A5087067952- Natural product bioactivities and synthesis
- Ginger and Zingiberaceae research
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Bioactive natural compounds
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Phytochemical Studies and Bioactivities
- Food Quality and Safety Studies
- Biochemical Analysis and Sensing Techniques
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Pluripotent Stem Cells Research
- Carbohydrate Chemistry and Synthesis
- melanin and skin pigmentation
- Bioactive Compounds and Antitumor Agents
- Air Quality and Health Impacts
- Protease and Inhibitor Mechanisms
- Natural Antidiabetic Agents Studies
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Pharmacological Effects of Medicinal Plants
Bio-Medical Science (South Korea)
2017-2024
Gyeonggi College of Science and Technology
2015-2018
Gyeonggi Research Institute
2012-2015
Kosin University
2009-2014
Dong-A University
2009-2013
Institute of Science and Technology
2012
Catholic University of Korea
2006-2008
Seoul St. Mary's Hospital
2006-2008
Nanoparticles (NPs) have a greater potential to travel through an organism via inhalation than any other larger particles, and could be more toxic due their surface area specific structural/chemical properties. The aim of this study was evaluate in vitro biological effects various inhalable metallic NPs (TiO2, Ag, Al, Zn, Ni). Human alveolar epithelial cells (A549) were exposed concentrations for 24 h. extent morphological damage the order m-TiO2 > n-TiO2 m-silica ≫ n-Ni ≈ n-Zn n-Ag n-Al...
Abstract Background The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression genes related sarcomatous transdifferentiation. Methods Genes that were differentially expressed between cell lines or tissues cultured normal biliary epithelial (NBE) cells identified using DNA microarray technology. Expressions validated in human cells. Results Using unsupervised hierarchical clustering analysis...
Adenophora triphylla var. japonica (Campanulaceae) is known to have anti‐inflammatory and anti‐tussive effects. Dysfunction of adipocytes adipose tissue in obesity related various inflammatory cytokines or adipokines. In this study, we investigated whether lupenone isolated from A. extract inhibits adipocyte differentiation expression adipogenic marker genes 3T3‐L1 preadipocytes. We demonstrated that resulted a significant reduction lipid accumulation dose‐dependent manner. addition,...
Saponins are a diverse group of biologically functional products in plants. Soyasaponins usually glycosylated, which give rise to wide diversity structures and functions. In this study, we investigated the effects molecular mechanism soyasaponins Aa Ab regulating adipocyte differentiation expression adipogenic marker genes 3T3-L1 adipocytes. dose-dependently inhibited accumulation lipids adiponectin, determination factor 1/sterol regulatory element binding protein 1c, fatty acid-binding 2,...
Kummerowia striata (K. striata) is used as a traditional medicine for inflammation-related therapy. To determine whether it has beneficial anti-melanogenic and anti-oxidant activities, we investigated the biological activities of ethanol extract (EKS) using variety in vitro cell culture model systems. The activity was assessed B16F10 melanoma cells terms melanin synthesis tyrosinase inhibitory activity. assays were performed 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2ʹ-azino-bis...
Saringosterol, a steroid isolated from Sargassum muticum , brown edible alga widely distributed on the seashores of southern and eastern Korea, has been shown to exhibit anti‐obesity effect. In this study, we investigated activity saringosterol through various experiments. The inhibitory effect adipogenesis was evaluated via Oil Red O staining in 3T3‐L1 preadipocytes. After confirming that is not cytotoxic these cells by using 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide...
The human MUC6 gene, which is reported to be expressed in the stomach and gall bladder, clustered on chromosome 11p15.5 with other secreted mucins. In this study, genomic structure of has been analyzed five VNTR (minisatellites; MS1–MS5) were identified. These minisatellites DNA extracted from 1,103 controls, 470 gastric cancer patients, multigenerational families. Five novel found polymorphic transmitted through meiosis by Mendelian inheritance We evaluated allelic variation these determine...
• Korean red ginseng water extract (RGE) from Jinan alleviates atopic dermatitis (AD)-like symptoms in BALB/c mouse model. RGE inhibited expression of proinflammatory cytokines and chemokines. reduced the epidermal thickness mast cell infiltration AD-like skin lesions. improved inflammatory responses via mitogen-activated protein kinases signaling pathway. Atopic (AD) is a chronic disease. traditional medicine. In this study, we estimated effects 1-chloro-2,4-dinitrobenzene (DNCB)-induced...
In order to determine anti-adipogenic effect, this study investigated 1β-hydroxy-2-oxopomolic acid (HOA) isolated from Agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), glucose transporter 4 (GLUT4), adiponectin, fatty acid-binding 2 (aP2), determination factor 1/sterol regulatory element binding 1c (ADD1/SREBP1c), resistin, synthase (Fas) in...
GV1001, a human telomerase reverse transcriptase catalytic subunit-derived 16-mer peptide, has been developed as novel anticancer vaccine against various cancers including pancreatic cancer. In the current study, we demonstrate regulatory roles and mechanisms of GV1001 in endothelial cell responses vitro microvessel sprouting ex vivo. markedly inhibits vascular growth factor-A (VEGF-A)-stimulated permeability, proliferation, migration, invasion, tube formation well outgrowth from rat aortic...
Human beta-defensin (hBD)-2, antimicrobial peptide primarily induced in epithelial cells, is a key factor the innate immune response of respiratory tract. Several studies showed increased defensin levels both inflammatory lung diseases, such as cystic fibrosis, diffuse panbronchiolitis, idiopathic pulmonary fibrosis and acute distress syndrome, infectious diseases. Recently, epidemiologic have demonstrated serious adverse effects particulate air pollution on health, especially people with...