A5090018213- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Diagnosis and treatment of tuberculosis
- Machine Learning in Bioinformatics
Center for Infection and Immunity of Lille
2024
AgroParisTech
2022-2024
Université Paris-Saclay
2022-2024
Université Paris Cité
2024
Université Bourgogne Franche-Comté
2024
London School of Hygiene & Tropical Medicine
2024
Institut Pasteur de Lille
2024
Écologie, Systématique et Évolution
2022-2024
Centre National de la Recherche Scientifique
2022-2024
CEA Paris-Saclay
2022
Abstract Analysis of genome sequencing data from >100,000 genomes Mycobacterium tuberculosis complex using TB-Annotator software revealed a previously unknown lineage, proposed name L10, in central Africa. Phylogenetic reconstruction suggests L10 could represent missing link the evolutionary and geographic migration histories M. africanum.
Antimicrobial combination therapy is widely used to combat Mycobacterium tuberculosis (Mtb), yet resistance rates continue rise. Mutator strains, with defects in DNA repair genes, are a known source of other bacterial infections, but their global role Mtb remains unclear. Here, we provide comprehensive overview the contribution single nucleotide polymorphisms (SNPs) Repair, Replication, and Recombination (3R) genes Mtb. Through large-scale bioinformatics analysis 53,589 whole-genomes,...
To tackle the spread of tuberculosis (TB), epidemiological studies are undertaken worldwide to investigate TB transmission chains. Clustered regulatory interspaced short palindromic repeats (CRISPR) locus diversity, also called spoligotyping, is a widely used genotyping assay for characterization Mycobacterium complex (MTBC). We compared herein spoligotyping MTBC clinical isolates using membrane-based method (following an initial PCR step) and whole-genome sequencing (WGS)-based (i.e., in...
ABSTRACT Mycobacterium tuberculosis (Mtb) infections result in a wide spectrum of clinical presentations but without proven Mtb genetic determinants. Herein, 234 pulmonary (TB) patients were stratified according to TB disease severity and features explored using whole genome sequencing, including heterologous single nucleotide polymorphism (SNP) calling explore micro-diversity. Clinical isolates from with mild carried mutations genes associated host-pathogen interaction, while those...