A5048777468- Metal complexes synthesis and properties
- Retinal Diseases and Treatments
- Chemical Synthesis and Analysis
- Ferrocene Chemistry and Applications
- Asymmetric Hydrogenation and Catalysis
- Fluorine in Organic Chemistry
- Organometallic Compounds Synthesis and Characterization
- Organometallic Complex Synthesis and Catalysis
- Retinal and Optic Conditions
- Petroleum Processing and Analysis
- Chemical Synthesis and Reactions
- Metal-Catalyzed Oxygenation Mechanisms
- Retinal Imaging and Analysis
- Porphyrin and Phthalocyanine Chemistry
- Marine Biology and Environmental Chemistry
- Inorganic and Organometallic Chemistry
- Oxidative Organic Chemistry Reactions
- Ocular Diseases and Behçet’s Syndrome
- Analytical chemistry methods development
- Hydrocarbon exploration and reservoir analysis
- Cyclopropane Reaction Mechanisms
- Radioactive element chemistry and processing
- Analytical Chemistry and Chromatography
- Molecular Sensors and Ion Detection
- Enzyme Catalysis and Immobilization
Lawrence Berkeley National Laboratory
2012-2024
University of California, Berkeley
2012-2024
Retina Consultants of Houston
2005-2024
Methodist Hospital
2015-2023
Cornell University
2015-2023
Houston Methodist
2006-2010
Methodist Hospital
2006-2010
Institute of Molecular Science and Technologies
2010
Sorbonne Université
2003-2006
Chimie ParisTech
2003-2006
Bioorganometallic chemistry, a nascent area of organometallic has recently provided significant advancements in structural diversity and molecular recognition studies. This review shows the various novel structures with bioligands other colleagues, as well those from our own In addition, recognition, cornerstone how biological systems operate, now been extended to organometallic, supramolecular host molecules biologically important guest compounds, including ionophores for selective...
The hydride transfer mechanism of the NAD+ model compound 1 to its 1,4-NADH derivative 3 [Eq. (1)] is proposed be a consequence critical role carbonyl group amide coordinate ring-slipped η5- η3-Cp*Rh metal center catalyst [Cp*Rh(bpy)H]+, prepared in situ from 2, while steric effect substituent position, for example, C(O)NEt2, was found totally inhibit this regioselective reduction. bpy=2,2′-bipyridine, Cp*=C5Me5, OTf=trifluoromethanesulfanate.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBioorganotin chemistry. Metabolism of organotin compounds in microsomal monooxygenase systems and mammalsElla C. Kimmel, Richard H. Fish, John E. CasidaCite this: J. Agric. Food Chem. 1977, 25, 1, 1–9Publication Date (Print):January 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://pubs.acs.org/doi/10.1021/jf60209a002https://doi.org/10.1021/jf60209a002research-articleACS PublicationsRequest reuse...
Importance Anti–vascular endothelial growth factor (VEGF) injections in eyes with nonproliferative diabetic retinopathy (NPDR) without center-involved macular edema (CI-DME) reduce development of vision-threatening complications from diabetes over at least 2 years, but whether this treatment has a longer-term benefit on visual acuity is unknown. Objective To compare the primary 4-year outcomes and rates moderate to severe NPDR treated intravitreal aflibercept compared sham. The 2-year...
Cofactor regeneration; i.e., regiospecific conversion of NAD+ to 1,4-NADH, has been extensively studied and is a crucial component in the eventual use 1,4-NADH variety bioorganic synthesis processes involving formation chiral organic compounds. We have reduction model compound, 1-benzylnicotinamide triflate, 1a, using [Cp*Rh(bpy)(H2O)]2+, 2 (Cp* = η5-C5Me5, bpy 2,2'-bipyridyl), as catalyst precursor sodium formate (HCO2Na) hydride source 1:1 H2O/THF found exclusive...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBioorganometallic chemistry. 1. Synthesis, structure, and selectivity in reactions of a nucleobase several nucleosides with (.eta.5-pentamethylcyclopentadienyl)rhodium aqua complexDavid P. Smith, Eduardo Baralt, Bruce Morales, Marilyn M. Olmstead, Marcos F. Maestre, Richard H. FishCite this: J. Am. Chem. Soc. 1992, 114, 26, 10647–10649Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December...
A new paradigm for homogeneous catalytic reactions, fluorous biphasic catalysis, simplifies the separation technique of phase-containing substrate and product from modified fluoroponytailed catalyst, which has total phase solubility, as shown here.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling the dinuclear sites of iron biomolecules: synthesis and properties Fe2O(OAc)2Cl2(bipy)2 its use as an alkane activation catalystJohn B. Vincent, John C. Huffman, G. Christou, Qiaoying. Li, Mark A. Nanny, David N. Hendrickson, Raymond H. Fong, Richard FishCite this: J. Am. Chem. Soc. 1988, 110, 20, 6898–6900Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September...
