A5071178138- Vascular Tumors and Angiosarcomas
- Acute Myeloid Leukemia Research
- Renal and related cancers
- Hippo pathway signaling and YAP/TAZ
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Hemoglobin structure and function
- Plant Genetic and Mutation Studies
- Plant nutrient uptake and metabolism
- Sarcoma Diagnosis and Treatment
- Plant Physiology and Cultivation Studies
- Neurofibromatosis and Schwannoma Cases
- Plant Pathogens and Resistance
- Pineapple and bromelain studies
- Advances in Cucurbitaceae Research
- Chronic Myeloid Leukemia Treatments
- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Gastrointestinal Tumor Research and Treatment
- Banana Cultivation and Research
- Multiple Myeloma Research and Treatments
Cleveland Clinic
2021-2024
University of Washington
2005
Institute of Genetics and Developmental Biology
2003-2004
Chinese Academy of Sciences
2003-2004
Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma caused by the WWTR1(TAZ)-CAMTA1 (TC) gene fusion. This fusion has been observed in almost all reported EHE cases and functions as constitutively activated TAZ. Sequencing of human tumors has, however, identified additional secondary mutations approximately 50% EHE, most commonly loss tumor suppressor CDKN2A. In this study, effect CDKN2A tumorigenesis was evaluated.Mice bearing conditional TC allele were paired with Cdkn2a knockout...
Both the oxygen diffusion rate and solubility vary with depth into interior of biological membranes. The product these two gradients generates a single gradient, permeability which is smooth continuous function distance from center membrane. Using electron paramagnetic resonance spin-probe method, relaxation gradient oxygen, directly proportional to quantity that can be measured in membranes under physiological conditions. obtained provides calibrated ruler for determining membrane residues...
There are no effective treatment options for patients with aggressive epithelioid hemangioendothelioma (EHE) driven by the TAZ-CAMTA1 (TC) fusion gene. Here, we aimed to understand regulation of TC using pharmacologic tools and identify vulnerabilities that can potentially be exploited EHE.
Amplified fragment length polymorphism (AFLP) analyses were used to assess genetic diversity among 30 genotypes of watermelon [ Citrullus lanatus (Thunb.) Mansf.] representing a broad base, including breeding lines and commercial germplasm. Eight AFLP primer combinations selected from 64 polymophic. The was 13.0% 31.9% within the 28 cultivars examined, 45.3% 64.2% all genotypes. Each genotype could be successfully distinguished based on scoring. Cluster grouping accessions analysis...
Activating mutations in KIT/PDGFRA receptor tyrosine kinases drive gastrointestinal stromal tumors (GIST). inhibitors, such as imatinib do not evoke an effective cytocidal response, leaving room for quiescence and development of multiple secondary resistance mutations. As the majority clones activate PI3K MAPK pathways, we investigated whether combined targeting KIT/PI3K/MAPK (KPM) pathways overcomes drug GIST cells. We monitored proliferation imatinib–sensitive and–resistant cell lines...
<div>AbstractPurpose:<p>There are no effective treatment options for patients with aggressive epithelioid hemangioendothelioma (EHE) driven by the <i>TAZ–CAMTA1</i> (<i>TC</i>) fusion gene. Here, we aimed to understand regulation of TC using pharmacologic tools and identify vulnerabilities that can potentially be exploited EHE.</p>Experimental Design:<p>TC is a transcriptional coregulator; hypothesized compounds reduce nuclear levels, either...
<p>Figure S1. Dose-response curves of triptonide, triptolide, and dBET6</p>
<p>Figure S2. Localization of TC following Dina + MG132 treatment</p>
<p>Figure S2. Localization of TC following Dina + MG132 treatment</p>
<p>Figure S1. Dose-response curves of triptonide, triptolide, and dBET6</p>
<div>AbstractPurpose:<p>There are no effective treatment options for patients with aggressive epithelioid hemangioendothelioma (EHE) driven by the <i>TAZ–CAMTA1</i> (<i>TC</i>) fusion gene. Here, we aimed to understand regulation of TC using pharmacologic tools and identify vulnerabilities that can potentially be exploited EHE.</p>Experimental Design:<p>TC is a transcriptional coregulator; hypothesized compounds reduce nuclear levels, either...
<div>AbstractPurpose:<p>Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma caused by the <i>WWTR1(TAZ)</i>–<i>CAMTA1</i> (TC) gene fusion. This fusion has been observed in almost all reported EHE cases and functions as constitutively activated TAZ. Sequencing of human tumors has, however, identified additional secondary mutations approximately 50% EHE, most commonly loss tumor suppressor <i>CDKN2A</i>. In this study, effect...
<p>Gross and microscopic pathology of lymphoma samples</p>
<p>Ki67 staining and single-cell RNA sequencing</p>
<p>Immunohistochemistry of EHE allograft tumors</p>
<p>Validation of the EHE cell lines</p>
<p>Ki67 staining and single-cell RNA sequencing</p>