A5082184862- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Wnt/β-catenin signaling in development and cancer
- Connexins and lens biology
- 3D Printing in Biomedical Research
- Vascular Anomalies and Treatments
- Nanoparticle-Based Drug Delivery
- Climate Change and Health Impacts
- Cellular Mechanics and Interactions
- Vascular Malformations and Hemangiomas
- Renal and related cancers
- Angiogenesis and VEGF in Cancer
- Infection Control in Healthcare
- Connective tissue disorders research
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Childhood Cancer Survivors' Quality of Life
- Hemostasis and retained surgical items
University of Delaware
2018-2022
Yale University
2016
Morphogenesis of the vascular system is strongly modulated by mechanical forces from blood flow. Hereditary hemorrhagic telangiectasia (HHT) an inherited autosomal-dominant disease in which arteriovenous malformations and telangiectasias accumulate with age. Most cases are linked to heterozygous mutations Alk1 or Endoglin, receptors for bone morphogenetic proteins (BMPs) 9 10. Evidence suggests that a second hit results clonal expansion endothelial cells form lesions poor mural cell coverage...
Premature male neonates are at a greater risk of developing bronchopulmonary dysplasia (BPD). The reasons underlying sexually dimorphic outcomes in premature not known. role miRNAs mediating sex biases BPD is understudied. Analysis the pulmonary transcriptome revealed that large percentage angiogenesis-related differentially expressed genes miR-30a targets. We tested hypothesis there differential expression vivo and vitro neonatal human microvascular endothelial cells (HPMECs) upon exposure...
Bronchopulmonary dysplasia (BPD) is a disease with significant sexual dimorphism where males have disadvantage compared their female counterparts. Although mechanisms behind this are poorly understood, sex differences in angiogenesis been identified as one possible source of the male BPD. Pulmonary was assessed vitro using bead sprouting assay pooled or human pulmonary microvascular endothelial cells (HPMECs, 18-19 wk gestation, canalicular stage lung development) standard (sex-hormone...
ABSTRACT As the current COVID-19 pandemic illustrates, not all hospitals and other facilities are equipped with enough personal protective equipment to meet demand in a crisis. Healthcare workers around world utilize N95 masks protect themselves their patients, yet during this global they forced re-wear what is intended be single-use masks. This poses significant risk these healthcare along populations trying protect. Ultraviolet germicidal irradiation (UVGI) has been validated previously as...
Although many factors contribute to the low translational success of pre-clinical data into human trials, one major factor is failure models recapitulate essential physiological components malignant tumors. An important body clinical research indicates that surrounding cellular microenvironment involving stromal tissue, matrix and resident immune system play a critical role in genesis brain tumors diverse types. The presented this paper specifically addresses biomechanical extracellular may...