A5034623238- Pregnancy and preeclampsia studies
- Nuclear Structure and Function
- RNA Research and Splicing
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Genomics and Chromatin Dynamics
- Infection Control and Ventilation
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- COVID-19 and healthcare impacts
- Pregnancy and Medication Impact
- Microtubule and mitosis dynamics
- Plant and Biological Electrophysiology Studies
- Infant Nutrition and Health
- Slime Mold and Myxomycetes Research
- Renal and related cancers
- Urinary Tract Infections Management
- Literature and Cultural Memory
- Cardiovascular Issues in Pregnancy
- Cellular Mechanics and Interactions
- Agricultural Economics and Policy
- Folklore, Mythology, and Literature Studies
- Nanoparticle-Based Drug Delivery
- Language Development and Disorders
- COVID-19 Clinical Research Studies
University of Delaware
2020-2025
University of Wyoming
2016-2020
Newark Hospital
2020
City University of New York
1996-2015
Introduction: Monologues in the Crib Katherine Nelson Part I: Constructing a World 1. Monologue as Representation of Real-Life Experience 2. Narrative Recreation Jerome Bruner and Joan Lucariello 3. Problem-Solving Carol Fleisher Feldman II: Language 4. Development Text-Forming Function Elena Levy 5. Speech Genre Julie Gerhardt 6. Reenvoicement Dialogue John Dore III: Self 7. Monologue, Dialogue, Regulation Rita Watson 8. Linguistic Construction Time 9. from Psychoanalytic Perspective Daniel...
Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for vaccination against COVID-19 and protein replacement therapies. LNPs enhance stability, circulation time, cellular uptake, preferential to specific tissues compared with no carrier platform. However, are only in the beginning stages of development safe effective placenta treat placental dysfunction. Here, we develop that enable high levels trophoblasts
Key developmental processes that occur on the subcellular and cellular level or in occluded tissues are difficult to access, let alone image analyze. Recently, culturing living samples within polydimethylsiloxane (PDMS) microfluidic devices has facilitated study of hard-to-reach events. Here, we show an early diverging land plant, Physcomitrella patens, can be continuously cultured PDMS chambers. Because chambers bonded a coverslip, it is possible P. patens development at high resolution...
Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for vaccination against COVID-19 and protein replacement therapies. LNPs enhance stability, circulation time, cellular uptake, preferential to specific tissues compared with no carrier platform. However, yet be developed safe effective the placenta a method treat placental dysfunction. Here, we develop that enable high levels of trophoblasts in vitro vivo toxicity. We conducted Design Experiments explore...
Abstract During pregnancy, the maternal immune system adapts to balance tolerance of semi-allogenic fetus while protecting from pathogens. Dysregulated activity at maternal-fetal interface contributes pregnancy complications, such as recurrent loss and preeclampsia. Compared healthy placentas, preeclamptic placentas exhibit increased pro-inflammatory signaling, including a predominance inflammatory macrophages, leading impaired tissue remodeling restricted blood flow. However, precise...
How nuclear size is regulated relative to cell a fundamental biological question. Reductions in both and sizes during
The placental extracellular matrix (ECM) dynamically remodels over pregnancy and in disease. How these changes impact barrier function is poorly understood as there are limited
COVID-19 is a disease that manifests itself in multitude of ways across wide range tissues. Many factors are involved, and though impressive strides have been made studying this novel very short time, there still great deal unknown about how the virus functions. Clinical data has crucial for providing information on progression determining risk factors. However, mechanisms leading to multi-tissue pathology yet be fully established. Although insights from SARS-CoV-1 MERS-CoV valuable, it...
ABSTRACT As the current COVID-19 pandemic illustrates, not all hospitals and other facilities are equipped with enough personal protective equipment to meet demand in a crisis. Healthcare workers around world utilize N95 masks protect themselves their patients, yet during this global they forced re-wear what is intended be single-use masks. This poses significant risk these healthcare along populations trying protect. Ultraviolet germicidal irradiation (UVGI) has been validated previously as...
SUMMARY How nuclear size is regulated relative to cell a fundamental biological question. Reductions in both and sizes during Xenopus laevis embryogenesis provide robust scaling system study mechanisms of regulation. To test if the volume embryonic cytoplasm limiting for growth, we encapsulated gastrula stage nuclei droplets defined using microfluidics. Nuclei grew reached new steady-state as function cytoplasmic volume, supporting component mechanism control. Through biochemical...
SUMMARY Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis organisms ranging from yeast to vertebrates is that nuclear scales cell size. This implies nuclei may reach steady state sizes set by limiting cytoplasmic pools of size-regulating components. By monitoring dynamics early sea urchin embryos, we found undergo substantial growth each interphase, reaching a maximal prior mitosis declined steadily over the course development....
How nuclear size is regulated relative to cell a fundamental biological question. Reductions in both and sizes during Xenopus laevis embryogenesis provide robust scaling system study mechanisms of regulation. To test if the volume embryonic cytoplasm limiting for growth, we encapsulated gastrula stage nuclei droplets defined using microfluidics. Nuclei grew reached new steady-state as function cytoplasmic volume, supporting component mechanism control. Through biochemical fractionation,...