphology...
Embolization is the preferred method for treating intracranial aneurysms due to its less invasive nature. However, recent findings suggest that even uncomplicated embolization may cause structural damage brain through ischemic or inflammatory mechanisms. This study aimed find possible biomarkers of injury and inflammation in patients suffering from who underwent endovascular treatment by measuring serological markers indicating damage. The involved 26 intravascular stenting unruptured...
Abstract Background and Purpose: The multifaceted nature of Subarachnoid hemorrhage (SAH) pathogenesis is poorly understood. Despite the high morbidity disability rate associated with SAH, to date, no pharmacological agent has been found be efficacious for prevention brain injury when used acute SAH intervention.Methods: We studied using in vivo pre-chiasmatic subarachnoid rodent model. analyzed qualitative quantitative ultrastructural morphology capillaries surrounding neuropil brains...