Verena Gschiel
A5076349757- Cannabis and Cannabinoid Research
- Polyamine Metabolism and Applications
- Autophagy in Disease and Therapy
- Dietary Effects on Health
University of Graz
2021-2024
Nawi Graz
2024
Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective lifespan-extending effects dietary spermidine, natural autophagy-promoting polyamine. Here, we show that spermidine passes blood-brain barrier in mice increases hippocampal eIF5A hypusination mitochondrial function. Spermidine feeding aged affects behavior homecage environment tasks, improves...
Abstract Caloric restriction and intermittent fasting prolong the lifespan healthspan of model organisms improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection reduced incidence cardiovascular neurodegenerative diseases across species borders. Here, we asked whether cellular physiological consequences caloric depend on metabolism. We report that levels increased upon distinct regimens or in yeast, flies, mice volunteers....