A5101698176- Ginger and Zingiberaceae research
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Phytochemical Studies and Bioactivities
- Bioactive natural compounds
- Phytochemistry and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Medicinal Plants
- melanin and skin pigmentation
- Immune Response and Inflammation
- Sirtuins and Resveratrol in Medicine
- Ginseng Biological Effects and Applications
- Sesquiterpenes and Asteraceae Studies
- Biological Stains and Phytochemicals
- Biochemical Analysis and Sensing Techniques
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Phytochemical compounds biological activities
- Skin Protection and Aging
- Angiogenesis and VEGF in Cancer
- Healthcare and Venom Research
Bio-Medical Science (South Korea)
2017-2024
Gyeonggi College of Science and Technology
2015-2018
Gwangju University
2018
Gyeonggi Research Institute
2012-2015
Dankook University
2014-2015
Korea University
2010-2012
Kyung Hee University
2012
Kummerowia striata (K. striata) is used as a traditional medicine for inflammation-related therapy. To determine whether it has beneficial anti-melanogenic and anti-oxidant activities, we investigated the biological activities of ethanol extract (EKS) using variety in vitro cell culture model systems. The activity was assessed B16F10 melanoma cells terms melanin synthesis tyrosinase inhibitory activity. assays were performed 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2ʹ-azino-bis...
Increased beta-amyloid (Aβ) production and its aggregation to the oligomeric state is considered be a major cause of Alzheimer's disease (AD). Therefore, reducing Aβ-induced neurotoxicity could provide suitable means prevention or intervention in course AD. The neuroprotective effects isolates from Callistemon lanceolatus DC. (Myrtaceae) against Aβ were evaluated using PC12 cells. To evaluate on apoptotic cell death Bcl-2 family proteins caspase-3, TUNEL assays Western blotting performed,...
Abstract Inflammation is involved in various diseases, including chronic inflammatory disease and arthritis. The inflammation induced by the production of cyclooxygenease (COX)-2 inducible nitric oxide synthase (iNOS), which are important mediators inflammation. In this study, we investigated ethanol extract Tribulus terrestris (ETT) inhibited expression COX-2 iNOS lipopolysaccharide(LPS)- stimulated RAW264.7 cells. We observed that ETT significantly decreased release NO a dose-dependent...
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin its intracellular signaling mechanisms have not yet been identified. Results our study showed that decreased cell proliferation increased apoptosis, causing DNA fragmentation, depolarization mitochondrial membrane, generation reactive oxygen species, an increase lipid peroxidation in ovarian cancer cells...
Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim this study was to investigate effect an ethanol extract (EAT) on obesity and hyperlipidemia C57BL/6 mice fed high-carbohydrate diet (HCD). First, were divided into five groups (n = 6/group) as follows: normal diet, HCD, HCD+EAT (100, 200, 400 mg/kg/day), which orally administered with EAT daily 84 days. Using...
Chronic oral inflammation and biofilm-mediated infections drive diseases such as dental caries periodontitis. This study investigated the anti-inflammatory antibacterial potential of an ethanol extract from Astilbe chinensis inflorescence (GA-13-6) a prominent candidate for natural complex substances (NCS) with therapeutic potential. In LPS-stimulated RAW 264.7 macrophages, GA-13-6 significantly suppressed proinflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor...
Smilax sieboldii, a climbing tree belonging to Smilacaceae, has been used in traditional oriental medicine for treating arthritis, tumors, leprosy, psoriasis, and lumbago. To evaluate the anti-obesity effects of S. sieboldii (Smilacaceae), we screened methylene chloride (CH2Cl2), ethyl acetate (EtOAc), aqueous-saturated n-butanol, ethanol (EtOH) extracts whole plant at various concentrations inhibit adipogenesis adipocytes. The 3T3-L1 cell line with Oil red O staining help fluorometry was as...
A new oligostilbene, caragasinin C (1), and seven known compounds, betulinic acid (2), 4-hydroxybenzaldehyde (3), (‒)-medicarpin (4), wistin (5), (2E,4S)-4-hydroxy-2-nonenoic (6), pallidol (7), (+)-α-viniferin (8), were isolated from the roots of Caragana sinica. The structure was established on basis spectroscopic techniques, including HRESIMS, 1D 2D-NMR.
In our search for novel plant-derived inhibitors of nitric oxide (NO) with potential treating inflammatory diseases, the phytochemicals Amomum tsao-ko fruits were investigated, leading to isolation one bicyclic nonane (1), three menthene skeleton monoterpenoids (2–4), and two acyclic (5 6). Their structures identified using one- two-dimensional nuclear magnetic resonance spectroscopy, mass spectrometry. To best knowledge, compounds 2–5 obtained from genus first time. All isolates tested...
In the course of screening for cosmetic ingredients by measuring antioxidant and antiwrinkle whitening anti-inflammatory activities, skin-related activity was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 2,2 <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:msup> <a:mrow/> <a:mrow> <a:mo>′</a:mo> </a:mrow> </a:msup> </a:math> -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) elastase inhibition, tyrosinase nitric oxide assay. Several...
Abstract Amomum tsao-ko (Zingiberaceae), an important traditional medicinal herb, possesses many biological activities, including anti-inflammatory effects. Though the anti-obesity properties of crude ethanol extract A. fruits have been reported, anti-adipogenic its phytochemical constituents not reported. Therefore, in present study, we isolated active and investigated their The bioassay-guided isolation phytochemicals from identified four bioactive compounds, comprising one fatty acid ( 1...
Two new compounds, including a nor-pimarane diterpenoid (continentanol, 1) and phenolic derivative (aralianic acid, 2), along with the known diterpenoids (3–11), polyacetylenes (12–15), components (16–28), phytosterols (29 30), were isolated from roots of Aralia continentalis. The structures compounds established by spectroscopic data interpretation, particularly HRESIMS, 1 D 2 NMR HSQC HMBC. Also, those identified spectral comparison reported values.
Amomum tsao-ko used as a traditional oriental herbal medicine, is indigenous to several Asia countries. In this study, we investigated anti-obesity activity of the ethanol extract Taso-ko (A. tsao-ko). The A. inhibited adipocyte differentiation using Oil Red O assay in 3T3-L1 cells. Inhibitory effect on adipogenesis was modulated by down-regulation adipogenic transcriptional factor such peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα) and...
Tribulus terrestris L. (Zygophyllaceae) is an annual plant widely distributed in warm temperate and tropical regions of southern Asia, Africa, parts Eastern Europe, Australia. The fruits T. have a long history use traditional Chinese medicines for the treatment high blood pressure, eye problems, edema, abdominal distention, sexual dysfunction veiling. 1,6 This also used as aphrodisiac, diuretic nervine Ayurveda, Unani, another system Indian medicine. 2 Preparation containing steroidal...
In the present study, we demonstrate regulatory effects and mechanism of broussonin A B, diphenylpropane derivatives isolated from Broussonetia kazinoki, on vascular endothelial growth factor-A (VEGF-A)-stimulated cell responses in vitro microvessel sprouting ex vivo. Treatment with or B suppressed VEGF-A-stimulated proliferation by regulating expression cycle-related proteins phosphorylation status retinoblastoma protein. addition, treatment abrogated angiogenic including migration,...