A5056618351- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Neurobiology and Insect Physiology Research
- Sinusitis and nasal conditions
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- Cancer-related gene regulation
- Telomeres, Telomerase, and Senescence
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics and Phylogenetic Studies
- Salivary Gland Disorders and Functions
- Research in Cotton Cultivation
- Pneumothorax, Barotrauma, Emphysema
- Cancer-related molecular mechanisms research
- Effects of Radiation Exposure
- Metastasis and carcinoma case studies
- COVID-19 and healthcare impacts
- Cancer Diagnosis and Treatment
SUNY Downstate Health Sciences University
2017-2022
State University of New York
2020-2022
Pulmonary and Critical Care Associates
2020
First Hospital of Jilin University
2013
Jilin University
2013
University of Portsmouth
2013
Washington University in St. Louis
2013
Duke Medical Center
2013
Chinese University of Hong Kong
2009
Prince of Wales Hospital
2009
Background and Objectives: This study aimed to identify demographic clinical factors at the time of critical care consultation associated with mortality or intensive unit acceptance in a predominantly Afro-Caribbean population during first wave COVID19 pandemic. Materials Methods: retrospective, single-center observational cohort included 271 patients who received consult between March 11 April 30, 2020 pandemic State University New York Downstate Health Sciences University. Results: Of...
Abstract Chronic rhinosinusitis (CRS) is a common condition associated with inflammation and tissue remodeling of the nose paranasal sinuses, frequently occurring nasal polyps allergies. Here we investigate protease profile in tissues plasma from control non-CRS patients CRS patients. Gene expression for several cytokines, proteases, antiproteases was quantified subjects polyps. Elevated S100A9, IL1A, MMP3, MMP7, MMP11, MMP25, MMP28, CTSK observed compared to tissue. Tissue protein analysis...
In this report, the first amphibian glucagon receptor (GluR) cDNA was characterized from liver of frog Rana tigrina rugulosa . Functional expression GluR in CHO and COS‐7 cells showed a high specificity towards human with an EC 50 value 0.8±0.5 nM. The binding radioiodinated to displaced dose‐dependent manner only its antagonist (des‐His 1 ‐[Nle 9 ‐Ala 11 16 ]) IC values 12.0±3.0 7.8±1.0 nM, respectively. did not display any affinity fish GLP‐1s, peptides derived two species teleost fishes...
The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role the suppression of this tumor. In order to study effect restoration NPC cells, full-length human was transfected into a cell line, CNE1. Four individual clones with differential levels protein expression, were selected for further studies. introduction CNE1 cells induced growth through G0/G1 cycle arrest; however, rate not correlated expression. To whether...
In a recent study, it was shown that DNA damaging agent cisplatin-induced growth arrest and cell death in cancer cells by pathway sharing some of the characteristics replicative senescence. The aim this study to determine role p53, p21WAF1 p16INK4A proteins alternative route additional human lines. After exposure cisplatin, all lines underwent expressed senescence marker senescence-associated beta-galactosidase, but showed none features apoptosis. However, there no change p53 protein...
Citrobacter koseri is a gram-negative bacillius that belongs to the Enterobacteriaceae family. It an uncommon pathogen typically causes meningitis and brain abscesses in children, however central nervous system (CNS) infections are rarely found adults. We present case of C. immunocompetent adult secondary intestinal micro-perforation caused by Strongyloides A 76-year-old man admitted for asthma exacerbation developed septic shock. lumbar puncture revealed bacterial meningitis. Blood CSF...
The LDL receptor-related protein 1 (LRP1) partakes in metabolic and signaling events regulated a tissue-specific manner. function of LRP1 airways has not been studied. We aimed to study the smoke-induced disease. found that bronchial epithelium patients with chronic obstructive pulmonary disease airway mice exposed smoke had increased expression. then knocked out human epithelial cells vitro club mice. In vitro, knockdown decreased cell migration transforming growth factor β activation....
1 in 8 were harmed (pressure sores) 16 (tracheal tube obstruction) 11.6% higher risk of pressure sores 6.2% tracheal obstruction Acute respiratory distress syndrome (ARDS) is a type acute diffuse, inflammatory lung injury leading to increased pulmonary vascular permeability and loss aerated tissue. Clinically, this process manifests as hypoxemia, radiographic opacities, physiologic dead space, decreased compliance.1 It common disease affecting many 10% intensive care unit (ICU) admissions,...
NNT color recommendationYellow (unclear if benefits) Summary headingNo difference in time to resolution of diabetic ketoacidosis; hypoglycemic episodes; or mortality between intravenous regular insulin and subcutaneous rapid-acting analogs Benefits No one was helped with infusion when compared regard number episodes percentages Harms (NNH) harmed (no adverse events other than hypoglycemia reported) Efficacy endpoints Time ketoacidosis, hypoglycemia, all-cause Harm Hypoglycemia Who the...
Rationale: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, has led to a global health crisis unlike any our contemporaries have witnessed before. SUNY Downstate Health Sciences University was designated as one of three COVID-19-only hospitals on March 28, 2020. This retrospective, single-center observational study grants unique perspective surrounding the experience critical care service at public institution serving predominantly...
The use of cisplatin as a potential radiosensitizer in nasopharyngeal carcinoma (NPC) has produced encouraging results clinical trials. In order to provide information on improving the design treatments, we investigated effect dose, and time interval sequence between administration radiation cell survival two NPC lines, CNE1 SUNE1. When was applied first, an exposure 24 h resulted up 2.6-fold increase death 7-fold (cell after cisplatin/cell plus radiation) cisplatin-radiation combination...
Abstract Rationale: Lung cancer is a leading cause of cancer-related deaths. Smoking major risk factor for initial and subsequent lung especially in active smokers. Treatment depends on whether it synchronous or metachronous. We report rare case triple metachronous review literature patients with cancers. This will be the second reported cancer. Patient concerns: A 60-year-old male, smoker diabetes mellitus, chronic obstructive pulmonary disease (COPD) peripheral arterial presented cough...
There is a knowledge gap of specific characteristics linked to disease severity the different COVID-19 waves, especially in underserved populations. We compared demographic and clinical factors associated with SARS-CoV-2-infected patients admitted intensive care unit (ICU) during Omicron Alpha waves.An observational study comparing two waves was conducted Brooklyn, NY. Twenty-seven ICU positive test result period November 1, 2021, January 31, 2022, ("Omicron wave") were 271 who received...
Sepsis is one of the leading causes morbidity and mortality within healthcare system remains a diagnostic therapeutic challenge. A major issue in diagnosis sepsis understanding pathophysiologic mechanism, which revolves around host immune activation dysregulated responses. African Americans are more likely to experience severe with higher rates compared general population. This pilot study characterized multiple inflammatory markers proteases plasma primarily American Afro-Caribbean patients...