A5081083064- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Superconducting Materials and Applications
- Acute Myeloid Leukemia Research
- Gyrotron and Vacuum Electronics Research
- Acute Lymphoblastic Leukemia research
- Magnetic confinement fusion research
- Cerebrovascular and Carotid Artery Diseases
- Advanced X-ray Imaging Techniques
- Plasma Diagnostics and Applications
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Oral and Maxillofacial Pathology
- DNA Repair Mechanisms
- Multiple Myeloma Research and Treatments
- TGF-β signaling in diseases
- Cancer therapeutics and mechanisms
- Retinoids in leukemia and cellular processes
- Salivary Gland Tumors Diagnosis and Treatment
- Modeling and Simulation Systems
- Chemical Reactions and Isotopes
- Tuberous Sclerosis Complex Research
European Synchrotron Radiation Facility
2019
University of Oslo
2017
European Organization for Nuclear Research
2007-2017
University of Buenos Aires
2016
European Science Foundation
2011-2014
University of Rome Tor Vergata
1992-2013
GSI Helmholtz Centre for Heavy Ion Research
2004-2006
Associazione Nazionale Medici Cardiologi Ospedalieri
2006
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2005
CEA Paris-Saclay - Etablissement de Saclay
2005
In this paper the influence of betatron coupling on transverse beam emittances is described using resonance driving terms formalism. Betatron and vertical dispersion generated by magnetic installation errors are major sources emittance. A new scheme for minimizing latter presented here, together with results from measurements carried out in 2010 at ESRF electron storage ring, which provided emittance about 4.4 pm, a record low machine. Two schemes automatic compensation introduced insertion...
Summary FLT3 internal tandem duplication (ITD) mutations are frequently detected at diagnosis in cytogenetically normal acute myeloid leukaemia (CN‐AML) and predict unfavourable outcome. ITD is an unstable aberration may be lost or acquired relapse. Recent whole genome sequencing studies have suggested that + ve AML relapse evolve from small subclones undetectable by routine polymerase chain reaction (PCR). We developed a patient‐specific real‐time quantitative‐PCR (RQ‐PCR) to implement...
Beam lifetime in storage rings and colliders is affected by, among other effects, lattice nonlinearities. Their control are of great benefit to the dynamic aperture an accelerator, whose enlargement leads general more efficient injection longer lifetime. This article describes a procedure evaluate correct unwanted nonlinearities by using turn-by-turn beam position monitor data, which evolution previous works on resonance driving terms (RDTs). Effective sextupole magnetic errors tilts at ESRF...
Recently, resonance driving terms were successfully measured in the CERN SPS and BNL RHIC from Fourier spectrum of beam position monitor (BPM) data. Based on these measurements a new analysis has been derived to extract truly local observables BPM These are called since they share some similarities with global terms. In this paper we derive analytically present experimental sextupolar RHIC. Nondestructive using ac dipoles also presented.
Proton beams were successfully steered through the entire ring of CERN Large Hadron Collider (LHC) on September 10th 2008. A reasonable lifetime was achieved for counterclockwise beam, namely beam 2, after radiofrequency capture particle bunch established. This provided unique opportunity acquiring turn-by-turn betatron oscillations a maximum 90 turns right at injection. Transverse coupling not corrected and chromaticity estimated to be large. Despite this largely constrained scenario,...
Hypochromic anemia is at times attributable to nondiagnosed celiac disease. The aim of this study was define the correlates disease in anemic adults without overt malabsorption.One hundred patients with hypochromic and diarrhea underwent a complete diagnostic work-up, including screening for disease, i.e., upper endoscopy duodenal biopsy search antiendomysium antibodies.Patients were from two different Divisions analyzed as single group because they not significantly any variable. 10...
Betatron coupling is usually analyzed using either matrix formalism or Hamiltonian perturbation theory. The latter less exact but provides a better physical insight. In this paper direct relations are derived between the two formalisms. This makes it possible to interpret approach in terms of resonances, as well use results both formalisms indistinctly. An measure complete and its determinant from turn-by-turn data presented. Simulations methodical accelerator design MAD-X, an tracking...
High levels of O6-alkylguanine-DNA-alkyltransferase (OGAT) can, at least in part, account for tumor cell resistance to O6-alkylguanine alkylating agents, including triazene compounds. A pilot clinical study indicates that dacarbazine can induce a marked decrease leukemic blasts patients affected by acute myelogenous leukemia (AML) with low pretreatment OGAT activity. In this we show synergistic antitumor effect between cisplatin (CDDP) and temozolomide (an vitro active analog dacarbazine),...
The multiturn extraction from a circular particle accelerator is performed by trapping the beam inside stable islands of horizontal phase space. In general, crossing resonance order $n$, $n+1$ beamlets are created whenever stable, whereas if unstable split in $n$ parts. Islands generated nonlinear magnetic fields, realized means given tune variation so to cross adiabatically resonance. Experiments at CERN Proton Synchrotron carried out 2007 gave evidence protons trapped while one-third and...
Measurement and correction of focusing errors is great importance for performance machine protection circular accelerators. Furthermore LHC needs to provide equal luminosities the experiments ATLAS CMS. High demands are also set on speed optics commissioning, as foreseen operation with ${\ensuremath{\beta}}^{*}$-leveling luminosity will require many operational optics. A fast measurement $\ensuremath{\beta}$-function around a storage ring usually done by using measured phase advance between...
The influence of linear betatron coupling due to constant-in-time skew quadrupolar fields on the transverse emittances is discussed using both a simplified model smooth circular accelerator and more realistic strong-focusing lattice with localized sources (thin lens). New formulas for coupled are derived that include initial emittances, strengths, tune distance from resonance. By powerful Lie algebra resonance driving terms formalism, equivalent provide better understanding some...
Recent measurements of resonance terms suggested the extension existing technique to measure magnet strengths from turn-by-turn beam position monitor data. This article describes algorithm infer strength variation along ring and reports on first measurement. Both software written for analysis data can be particularly useful in commissioning period an accelerator order find magnets with wrong or polarities as well large magnetic errors.
Beam optics control is of critical importance for machine performance and protection. Nowadays, turn-by-turn (TbT) beam position monitor (BPM) data are increasingly exploited as they allow fast simultaneous measurement various quantities. Nevertheless, so far the best documented uncertainty measured $\ensuremath{\beta}$-functions about 10\mbox{\textperthousand} rms. In this paper we compare ESRF storage ring from two different TbT techniques---the N-BPM Amplitude methods---with ones inferred...
Abstract In 2020 the ESRF storage ring will be upgraded to a Hybrid Multi Bend Achromat (HMBA) lattice. The commissioning of new require dedicated tools, either updated from existing ones or newly developed. Most software and procedures were tested on before its decommissioning. particular we present experiments first-turn steering beam accumulation, check magnet polarity calibration, injection tuning. use control-system simulator proved crucial for debugging development control system, as...
Cytogenetic analyses of bone marrow cells were carried out by means direct technique and short-term cultures in 25 acute promyelocytic leukaemia (APL) patients. 16 affected the hypergranular form 9 M3-variant. The t(15;17) was documented at diagnosis 15 In addition, 2 cases, which an M3 morphology a normal karyotype on preparation found diagnosis, disclosed chromosome anomaly cultured relapse, concomitance with change blast to However, consistent feature 5 patients analysed preparations only...