A5009853761- Chemotherapy-induced cardiotoxicity and mitigation
- Electron Spin Resonance Studies
- Ferrocene Chemistry and Applications
- Photochromic and Fluorescence Chemistry
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Cancer, Hypoxia, and Metabolism
- Metal complexes synthesis and properties
- Autophagy in Disease and Therapy
- Birth, Development, and Health
- Biochemical and Molecular Research
- Plant nutrient uptake and metabolism
- Bioactive Compounds and Antitumor Agents
- Metabolism, Diabetes, and Cancer
- Cancer Treatment and Pharmacology
- Trace Elements in Health
- Circadian rhythm and melatonin
- Synthesis and Characterization of Heterocyclic Compounds
- Nanoplatforms for cancer theranostics
- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Free Radicals and Antioxidants
- Lanthanide and Transition Metal Complexes
University of Łódź
2015-2025
Sulfonylureas (SUs)-a class of drugs primarily used to treat type 2 diabetes-have recently attracted interest for their potential anticancer properties. While some studies have explored the chemical modification or design new SU derivatives, our work instead centers on biological evaluations all commercially available SUs in combination with doxorubicin (DOXO). These antidiabetic agents act by stimulating insulin secretion via KATP channel inhibition, and because channels share structural...
The in vitro anticancer activity of the dinuclear trithiolato-bridged arene ruthenium complex diruthenium-1 (DiRu-1) was evaluated against a panel human cancer cell lines used as models for hepatocellular carcinoma (HepG2 cells), estrogen-responsive breast adenocarcinoma (MCF-7 and triple-negative (MDA-MB-231 cells). DiRu-1 is highly cytotoxic to these lines, demonstrating half-maximal inhibitory concentrations (IC50 ) low-nanomolar range (77±1.4 268.2±4.4 nm). main molecular mechanisms...
Hexokinase 2 (HK2), an enzyme of the sugar kinase family, plays a dual role in glucose metabolism and mediating cancer cell apoptosis, making it attractive target for therapy. While positive HK2 expression usually promotes cells survival, silencing or inhibiting this has been found to improve effectiveness anti-cancer drugs even result death. Previously, benitrobenrazide (BNBZ) was characterized as potent inhibitor with good activity mice, but effect its trihydroxy moiety (pyrogallol-like)...
The synthesis of four cymantrene-5-fluorouracil derivatives (1-4) and two cymantrene-adenine (5 6) is reported. All the compounds were characterized by spectroscopic methods crystal structure (1 6), together with previously described compound C was determined X-ray crystallography. While 1 6 crystallized in triclinic P-1 space group, monoclinic P2₁/m group. newly synthesized 1-6 tested cymantrene B for their vitro antiproliferative activity against seven cancer cell lines (MCF-7, MCF-7/DX,...
With the aim of contributing to knowledge about their potential therapeutic activity, we determined biological activities cyanidin and its selected O-glycosides in relation erythrocytes (RBCs) human dermal vascular endothelial cells (HMEC-1). Furthermore, on basis changes physical/functional properties cells, structure-activity relationships compounds were determined. Concerning erythrocytes, analyzed antioxidant activity impact RBCs' shape transmembrane potential. The compounds' cytotoxic...
In plants, phosphorylated MAPKs display constitutive nuclear localization; however, not all studied plant species show co-localization of activated to mitotic microtubules. The mitogen-activated protein kinase (MAPK) signaling pathway is involved only in the cellular response biotic and abiotic stress but also regulation cell cycle development. role formation a spindle has been widely MAPK was found be indispensable for unperturbed course division. Here we localization (dually at their TXY...
The study investigated the structure-activity relationship of newly synthesized dye-linker-macrocycle (DLM) conjugates and effect each component on various biological properties, including cytotoxicity, cellular uptake, intracellular localization, interaction with DNA photodynamic effects. were by combining 1,8-naphthalimide thioxanthone dyes 1,4,7,10-tetraazacyclododecane (cyclen) 1-aza-12-crown-4 (1A12C4) using alkyl linkers different lengths. results revealed significant differences in...
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The biological properties of doxyl stearate nitroxides (DSs): 5-DS, Met-12-DS, and 16-DS, commonly used as spin probes, have not been explored in much detail so far. Furthermore, the influence DSs on cellular changes induced by anticancer drug doxorubicin (DOX) has yet investigated. Therefore, we examined cytotoxicity their ability to induce cell death fluidity lipid peroxidation (LPO) plasma membrane immortalised B14 fibroblasts, a model neoplastic cells, susceptible DOX-induced changes....
The study aimed to evaluate the cytotoxic activity of newly synthesized Dye-Linker-Macrocycle (DLM)type conjugates on both non-cancerous and cancerous cell lines investigate structure-activityrelationship. results revealed significant variations in among different conjugateseries, regardless type intercalating dye used, crown ether exhibited significantlyhigher cytotoxicity compared cyclic polyamine conjugates. conjugation dyes with crownethers proved be an effective strategy for improving...