A5018037393- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organometallic Complex Synthesis and Catalysis
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Asymmetric Hydrogenation and Catalysis
- Corrosion Behavior and Inhibition
- Nanocluster Synthesis and Applications
- Chemical Reactions and Isotopes
- Catalysis and Oxidation Reactions
- Cyclopropane Reaction Mechanisms
- Catalytic Processes in Materials Science
- Carbon dioxide utilization in catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Lanthanide and Transition Metal Complexes
- Fluorine in Organic Chemistry
- Inorganic Chemistry and Materials
- Catalytic C–H Functionalization Methods
- Metal-Catalyzed Oxygenation Mechanisms
Stockholm University
2020
Brooklyn College
2014-2018
City University of New York
2014-2018
The Graduate Center, CUNY
2014-2016
University of Castilla-La Mancha
2008-2013
Laboratoire de Chimie Organique
2005
Centre National de la Recherche Scientifique
2005
Universidad de Zaragoza
2005
Heterometallic compounds as anticancer agents demonstrating<italic>in vivo</italic>potential for the first time. Titanocene–gold derivatives: promising candidates renal cancer.
New organometallic gold(III) and platinum(II) complexes containing iminophosphorane ligands are described. Most of them more cytotoxic to a number human cancer cell lines than cisplatin. Cationic Pt(II) derivatives 4 5, which differ only in the anion, Hg2Cl6(2-) or PF6(-) respectively, display almost identical IC50 values sub-micromolar range (25-335-fold active cisplatin on these lines). The gold compounds induced mainly caspase-independent death, as previously reported for related...
We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group carboxylate ligand (mba = -OC(O)-p-C6H4-S-) bound to gold(I)-N-heterocyclic carbene fragments through thiolate group: [(η5-C5H5)2TiMe(μ-mba)Au(NHC)]. The cytotoxicities heterometallic compounds along with those novel monometallic gold-N-heterocyclic precursors [(NHC)Au(mbaH)] have been evaluated against renal, prostate, colon, breast cancer cell lines. highest activity...
We describe a versatile and quick route to cationic gold(i) complexes containing N-heterocyclic carbenes second ancillary ligand (such as phosphanes, phosphites, arsines amines) of interest for the synthesis compounds with potential catalytic medicinal applications. The general synthetic strategy has been applied in preparation novel heterobimetallic ruthenium(ii)-gold(i) that are highly cytotoxic renal cancer Caki-1 colon HCT 116 cell lines while showing synergistic effect being more...
Early–late transition metal TiAu2 compounds [(η-C5H5)2Ti{OC(O)CH2PPh2AuCl}2] (3) and new [(η-C5H5)2Ti{OC(O)-4-C6H4PPh2AuCl}2] (5) were evaluated as potential anticancer agents in vitro against renal prostate cancer cell lines. The significantly more effective than monometallic titanocene dichloride gold(I) [{HOC(O)RPPh2}AuCl] (R = −CH2– 6, −4-C6H4– 7) derivatives lines, indicating a synergistic effect of the resulting heterometallic species. activity on lines (for 5 nanomolar range) was...
This work supports the concept of multifunctional heterometallic compounds as “improved” candidate agents for cancer treatment.
This fluorous biphasic catalysis (FBC) contribution was focused on the synthesis and characterization of new soluble R(f)-Cu(II) carboxylate complexes containing nonfluoroponytailed ligands defines their role as precatalysts for FBC oxidation alkenols alcohols in presence 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO)/O(2). In this approach, we have utilized phase-switching technique Vincent et al. (J. Am. Chem. Soc. 2002, 124, 12942) to solubilize ligands, N-1,4,7-Me(3)TACN, 2,...
A series of new tantalum complexes containing a [NSN]-type amide ligand (2,2′-diamidophenyl sulfide) have been synthesized and characterized. The [TaCp*Cl2{(N-C6H4)2S-κ3-N,S,N}] (1) [TaCp*Me2{(N-C6H4)2S-κ3-N,S,N}] (2) were prepared by reaction 2,2′-diaminophenyl sulfide with [TaCp*Cl4] [TaCp*Me2Cl2], respectively. In addition, [TaCp*MeCl{(N-C6H4)2S-κ3-N,S,N}] (3) [TaCp*(H)2{(N-C6H4)2S-κ3-N,S,N}] (4) 1 AlMe3 NaBEt3H, reactivity these nucleophiles electrophiles was also studied,...
We have used experimental studies and DFT calculations to investigate the Ir
A series of new tantalum-tbcp [tbcp = 2,2′-thiobis(4,6-dichlorophenolato)] and tantalum-tbop [tbop 2,2′-thiobis(6-tert-octylphenolato)] complexes [TaCp*Cl2(κ3-tbop)] (1), [TaCp*Cl2(κ3-tbcp)] (2), [TaCp*Me2(κ3-tbop)] (3), [TaCp*Me2(κ3-tbcp)] (4), [TaCp*Me(κ3-tbop)(OTf)] (OTf triflate) (5), [TaCp*Me(κ3-tbcp)(OTf)] (6), [TaCp*(κ3-tbop)(OTf)2] (7), [TaCp*(κ3-tbcp)(OTf)2] (8) have been synthesized. Insertion processes into the methyl groups complex 3 were not observed upon reaction with CO or...
A series of new cationic aminocarbene tantalum complexes have been synthesized and characterized. significant contribution the anion−cation interaction to stability moiety has revealed. The with a triflate or chloride counterion are very stable, even in air, while corresponding tetraphenylborate derivatives unstable species. This stabilizing behavior can be explained by establishment hydrogen bonds between electronegative atoms anion amine hydroxyl protons cation. presence detected...
The mechanism of the isocyanide migratory insertion into metal–carbon bond monocylopentadienyltantalum dimethyl derivatives with [OSO]2– tridentate phenolate ligands has been investigated DFT calculations. presence both a cyclopentadienyl and ligand complicates usually simple reaction, reaction being coupled fac → mer rearrangement ligand. Two routes have explored for overall process, depending on order steps. Calculations show that dissociative (first rearrangement, then insertion)...
A series of new tantalum complexes containing the κ3O,S,O-type alkoxide ligand from 2,2′-thiodiethanol (tdgolH2) have been synthesized and characterized. The [TaCp*Cl2{[O(CH2)2]2S-κ3O,S,O}] (1) [TaCp*Me2{[O(CH2)2]2S-κ3O,S,O}] (2) were prepared by reaction with [TaCp*X4] (X = Cl, Me). dihydride complex [TaCp*H2{[O(CH2)2]2S-κ3O,S,O}] (3) its analogue 2,2′-thiobis(6-tert-octylphenolate) (4) respective dichlorides 2 equiv NaBHEt3. In addition, [TaCp*Me(TfO){[O(CH2)2]2S-κ3O,S,O}] (5)...