A5016855299- Xenotransplantation and immune response
- Cardiac Imaging and Diagnostics
- HIV-related health complications and treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Lipoproteins and Cardiovascular Health
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Infective Endocarditis Diagnosis and Management
- Venous Thromboembolism Diagnosis and Management
- Aortic Thrombus and Embolism
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Hepatitis C virus research
- Cardiac Valve Diseases and Treatments
- HIV, Drug Use, Sexual Risk
- Otolaryngology and Infectious Diseases
- Metabolism and Genetic Disorders
University of Maryland, Baltimore
2021-2024
Providence VA Medical Center
2022-2024
Barnes-Jewish Hospital
2024
Brown University
2019-2022
Lifespan
2022
Rhode Island Hospital
2019-2021
Providence College
2020
Background: While an association between atherosclerosis and dementia has been identified, few studies have assessed the longitudinal relationship aortic valve calcification (AVC) cognitive impairment (CI). Objective: We sought to determine whether AVC derived from lung cancer screening CT (LCSCT) was associated with CI in a moderate-to-high atherosclerotic risk cohort. Methods: This single site, retrospective analysis of 1401 U.S. veterans (65 years [IQI: 61, 68] years; 97%male) who...
Coomprhensive data on temporal trends in cardiovascular disease (CVD) risk factors and outcomes people living with HIV are limited. Using retrospective 50,284 US Veterans (VLWH) who received care the VA from 2001 to 2019, we calculated prevalence incidence estimates of CVD outcomes, as well average annual percent changes (AAPC) estimates. The mean age increased 47.8 (9.1) years 58.0 (12.4) during study period. population remained predominantly (>95%) male majority Black (∼50%). progressively...
Description of Case: A 56-year-old male with ischemic cardiomyopathy, HeartMate 3 LVAD implantation presented fatigue and diarrhea after eating expired cheese a week prior. Hypovolemia, AKI, an unremarkable interrogation INR 3.4 were noted. Blood cultures infectious work-up including imaging obtained. Imaging was unremarkable. Over the first 2 hospital days, he fluid resuscitated. Hemodynamics showed low biventricular filling pressures adequate cardiac index. On day 3, blood revealed...
Background: Our institution performed two transgenic porcine to human cardiac xenotransplantations. There is limited data with the first xenograft suggesting echocardiographic assessment of in humans correlates invasive hemodynamic assessments. We investigated whether echocardiographic-derived indices would correlate measurements both xenotransplants. Methods: Serial transthoracic echocardiography (TTE) and right heart catheterizations (RHC) were xenografts. Retrospective analysis TTE...
Introduction: Left ventricular assist devices (LVADs) are a therapy for the management of end stage heart failure. LVADs typically managed with long-term therapeutic anticoagulation warfarin to prevent thrombotic complications. Direct oral anticoagulants (DOACs) easier manage than other medical conditions requiring anticoagulation. There is limited data regarding DOAC safety in patients LVADs. Hypothesis: no significant difference outcomes LVAD when on compared warfarin. Methods: In single...
Introduction: Pregnancy in patients with advanced heart failure requiring left ventricular assist device (LVAD) support is risky and discouraged, though there are cases of successful deliveries. Hypothesis: A 29-year-old G3P2002 female history embolic cerebrovascular accident, postpartum hemorrhage, peripartum cardiomyopathy status-post HeartMate 3 (HM3) LVAD, became pregnant after intrauterine dislodgement. She elected to continue the pregnancy against advice maternal-fetal medicine (MFM)....
Introduction: Our institution performed the first genetically modified porcine to human cardiac xenotransplantation in a 57-year-old male. The patient survived 60 days post-transplant. (1) We sought identify whether left ventricular global longitudinal strain (LV-GLS) correlates with invasive hemodynamics this novel clinical scenario. In advanced heart failure patients, ejection fraction may not provide enough information as overall function of ventricle. Alternative measures such GLS and...
Background: Our institution performed the first genetically modified porcine cardiac xenotransplantation in a human. Due to limited data on monitoring xenografts, our laboratory conducted longitudinal noninvasive imaging for surveillance and clinical evaluation. Methods: We weekly transthoracic echocardiograms (TTE) with global strain (GLS) over 2 months endomyocardial biopsy (EMBx) correlation. Results: LV ejection fraction (LVEF) remained normal or hyperdynamic throughout patient’s course....
Introduction: Our center performed the first cardiac xenotransplant of a genetically modified porcine heart into human. We sought to identify whether left ventricular global longitudinal strain (LV-GLS) correlates with invasive hemodynamics in this novel clinical scenario. Methods: Transthoracic echo (TTE) and without contrast right catheterization were after xenotransplantation. Retrospective analyses TTE hemodynamic data assess correlation between various parameters. The following...