A5066167179- Bacterial Genetics and Biotechnology
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Genomics and Rare Diseases
- Single-cell and spatial transcriptomics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Proteoglycans and glycosaminoglycans research
- Antibiotic Resistance in Bacteria
- Erythrocyte Function and Pathophysiology
- Enterobacteriaceae and Cronobacter Research
- Biomedical Text Mining and Ontologies
- Glycosylation and Glycoproteins Research
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Evolution and Genetic Dynamics
University of Guelph
2020-2025
University of Toronto
2024
Infections caused by Klebsiella pneumoniae continue to be a global public health threat; the treatment of these infections is complicated high frequency multidrug resistance. K. produces polysaccharide capsule required for virulence. Hypervirulent isolates also have hypermucoviscous (HMV) phenotype that increases virulence, and we recently demonstrated horizontally acquired gene, rmpD , HMV hypervirulence but identity polymeric product(s) in uncertain.
The enterobacterial common antigen (ECA) is conserved in Gram-negative bacteria of the Enterobacterales order although its function debated. ECA biogenesis depends on Wzx/Wzy-dependent strategy whereby newly synthesized lipid-linked repeat units, lipid III, are transferred across inner membrane by III flippase WzxE. WzxE part Wzx family and required many glycan assembly systems, but an understanding molecular mechanism hindered due to a lack structural evidence. Here, we present first X-ray...