A5103281878- Redox biology and oxidative stress
- Liver physiology and pathology
- Renal and related cancers
- Angiogenesis and VEGF in Cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Sulfur Compounds in Biology
- Liver Disease and Transplantation
- Virus-based gene therapy research
- Liver Disease Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Aortic Disease and Treatment Approaches
- RNA Interference and Gene Delivery
- bioluminescence and chemiluminescence research
- Cardiac Valve Diseases and Treatments
- Restraint-Related Deaths
- Cancer, Hypoxia, and Metabolism
- Intracranial Aneurysms: Treatment and Complications
- Connective tissue disorders research
- Cardiovascular Disease and Adiposity
- Adenosine and Purinergic Signaling
- Child Abuse and Related Trauma
- Nitric Oxide and Endothelin Effects
- Pluripotent Stem Cells Research
Boston University
2017-2023
Fukuda Denshi (Japan)
2021
University of Yamanashi
2019
University of Vermont
2019
University of Dundee
2019
University of Virginia
2019
University School
2017
The University of Tokyo
2009-2016
RIKEN
1998
Hepatic oval cells are considered to be facultative hepatic stem cells(HSCs) that differentiate into hepatocytes and cholangiocytes in severely injured liver. have also been implicated tumorigenesis. However, their nature origin remain elusive. To isolate characterize mouse cells, we searched for cell surface molecules expressed on analyzed at the single-cell level by flow cytometric analysis vitro colony formation assay. We demonstrate epithelial adhesion molecule (EpCAM) is both normal...
Delivering and expressing a gene of interest in cells or living animals has become pivotal technique biomedical research therapy. Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe demonstrate high transfer efficiency, low immunogenicity, stable long-term expression, selective tissue tropism. Combined with modern technologies, such as cell-specific promoters, the Cre/lox system, genome editing, AAVs represent practical, rapid, economical alternative to...
Cardiac progenitor cells (CPCs) are a crucial source of in cardiac development and regeneration. However, reported CPCs heterogeneous, no gene has been identified to transiently mark undifferentiated throughout heart development. Here we show that Spalt-like 1 (Sall1), zing-finger transcription factor, is expressed giving rise both left right ventricles. Sall1 was precardiac mesoderm contributing the first field (left ventricle precursors) but not itself. Similarly, expression maintained...
TROP2, a cell surface protein structurally related to EpCAM, is expressed in various carcinomas, though its function remains largely unknown. We examined the expression of TROP2 and EpCAM fetal mouse tissues, found distinct patterns ureteric bud kidney, which forms tree-like structure. The tip cells proliferate form branches, whereas trunk differentiate polarized ductal was throughout bud, strongest at but diminished towards tips, indicating populations bud. highly expressing (TROP2high)...
Interleukin (IL)-33 is an interleukin-1 like cytokine that enhances Th2 responses and mediates mucosal immunity allergic inflammation but the mechanism regulating endogenous IL-33 production are still under investigation. In macrophages, lipopolysaccharide (LPS) administration resulted in marked induction of mRNA was blunted macrophages from glutaredoxin-1 (Glrx) knockout mice RAW264.7 with Glrx knockdown by siRNA. Glutaredoxin-1 a small cytosolic thioltransferase controls reversible protein...
Thoracic aortic aneurysms (TAAs) are abnormal dilatations and a major cardiovascular complication of Marfan syndrome. We previously demonstrated critical role for vascular smooth muscle (VSM) SirT1 (sirtuin-1), lysine deacetylase, against maladaptive remodeling associated with chronic oxidative stress aberrant activation MMPs (matrix metalloproteinases).
Liver fibrosis is a sign of non-alcoholic fatty liver disease progression towards steatohepatitis (NASH) and cirrhosis accelerated by aging. Glutaredoxin-1 (Glrx) controls redox signaling reversing protein S-glutathionylation, induced oxidative stress, its deletion causes in mice. Although Glrx regulates various pathways, including metabolism apoptosis, the impact on has not been studied. Therefore, we evaluated role aging or high-fat, high-fructose diet. We found that: (1) upregulation...
Glutaredoxin-1 (Glrx) is a small cytosolic enzyme that removes
A 24-year-old man with a history of bloody sputum for 6 months was referred to our hospital suspected alveolar hemorrhaging due vasculitis. Chest computed tomography showed ground-glass opacities in both lungs, and an examination his bronchoalveolar lavage fluid hemorrhaging. However, no evidence vasculitis found, subsequent polysomnographic testing confirmed that he had severe obstructive sleep apnea (OSA). Since the improved after initiation continuous positive airway pressure treatment,...
A brief account is given of the anatomy and fibre-optic-like light-guiding properties rod-like elements in eye photophores on ventral surface eyeball Japanese firefly squid Watasenia scintillans. These form a dominant proportion volume photophore (which assumed to function counter-illumination) are aligned such that light from bioluminescent core directed cone downwards eye. coplanar arrangement lamellae light-guides strongly suggests passing through will be narrowly restricted both...
Background: Thoracic aortic aneurysms and dissections (TAAD) are life-threatening conditions a major cardiovascular complication of Marfan syndrome (MFS). We previously demonstrated that vascular smooth muscle sirtuin-1 (Sirt1), lysine deacetylase, protects against dissection by suppressing aberrant activation matrix metalloproteinases (MMP2/9). Objective: In this study, we investigated whether Sirt1’s dysregulation contributed to TAAD in MFS. Approach & Results: Our results showed...
Background: Endothelial dysfunction is a common mediator of aneurysmal remodeling regardless etiology and the vascular bed that occur (e.g., genetic mutations, hypertension, aging, smoking, abdominal or thoracic artery aortic root), but underlying mechanisms remain unknown. This work aims to test hypothesis perturbing thiol redox signaling in endothelial cells triggers aberrant activation matrix metalloproteinase-2 -9, thereby precipitating remodeling. Methods Results: In human aneurysm (AA)...