Abstract Control on spatial location and density of defects in two-dimensional materials can be achieved using electron beam irradiation. Conversely, ultralow accelerating voltages ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"><mml:mrow><mml:mo>⩽</mml:mo></mml:mrow></mml:math> 5 kV) are used to measure surface morphology, with no expected defect creation. We find clear signatures creation monolayer MoS 2 at these voltages. Evolution...

Metastatic cancers account for up to 90% of cancer-related deaths. The clear differentiation metastatic from primary is crucial cancer type identification and developing targeted treatment each type. DNA methylation patterns are suggested be an intriguing target prediction also considered important mediator the transition cancer. In present study, we used 24 types 9303 methylome samples downloaded publicly available data repositories, including Cancer Genome Atlas (TCGA) Gene Expression...

Abstract World Health Organization (WHO) declared COVID-19 as a pandemic disease on March 11, 2020. Comparison of genome sequences from diverse locations allows us to identify the genetic diversity among viruses which would help in ascertaining viral virulence, pathogenicity, origin and spread SARS-CoV-2 between countries. The aim this study is ascertain Indian isolates. Initial examination phylogenetic data genomes (n=3123) different continents deposited at GISAID (Global Initiative Sharing...

The electronic strong coupling (ESC) of a molecular transition with cavity modes can result in modified excited state photophysics compared to its uncoupled counterparts. Often, such changes are attributed kinetics effects, overlooking the possible modifications ground-state intermolecular interactions. spin-coated films Chlorin e6 trimethyl ester (Ce6T) provide platform for studying role ESC dictating and preorganization Ce6T molecules thin facilitates excitonic interaction, leading an...

Trapped materials at the interfaces of two-dimensional heterostructures (HS) lead to reduced coupling between layers, resulting in degraded optoelectronic performance and device variability.Further, nanobubbles can form interface during transfer or after annealing.The question what is inside a nanobubble, i.e. trapped material, remains unanswered, limiting studies applications these nanobubble systems.In this work, we report two key advances.Firstly, quantify quality using RAW-format optical...

Cancer stem cells (CSCs) alone can initiate and maintain tumors, but the function of non-cancer (non-CSCs) that form tumor bulk remains poorly understood. Proteomic analysis showed a higher abundance extracellular matrix small leucine-rich proteoglycan fibromodulin (FMOD) in conditioned medium differentiated glioma (DGCs), equivalent non-CSCs, compared to stem-like (GSCs). DGCs silenced for FMOD fail cooperate with co-implanted GSCs promote growth. downregulation neither affects GSC growth...

Optical contrast is the most common preliminary method to identify layer number of two-dimensional (2D) materials, but it seldom used as a confirmatory technique. We explain reason for variation optical between imaging systems, motivating system-independent measurement critical need. describe universal quantify using RGB (red-green-blue) and RAW images. For images, slope 2D flake (MoS2, WSe2, graphene) intensity vs substrate extracted from images with varying lamp power. The identifies...

World Health Organization (WHO) declared COVID-19 as a pandemic disease on 11 March 2020.Comparison of genome sequences from diverse locations allows us to identify the genetic diversity among viruses which would help in ascertaining viral virulence, pathogenicity, origin and spread SARS-CoV-2 between countries.The aim this study is determine Indian isolates.Initial examination phylogenetic data genomes (n = 3123) different continents deposited at GISAID (Global Initiative Sharing All...

The whole-genome sequence of an Indian field isolate classical swine fever virus, NIVEDI-165, was found to be subtype 1.1, and it showed 89 99% amino acid identity 84 nucleotide with four five virus (CSFV) isolates, respectively. To the best our knowledge, this is first report on a full-genome CSFV from South India.

Trapped materials at the interfaces of two-dimensional heterostructures (HS) lead to reduced coupling between layers, resulting in degraded optoelectronic performance and device variability. Further, nanobubbles can form interface during transfer or after annealing. The question what is inside a nanobubble, i.e. trapped material, remains unanswered, limiting studies applications these nanobubble systems. In this work, we report two key advances. Firstly, quantify quality using RAW-format...

In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, PITAR ( p 53 I nactivating T RIM28 ssociated R NA), as an inhibitor p53. is oncogenic Cancer/testis lncRNA and highly expressed in glioblastoma (GBM) glioma stem-like cells (GSC). We establish that TRIM28 mRNA, which encodes p53-specific E3 ubiquitin ligase, direct target PITAR. interaction RNA stabilized resulted increased protein levels reduced steady-state due to...

In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, PITAR ( p 53 I nactivating T RIM28 A ssociated R NA), as an inhibitor p53. is oncogenic Cancer/testis lncRNA and highly expressed in glioblastoma (GBM) glioma stem-like cells (GSC). We establish that TRIM28 mRNA, which encodes p53-specific E3 ubiquitin ligase, direct target PITAR. interaction RNA stabilized resulted increased protein levels reduced steady-state due to...

Neuromorphic computing has emphasized the need for memristors with non-volatile, multiple conductance levels. This paper demonstrates potential of hexagonal boron nitride (hBN)/graphene heterostructures to act as resistance states that can be optically tuned using visible light. The number levels in graphene controlled by modulating doping levels, achieved varying electric field strength or adjusting duration optical illumination. Our measurements show this photodoping results from...

In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here we have identified a long noncoding RNA, PITAR ( p 53 I nactivating T RIM28 ssociated R NA), as an inhibitor p53. is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We found that TRIM28 mRNA, which encodes p53-specific E3 ubiquitin ligase, direct target PITAR. interaction RNA stabilized resulted increased protein levels, enhanced ubiquitination, attenuated DNA damage response. While...

Abstract Cancer stem cells alone can initiate and maintain tumors, but the function of non-cancer that form tumor bulk remains poorly understood. Proteomic analysis showed a higher abundance extracellular matrix small leucine-rich proteoglycan Fibromodulin (FMOD) in conditioned medium (DGCs; differentiated glioma cells) compared to stem-like (GSCs). DGCs silenced for FMOD fail cooperate with co-implanted GSCs promote growth. downregulation neither affects GSC growth differentiation nor DGC...

Abstract Cancer stem-like cells (CSCs) and the differentiated bulk mainly contribute to cellular heterogeneity within a tumor. The dichotomous division pattern of CSCs sitting atop tumor hierarchy allow them self-renew, differentiate initiate repopulate aggressive tumors. These CSC-differentiation-derived reprogram states, accounting for high plasticity tumor; phenomenon governed by distinct epigenetic profiles two cell populations. Reciprocal signaling between its complex microenvironment...

In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, PITAR (p53 Inactivating TRIM28 Associated RNA), as an inhibitor p53. is oncogenic Cancer/testis lncRNA and highly expressed in glioblastoma (GBM) glioma stem-like cells (GSC). We establish that mRNA, which encodes p53-specific E3 ubiquitin ligase, direct target PITAR. interaction RNA stabilized resulted increased protein levels reduced steady-state due to enhanced...