A5019489608- Natural product bioactivities and synthesis
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Phytochemicals and Antioxidant Activities
- Plant Toxicity and Pharmacological Properties
- Phytochemistry and Bioactive Compounds
- Phytochemistry and Biological Activities
- Ginger and Zingiberaceae research
- Phytochemical Studies and Bioactivities
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- melanin and skin pigmentation
- Food Quality and Safety Studies
- Retinoids in leukemia and cellular processes
- Magnolia and Illicium research
- Phytochemical compounds biological activities
- Adipokines, Inflammation, and Metabolic Diseases
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Bioactive natural compounds
- Biological Stains and Phytochemicals
- Biochemical Analysis and Sensing Techniques
Dankook University
2012-2024
University of Ulsan
2024
Asan Medical Center
2024
Ulsan College
2024
Bio-Medical Science (South Korea)
2017-2022
Gyeonggi College of Science and Technology
2015-2018
Gyeonggi Research Institute
2015
Kangwon National University
2008-2011
Kummerowia striata (K. striata) is used as a traditional medicine for inflammation-related therapy. To determine whether it has beneficial anti-melanogenic and anti-oxidant activities, we investigated the biological activities of ethanol extract (EKS) using variety in vitro cell culture model systems. The activity was assessed B16F10 melanoma cells terms melanin synthesis tyrosinase inhibitory activity. assays were performed 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2ʹ-azino-bis...
Saringosterol, a steroid isolated from Sargassum muticum , brown edible alga widely distributed on the seashores of southern and eastern Korea, has been shown to exhibit anti‐obesity effect. In this study, we investigated activity saringosterol through various experiments. The inhibitory effect adipogenesis was evaluated via Oil Red O staining in 3T3‐L1 preadipocytes. After confirming that is not cytotoxic these cells by using 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide...
Atopic dermatitis (AD) is a chronic inflammatory disease. Combretum quadrangulare (C. quadrangulare) used as traditional medicine to improve various pathologies in Southeast Asia. In this study, we investigated the effects of C. ethanol extract (CQ) on 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD like skin lesions BALB/c mice. After administration with CQ (100, 200, and 400 mg/kg) for 6 weeks, symptoms, protein expression, immunoglobulin E (IgE), thymus activation-regulated chemokine...
GV1001, a human telomerase reverse transcriptase catalytic subunit-derived 16-mer peptide, has been developed as novel anticancer vaccine against various cancers including pancreatic cancer. In the current study, we demonstrate regulatory roles and mechanisms of GV1001 in endothelial cell responses vitro microvessel sprouting ex vivo. markedly inhibits vascular growth factor-A (VEGF-A)-stimulated permeability, proliferation, migration, invasion, tube formation well outgrowth from rat aortic...
Tribulus terrestris L. (T. terrestris) has been used as a traditional medicine for the treatment of diuretic, lithontriptic, edema and urinary infections. Previous studies have indicated that it is effective in improving inflammation by regulating tumor necrosis factor‑α (TNF)‑α, interleukin (IL)‑6, IL‑10, nitric oxide (NO) cyclooxygenase (COX)‑2. However, effects mechanism action T. on osteoarthritis (OA) remain unknown. Therefore, present study aimed to evaluate ethanolic extract (ETT)...
Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim this study was to investigate effect an ethanol extract (EAT) on obesity and hyperlipidemia C57BL/6 mice fed high-carbohydrate diet (HCD). First, were divided into five groups (n = 6/group) as follows: normal diet, HCD, HCD+EAT (100, 200, 400 mg/kg/day), which orally administered with EAT daily 84 days. Using...
In this study, we report the anti-proliferative effect and molecular mechanism of Chrysanthemum indicum (C. indicum) on A549 human alveolar basal epithelial cells. We also analyzed changes in C. component profiles due to modifications predrying process, flower size, extraction method. Among varieties tested, high-temperature heat dry (HTD) small biotype followed by methanolic resulted strongest activity extract High-performance liquid chromatography revealed that levels acacetin...
In the course of screening for cosmetic ingredients by measuring antioxidant and antiwrinkle whitening anti-inflammatory activities, skin-related activity was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 2,2 <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:msup> <a:mrow/> <a:mrow> <a:mo>′</a:mo> </a:mrow> </a:msup> </a:math> -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) elastase inhibition, tyrosinase nitric oxide assay. Several...
Spiraea prunifolia has been used in Korean traditional medicine to treat malaria, fever, and emetic conditions. Previous investigation reported that several parts of show various functional effects. However, the effect leaves extract (SPE) on anti-obesity remains unclear. Therefore, we a high-fat diet (HFD)-induced obese mouse model this study investigate effects SPE adipogenesis, lipogenesis, β-oxidation. Oral administration HFD-induced mice considerably reduced body weight, serum levels...
본 연구는 제주도 해변의 벌판에서 드물게 자라는 산유자(Xylosma congesta) 잎 에탄올 추출물의 화장품 기능성 소재로서의 활용 가능성을 알아보기 위하여 cell culture model 및 invitro assay system을 이용하여 미백, 주름개선, 항염증 항산화 활성을 분석하였다. 그 결과 산유자 추출물은 B16F10 세포에 세포독성 없이 효과적으로 α-MSH에 의해 유도된 melanin 합성을 억제함으로써 높은 미백 가지는 것이 관찰되었다. CCD-986SK 세포를 주름개선 활성 능력을 procollagen 합성시험을 통해 분석한 결과, 양성 대조군으로 사용한 TGF-β 만큼은 아니지만 농도별로 각각 120, 122%의 증가시키는 것을 통하여 확인하였다. 또한 RAW 264.7 murine macrophage를 NO 생성 억제능을 분석함으로써 정도를 측정한 LPS에 생성이 농도 의존적으로 감소하는 결과를 얻을 수 있었다. DPPH 법, ABTS ORAC...
Abstract In this study, we investigated the effects and molecular mechanisms of 2‐phenylbenzimidazole‐5‐sulphonic acid (PBSA), an ultraviolet B protecting agent used in sunscreen lotions moisturizers, on ovarian cancer cell responses tumour angiogenesis. PBSA treatment markedly blocked mitogen‐induced invasion through down‐regulation matrix metalloproteinase (MMP) expression activity SKOV‐3 cells. addition, inhibited proliferation by suppression cyclin‐dependent kinases (Cdks), but not...