A5036570732- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Hypothalamic control of reproductive hormones
- Biochemical effects in animals
- Menstrual Health and Disorders
- Sex and Gender in Healthcare
- Tryptophan and brain disorders
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Zebrafish Biomedical Research Applications
- Acute Myeloid Leukemia Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Family Support in Illness
- Erythrocyte Function and Pathophysiology
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Hormonal Regulation and Hypertension
- Menopause: Health Impacts and Treatments
- Gut microbiota and health
- Healthcare and Venom Research
National Institute of Mental Health
2021-2023
National Institute on Alcohol Abuse and Alcoholism
2022-2023
Behavioral Pharma (United States)
2023
University of Rochester Medical Center
2020-2021
University of Rochester
2020-2021
University of Maryland, Baltimore
2015-2019
National Institutes of Health
2018
Previous research demonstrates that Slc6a15, a neutral amino acid transporter, is associated with depression susceptibility. However, no study examined Slc6a15 in the ventral striatum [nucleus accumbens (NAc)] depression. Given our previous characterization of as striatal dopamine receptor 2 (D2)-neuron-enriched gene, we role NAc D2-neurons mediating susceptibility to stress male mice. First, showed <i>Slc6a15</i> mRNA was reduced mice susceptible chronic social defeat (CSDS), paradigm...
Hematopoietic ontogeny consists of two broad programs: an initial hematopoietic stem cell (HSC)-independent program followed by HSC-dependent hematopoiesis that sequentially seed the fetal liver and generate blood cells. However, transition from HSC-independent to HSC-derived remains poorly characterized. To help resolve this question, we developed Mds1CreERT2 mice, which inducibly express Cre-recombinase in emerging HSCs aorta label long-term adult HSCs, but not yolk-sac-derived primitive...
Premenstrual Dysphoric Disorder (PMDD) is characterized by debilitating mood symptoms in the luteal phase of menstrual cycle. Prior studies affected women have implicated a differential response to ovarian steroids. However, molecular basis these patients' hormone remains poorly understood. We performed transcriptomic analyses lymphoblastoid cell lines (LCLs) derived from with PMDD and asymptomatic controls cultured under untreated (steroid-free), estradiol-treated (E2), progesterone-treated...
Methamphetamine (METH) is a psychomotor stimulant that reported to enhance sexual desire and behavior in both men women, leading increases unplanned pregnancies, sexually-transmitted infections, even comorbid psychiatric conditions. Here, we discuss our rodent model of enhanced motivation which the co-administration METH ovarian hormones, estradiol progesterone, intensify incentive properties stimulus measures sexually-motivated presence an androgen-specific cue. We then present...
Brexanolone, a formulation of the neurosteroid allopregnanolone (ALLO), is approved for treating postpartum depression (PPD) and being investigated therapeutic efficacy across numerous neuropsychiatric disorders. Given ALLO’s beneficial effects on mood in women with PPD compared to healthy control women, we sought characterize compare cellular response ALLO (n = 9) or without 10, i.e., Controls) past PPD, utilizing our previously established patient-derived lymphoblastoid cell lines (LCLs)....
Methamphetamine, a psychostimulant drug of abuse, increases sexual motivation both in humans and rodent models. The activation dopamine type-1 receptors (D1Rs) within the medial amygdala, presence ovarian hormones (EB+P), are necessary sufficient for proceptive, or sexually motivated, behaviors. Here, we demonstrate that methamphetamine progesterone receptor expression amygdala independently D1R activation, lentiviral overexpression was able to recapitulate methamphetamine-induced...
The risk of depression increases 2-3 fold for women during the menopause transition compared to premenopausal women. Additionally, peri/postmenopausal with even minor are at an increased cardiovascular mortality (Wassertheil-Smoller et al, 2004). Clinical studies show both therapeutic benefits estradiol (E2) in perimenopausal (PMD) (Schmidt 2000, Soares 2001) and symptom-provoking effects E2-withdrawal (E2-WD) past PMD, which not experienced by those without PMD 2015). It has been suggested...
Hematopoietic ontogeny consists of two broad programs: an initial hematopoietic stem cell (HSC)-independent program arising from the yolk sac followed by HSC-dependent hematopoiesis intra-embryonic arteries. While HSC-independent erythro-myeloid (EMP) progenitors and rare lymphoid progenitors, as well HSCs, sequentially seed fetal liver generate blood cells, transition to HSC-derived remains poorly characterized. To help resolve this question, we developed Mds1CreER mice, which inducibly...