A5059589515- Bone Tissue Engineering Materials
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Advanced NMR Techniques and Applications
- Electron Spin Resonance Studies
- Glioma Diagnosis and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical Chemistry and Sensors
- Immunotherapy and Immune Responses
- Nanoparticles: synthesis and applications
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Power System Optimization and Stability
- Electrospun Nanofibers in Biomedical Applications
- Cell Image Analysis Techniques
- Power Systems Fault Detection
- Cancer Immunotherapy and Biomarkers
- Nanocluster Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Smart Grid Security and Resilience
- MRI in cancer diagnosis
- Crystal Structures and Properties
- Indian Economic and Social Development
- Antimicrobial agents and applications
Yale University
2020-2025
Resonance Research (United States)
2021-2024
National Institute of Science and Technology
2020-2021
King Edward Memorial Hospital and Seth G.S. Medical College
2020
Pondicherry University
2014-2017
Delhi Technological University
2016
Central Pollution Control Board
2015
Panjab University
2006
Background Image-guided tumor ablation is the first-line therapy for early-stage hepatocellular carcinoma (HCC), with ongoing investigations into its combination immunotherapies. Matrix metalloproteinase (MMP) inhibition demonstrates immunomodulatory potential and reduces HCC growth when combined ablative treatment. Purpose To evaluate effect of incomplete cryoablation or without MMP on local immune response in residual tumors a murine model. Materials Methods Sixty 8- to 10-week-old female...
An in situ synthesis method for preparing silver nanoclusters (AgNCs) embedded chitosan-polyethylene glycol (CS-PEG) membranes is disclosed. The aim to develop implantable multifunctional devices biofilm inhibition and drug release reduce percutaneous device related complications (PDRCs). A multiple array of characterization techniques confirmed the formation fluorescent AgNCs with sizes ∼3 nm uniformly distributed CS-PEG matrix their active role determining fraction interconnectivity...
ABSTRACT Cellular metabolism is inextricably linked to transmembrane levels of proton (H + ), sodium (Na and potassium (K ) ions. Although reduced sodium‐potassium pump ‐K ATPase) activity in tumors directly disturbs Na K levels, this dysfunction a result upregulated aerobic glycolysis generating excessive cytosolic H (and lactate) which are extruded acidify the interstitial space. These oncogene‐directed metabolic changes, affecting intracellular , can be further exacerbated by upregulation...
Hydroxyapatite unit cell reflecting the preferential occupancy of Sr<sup>2+</sup> at Ca<sup>2+</sup> (2) site. Crystal framework represents bonding and orientation PO<sub>4</sub><sup>3−</sup> with their relative OH<sup>−</sup> bonding, which proposes thermodynamically stable configuration.
An engineered metallic nanostructure is an excellent candidate for "theranosis" of cancer, having intrinsic properties multimodal imaging and therapy. Toward this target, the development silver-neodymium bimetallic nanoparticles (Ag-Nd BNPs) via microwave-assisted polyol synthesis presented. The resultant Ag-Nd BNPs exhibit good monodispersity with average size 10 nm, fluorescence in near-infrared (NIR) region, magnetic properties. also validate MRI, CT, NIR trimodal ability enunciate...
Monodispersed chitosan-capped bimetallic nanoparticles (BNPs) of AgGd have been synthesized for "cancer theranosis" through environmentally benign microwave-assisted polyol synthesis. In the present article, we report one-pot synthesis BNPs with varied Ag:Gd molar ratios via coreduction Ag+ and Gd3+ ions. Studies reveal a well-dispersed average size 12 nm also presence face-centered cubic (FCC) Ag Gd components within individual crystal. Chitosan (CS) biopolymer, as capping agent facilitates...
Glioblastoma progression involves multifaceted changes in vascularity, cellularity, and metabolism. Capturing such complexities of the tumor niche, from core to periphery, by magnetic resonance imaging (MRI) spectroscopic (MRSI) methods has translational impact. In human-derived glioblastoma models (U87, U251) we made simultaneous longitudinal measurements perfusion (F p ), permeability (K trans volume fractions extracellular (v e ) blood spaces dynamic contrast enhanced (DCE) MRI,...
