A5058222954- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
Sheffield Hallam University
2020-2023
PerkinElmer (United Kingdom)
2023
Mass spectrometry imaging (MSI) is an established analytical tool capable of defining and understanding complex tissues by determining the spatial distribution biological molecules. Three-dimensional (3D) cell culture models mimic pathophysiological environment in vivo tumors are rapidly emerging as a valuable research tool. Here, multimodal MSI techniques were employed to characterize novel aggregated 3D lung adenocarcinoma model, developed group tissue. Regions tumor heterogeneity hypoxic...
Osteosarcoma (OS) is the most common primary bone malignancy and largely effects adolescents young adults, with 60% of patients under age 25. There are multiple cell models OS described in vitro that express specific genetic alterations sarcoma. In work reported here, mass spectrometry imaging (MSI) modalities were employed to characterise two aggregated cellular formed using MG63 SAOS-2 lines. Phenotyping metabolite activity within aggregoid was achieved a comparison data human tissue...
Extracellular vesicles (EVs) are lipid bilayer structures released by all cells that mediate cell-to-cell communication via the transfer of bioactive cargo. Because natural origin EVs, their efficient uptake recipient cells, capacity to stabilize and transport biomolecules potential for cell/tissue targeting preferential cancer they have enormous bioengineering into improved targeted drug delivery systems. In this work, we investigated use laser ablation inductively coupled plasma mass...