A5029349375- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Bone and Dental Protein Studies
- Bone health and treatments
- Oral and Maxillofacial Pathology
- dental development and anomalies
- Bone Tissue Engineering Materials
- Soft tissue tumor case studies
- TGF-β signaling in diseases
- Bone Tumor Diagnosis and Treatments
- Graphene and Nanomaterials Applications
- Mesenchymal stem cell research
- Axon Guidance and Neuronal Signaling
- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Heterotopic Ossification and Related Conditions
- Medical Imaging and Pathology Studies
- Ophthalmology and Visual Impairment Studies
- Carbon and Quantum Dots Applications
- Cancer-related gene regulation
- Oral microbiology and periodontitis research
- Tissue Engineering and Regenerative Medicine
- Intraocular Surgery and Lenses
- Nanocluster Synthesis and Applications
- Oral and gingival health research
Second Affiliated Hospital of Zhejiang University
2024-2025
Zhejiang University
2025
Eye Center
2024
Peking University People's Hospital
2024
Jilin University
2015-2024
National Engineering Research Center for Information Technology in Agriculture
2024
Beijing Academy of Agricultural and Forestry Sciences
2024
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Peking University
2024
In this article, graphene quantum dots (GQDs) with tunable surface chemistry (increasing oxidation degree) were prepared by an efficient two-step method. The GQDs have fluorescence induced the degree of oxidation, fine solubility, high stability and applicable up-conversion photoluminescence (PL). PL mechanism was investigated based on structure behaviors. More importantly, acid–base response property can be applied as pH sensors.
This study demonstrates high contrast and sensitivity by designing a dual-emissive hydrogel particle system, whose two emissions respond to pH temperature strongly independently. It describes the photoluminescence (PL) response of poly(N-isopropylacrylamide) (PNIPAM)-based core/shell nanoparticles with dual emission, which is obtained emulsion polymerization potassium persulfate, consisting thermo- pH-responsive copolymers PNIPAM poly(acrylic acid) (PAA). A red-emission rare-earth complex...
The biocompatibility of biomaterials is essentially for its application. aim current study was to evaluate the poly(lactic-co-glycolic acid) (PLGA)/gelatin/nanohydroxyapatite (n-HA) (PGH) nanofibers systemically provide further rationales application composite electrospun fibers as a favorable platform bone tissue engineering. PGH scaffold with diameter ranging from nano- micrometers fabricated by using electrospinning technique. Subsequently, we utilized confocal laser scanning microscopy...
Recent studies have demonstrated that erythropoietin (EPO) has extensive nonhematopoietic biological functions. However, little is known about how EPO regulates bone formation, although several suggested can affect homeostasis. In this study, we investigated the effects of on communication between osteoclasts and osteoblasts through ephrinB2/EphB4 signaling pathway. We found slightly promotes osteoblastic differentiation with increased expression EphB4 in ST2 cells. Nfatc1 ephrinB2 but...
Purpose To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing lens specimen. Methods A young Chinese male presented with progressively deteriorating vision in his right eye subsequent history inoculation. He was diagnosed toxic cataract, underwent phacoemulsification surgery. Anterior capsule, nucleus, cortex specimens from patient (designated as PT_CAP, PT_PHACO, PT_CTX, respectively) age-related...
The prospective study is aimed to determine the clinical outcomes of plate-haptic diffractive multifocal toric intraocular lens (IOL) implantation in cataract patients with long axial length and corneal astigmatism. Visual outcomes, defocus curves, contrast sensitivity, rotational stability, vector changes refractive astigmatism patient satisfaction were assessed over 3 months. Vector analysis was performed by Alpins method. A total 36 eyes (18 patients) underwent surgery AT LISA 909 M IOL....
Background: Repair of nonunion critical-sized bone defects is a significant clinical challenge all over the world. Construction osteogenic microenvironment that provides osteoconductive and osteoinductive signals leading strategy. Materials methods: In present study, ascorbic acid (AA) β-glycerophosphate disodium salt hydrate (β-GP) modified biomimetic gelatin/hydroxyapatite (GH) nanofibrous scaffolds were developed by electrospinning. Then crosslinked N-hydroxysulfo-succinimide sodium (NHS)...
We previously found that disruption of two type I BMP receptors, Bmpr1a and Acvr1, respectively, in an osteoblast-specific manner, increased bone mass mice. BMPR1B, another receptor, is also capable binding to ligands transduce signaling. However, little known about the function BMPR1B bone. In this study, we investigated phenotype Bmpr1b null mice impacts loss on osteoblasts osteoclasts. deletion resulted osteopenia 8-week-old male mice, was transient gender specific. The decreased neither...
It is a challenge for dentists to save dental pulp in patients with disease without resorting root canal therapy. Formation of tertiary dentin maintain vitality key odontoblast response injury. Vascular endothelial growth factor (VEGF) the most potent angiogenic and vasculogenic involved formation. was hypothesized that VEGF may be used treat diseases such as pulpitis. To explore this hypothesis, first step assess whether affects cells promote reparative In current study, an AdCMV‑hVEGF...
Low-grade myofibroblastic sarcoma (LGMS) is a distinct mesenchymal malignancy. The tumor may occur at variety of sites, but particularly associated with the head and neck. Of two maxillary sarcomas that were analyzed in present study, one was misdiagnosed as an inflammatory during pre-operative excision biopsy, later presented different immunophenotype upon recurrence. Representative paraffin blocks from formalin-fixed tissues selected each patient designated case 1 2. Immunohistochemical...
Osteoblasts and osteoclasts are well orchestrated through different mechanisms of communication during bone remodeling. Previously, we found that osteoclast-specific disruption one the BMP receptors, Bmpr1a, results in increased osteoblastic formation mice. We hypothesized BMPR1A signaling regulates production either membrane bound proteins or secreted molecules regulated osteoblast differentiation. In our current study, co-cultured wild-type osteoblasts with control lacking activity. loss...
Simvastatin is considered as a stimulator for bone formation. However, the half-life simvastatin generally 2 hours, which means, it difficult to maintain biologically active in vivo. To overcome this limitation, we created system slowly release vitro and We constructed poly(lactic-co-glycolic acid)/hydroxyapatite nano-fibrous scaffold carry simvastatin. Releasing assays showed that was released from acid)/hydroxyapatite/simvastatin quickly within - 15 days, small amounts continued be through...
To investigate the involvement of ephrinB2 in periodontal tissue remodeling compression areas during orthodontic tooth movement and effects compressive force on EphB4 expression osteoblasts osteoclasts.A rat model experimental was established to examine histological changes localization compressed tissues movement. RAW264.7 cells ST2 cells, used as precursor osteoclasts osteoblasts, respectively, were subjected vitro. The gene ephrinB2, well bone-associated factors including Runx2, Sp7,...
Inflammatory osteolysis poses a significant worldwide threat to public health. However, current monotherapies, which target either the prevention of inflammatory response or attenuation osteoclast (OC) formation, have limited efficacy due complexity bone immune system being overlooked. Herein, by means modifying salmon calcitonin (sCT), multifunctional nano-system (AuNDs-sCT) was designed synergistically inhibit OC differentiation and reverse microenvironment against osteolysis. On one hand,...