Two tandem catalysis approaches: first, a cofactor regeneration procedure with an NAD+ model and [Cp*Rh(bpy)H]+, which was formed in situ, provided the 1,4-NADH analogue 1. Cofactor 1 then used horse liver alcohol dehydrogenase (HLADH) for conversion of prochiral ketones into chiral alcohols (e.g. 2→3).
An autoxidation mechanism was involved in the oxidation of alkanes and alkenes with tBuOOH O2 under conditions fluorous biphasic catalysis. The catalytically active complexes are soluble perfluoroheptane form situ from ligand 1 Mn2+ complex 2 polyfluorinated carboxylate ligands (fluoroponytails).
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous catalytic hydrogenation. 6. Synthetic and mechanistic aspects of the regioselective reductions model coal nitrogen, sulfur, oxygen heteroaromatic compounds using (.eta.5-pentamethylcyclopentadienyl)rhodium tris(acetonitrile) dication complex as catalyst precursorEduardo Baralt, Sandra J. Smith, Jamie Hurwitz, Istvan T. Horvath, Richard H. FishCite this: Am. Chem. Soc. 1992, 114, 13, 5187–5196Publication Date (Print):June 1,...
Compromising expensive taste: N-Benzyl-1,4-dihydronicotinamide is a NADH biomimic that cost-efficient alternative to NAD(P)H, but wild-type P450 BM-3 oxidation reactions are not supported by this analogue. However, the activity of W1064S/R966D (see picture) with comparable NADPH. The P450cam analogue was also improved site-directed mutagenesis. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, copy-edited or typeset. They made...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization and comparison of vanadyl nickel compounds in heavy crude petroleums asphaltenes by reverse-phase size-exclusion liquid chromatography/graphite furnace atomic absorption spectrometryRichard H. Fish, John J. Komlenic, Brian K. WinesCite this: Anal. Chem. 1984, 56, 13, 2452–2460Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November...
• An experimental intravitreal sustained-release device containing ganciclovir was used to treat 22 patients with acquired immunodeficiency syndrome—associated cytomegalovirus retinitis. Fourteen eyes were excluded (five not involved and nine macular scarring and/or severe debility). Thirty received the intraocular implant prospectively followed up from 16 419 days (median, 125 days). Twenty-seven (90%) of 30 showed stabilization Nine (33%) 27 reactivation retinitis once empty ganciclovir;...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiomimetic oxidation studies. 5. Mechanistic aspects of alkane functionalization with iron and iron-oxygen (Fe2O Fe4O2) complexes in the presence hydrogen peroxideRichard H. Fish, Mark S. Konings, Kenneth J. Oberhausen, Raymond Fong, Winnie M. Yu, George Christou, John B. Vincent, DeAnna K. Coggin, Robert BuchananCite this: Inorg. Chem. 1991, 30, 15, 3002–3006Publication Date (Print):July 1, 1991Publication History Published online1 May...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular characterization and profile identifications of vanadyl compounds in heavy crude petroleums by liquid chromatography/graphite furnace atomic absorption spectrometryRichard H. Fish John J. KomlenicCite this: Anal. Chem. 1984, 56, 3, 510–517Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous catalytic hydrogenation. 1. Regiospecific reductions of polynuclear aromatic and heteroaromatic nitrogen compounds catalyzed by transition metal carbonyl hydridesRichard H. Fish, Arne D. Thormodsen, Gregg A. CremerCite this: J. Am. Chem. Soc. 1982, 104, 19, 5234–5237Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September...
Molecular recognition, via non-covalent processes such as hydrogen bonding, π−π, and hydrophobic interactions, is an important biological phenomenon for guests, drugs, proteins, other molecules with, example, host DNA/RNA. We have studied a novel molecular recognition process using guests that encompass aromatic aliphatic amino acids [l-alanine, l-glutamine (l-Gln), l-histidine, l-isoleucine (l-Ile), l-leucine (l-Leu), l-phenylalanine (l-Phe), l−proline, l-tryptophan (l-Trp), l-valine...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous catalytic hydrogenation. 2. Selective reductions of polynuclear heteroaromatic compounds catalyzed by chlorotris(triphenylphosphine)rhodium(I)Richard H. Fish, John L. Tan, and Arne D. ThormodsenCite this: J. Org. Chem. 1984, 49, 23, 4500–4505Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November...