The role of cerium in the formation stable β-Ca3(PO4)2/c-CeO2 composites and their structural analysis with varied compositional ratios were investigated. composite was attempted through an situ precipitation technique, gradual changes during heat treatments to yield pure form presented. found Ce3+ Ce4+ oxidation states composites. prefers occupy Ca2+(1), Ca2+(2), Ca2+(3) sites β-Ca3(PO4)2, whereas, beyond saturation occupancy limit, excess crystallize thermodynamically cubic ceria (c-CeO2)....
We report results of studies relating to the fabrication a flexible, disposable, and label free biosensing platform for detection cancer biomarker (carcinoembryonic antigen, CEA). Polyaniline (PANI) has been electrochemically deposited over gold sputtered paper (Au@paper) covalent immobilization monoclonal carcinoembryonic antibodies (anti-CEA). The bovine serum albumin (BSA) used blocking nonspecific binding sites at anti-CEA conjugated PANI/Au@Paper. PANI/Au@Paper, anti-CEA/PANI/Au@Paper,...
Accurate imaging of the structural and functional state biological targets is a critical task. To amend paucities associated with individual imaging, there high interest to develop multifunctional theranostic devices for cancer diagnosis therapy. Herein, chitosan coated silver/dysprosium bimetallic nanoparticles (BNPs) were synthesized through green chemistry route characterization results inferred that BNPs are crystalline, spherical, size ∼10 nm. High-angle annular dark-field scanning...
The effect of SiO2 content on the phase behavior TiO2 during heat treatment was investigated in present study. Sol–gel synthesis employed to form five different TiO2–SiO2 binary oxides. characterization results confirmed vital role reducing crystallite growth TiO2, which instrumental restricting anatase (a-TiO2) rutile (r-TiO2) transformation. It revealed from techniques that size exceeding ∼50 nm induced a-TiO2 r-TiO2 transition. Heat beyond 1100 °C resulted gradual conversion and moreover...
Abstract A unique feature of the tumor microenvironment is extracellular acidosis in relation to intracellular milieu. Metabolic reprogramming tumors results overproduction H + ions (and lactate), which are extruded from cells support survival and progression. As a result, transmembrane pH gradient (ΔpH), representing difference between (pH i ) e ), posited be larger compared with normal tissue. Controlling has promise as potential therapeutic target cancer it plays an important role...
Extremely small paramagnetic iron oxide nanoparticles (FeMNPs) (<5 nm) can enhance positive magnetic resonance imaging (MRI) contrast by shortening the longitudinal relaxation time of water (T1), but these experience rapid renal clearance. Here, protein (MPNPs) are synthesized from protein-conjugated citric acid coated FeMNPs (c-FeMNPs) without loss T1 MRI properties and tagged with fluorescent dye (f-MPNPs) for optical cerebrovascular imaging. The c-FeMNPs shows average size 3.8 ± 0.7 nm...
Abstract Under normal conditions, high sodium (Na + ) in extracellular e and blood b compartments low Na intracellular milieu i produce strong transmembrane (ΔNa mem weak transendothelial end gradients respectively, these manifest the cell membrane potential ( V m as well blood–brain barrier (BBB) integrity. We developed a 23 Na) magnetic resonance spectroscopic imaging (MRSI) method using an intravenously-administered paramagnetic polyanionic agent to measure ΔNa . In vitro Na-MRSI...
Abstract A detailed structural analysis on the in situ synthesized β‐Ca 3 (PO 4 ) 2 /α‐Fe O composites is demonstrated. Compositional ratios, influence and occupancy of iron at lattice, oxidation state are derived from analytical techniques involving XRD, FT‐IR, Raman, refinement powder X‐ray diffraction photoelectron spectroscopy. Iron exists Fe 3+ throughout investigated systems favors its Ca 2+ (5) site until critical limit, thereafter crystallizes as α‐Fe ambient conditions. lattice...