A5061687259- Physiological and biochemical adaptations
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Aortic Disease and Treatment Approaches
- Endoplasmic Reticulum Stress and Disease
- Bat Biology and Ecology Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Neural dynamics and brain function
- Connective tissue disorders research
- Pacific and Southeast Asian Studies
- ATP Synthase and ATPases Research
- Hormonal Regulation and Hypertension
- Exercise and Physiological Responses
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Adrenal and Paraganglionic Tumors
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- Forensic Anthropology and Bioarchaeology Studies
- Diabetes Treatment and Management
- Pancreatic function and diabetes
Boston University
2018-2023
University of California, Davis
2017
Yale University
2014-2015
Cellular Research (United States)
2015
United States Department of Veterans Affairs
1996
University of Miami
1996
Significance Like vision, audition, and olfaction, mechanosensation is a fundamental way in which animals interact with the environment, but it remains least well understood at cellular molecular levels. Here, we explored evolutionary changes that contribute to enhancement of mechanosensitivity tactile-foraging ducks. We found somatosensory neurons innervate duck bill can detect physical force much more efficiently than analogous cells other species, such as mice. Furthermore, ducks exhibit...
Hibernating mammals possess a unique ability to reduce their body temperature ambient levels, which can be as low -2.9 °C, by active down-regulation of metabolism. Despite such depressed physiologic phenotype, hibernators still maintain activity in nervous systems, evidenced continued sensitivity auditory, tactile, and thermal stimulation. The molecular mechanisms that underlie this adaptation remain unknown. We report, using differential transcriptomics alongside immunohistologic...
Background: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic (SR) has been shown to play a critical role in mediating mitochondrial dysfunction response reactive oxygen species, we hypothesized that oxidation C674 would modulate the effects of species on and mitochondria-dependent apoptosis cardiac myocytes. Methods: Adult rat ventricular myocytes expressing wild-type SERCA2b or...
Thoracic aortic aneurysms (TAAs) are abnormal dilatations and a major cardiovascular complication of Marfan syndrome. We previously demonstrated critical role for vascular smooth muscle (VSM) SirT1 (sirtuin-1), lysine deacetylase, against maladaptive remodeling associated with chronic oxidative stress aberrant activation MMPs (matrix metalloproteinases).
Rationale: BCL11B (B-cell leukemia 11b) is a transcription factor known as an essential regulator of T lymphocytes and neuronal development during embryogenesis. A genome-wide association study showed that gene desert region downstream , to function enhancer, harbors single nucleotide polymorphisms associated with increased arterial stiffness. However, role for in the adult cardiovascular system unknown. Objective: Based on these human findings, we sought examine relation between function....
The chance discovery of a 1.5–3.5 years old mummified girl presents unique opportunity to further our understanding health and disease among children in 19th Century San Francisco. This study focuses on carbon nitrogen stable isotope signatures serial samples hair that cover the last 14 months her life. Results suggest an initial omnivorous diet with little input from marine resources or C4 plants. Around six before death δ15N starts steady increase, noticeable acceleration just two she...
Background Persistent activation of endoplasmic reticulum stress and the unfolded protein response (UPR) induces vascular cell apoptosis, contributing to atherogenesis. Aging hypercholesterolemia are 2 independent proatherogenic factors. How they affect UPR signaling remains unclear. Methods Results Transcriptome analysis aortic tissues from high fat diet–fed aged ApoE −/− mice revealed 50 overlapping genes enriched for stress‐ UPR‐related pathways. Aortae control, Western diet (WD)–fed,...
Adrenal cortical mitochondria display an extensive capacity to adapt morphologically the functional state of adrenal cell. In present study, we have used transmission electron microscopy analyze tissues from 3 normal human glands (zona fasciculata and zona glomerulosa), 8 steroid-secreting adenomas (3 cortisol-producing, 4 aldosterone-producing, 1 progesterone-producing tumor), correlating both clinical biochemical features with cellular ultrastructure. The morphology was related enzyme...
Background: Thoracic aortic aneurysms and dissections (TAAD) are life-threatening conditions a major cardiovascular complication of Marfan syndrome (MFS). We previously demonstrated that vascular smooth muscle sirtuin-1 (Sirt1), lysine deacetylase, protects against dissection by suppressing aberrant activation matrix metalloproteinases (MMP2/9). Objective: In this study, we investigated whether Sirt1’s dysregulation contributed to TAAD in MFS. Approach & Results: Our results showed...
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent diabetes. While animal studies suggest SGLT2i cardiac metabolism, the effect on mitochondrial function is not known. Our goal was to assess effects function, high energy phosphates and genes encoding proteins hearts mice with without diet-induced Methods & Results: Ertugliflozin (Ertu; 0.5 mg/g) given for 4 months fed a fat, sucrose (HFHS) diet that causes...