A5089675944- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Stress Responses and Cortisol
- Systemic Lupus Erythematosus Research
- Estrogen and related hormone effects
- Tryptophan and brain disorders
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Neuropeptides and Animal Physiology
- Osteoarthritis Treatment and Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Receptor Mechanisms and Signaling
- Endometriosis Research and Treatment
- HER2/EGFR in Cancer Research
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Eicosanoids and Hypertension Pharmacology
- Cell Adhesion Molecules Research
- Adrenal Hormones and Disorders
- Peripheral Neuropathies and Disorders
- Inflammatory mediators and NSAID effects
- T-cell and B-cell Immunology
- Axon Guidance and Neuronal Signaling
- Hypothalamic control of reproductive hormones
TU Dortmund University
2017-2025
Leibniz Research Centre for Working Environment and Human Factors
2017-2025
University of Regensburg
2007-2016
Justus-Liebig-Universität Gießen
2016
Kerckhoff Klinik
2016
University Hospital Regensburg
2006-2014
Johns Hopkins Medicine
2013-2014
Johns Hopkins University
2013-2014
University of Genoa
2003-2011
Oxford University Hospitals NHS Trust
2010
<h3>Background:</h3> Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations. <h3>Aim and methods:</h3> In all layers of the colon, nerve fibre densities SP<sup>+</sup> fibres were investigated (22 Crohn's disease, six diverticulitis, 22 controls). addition, repellent factor semaphorin 3C (SEMA3C) was studied. The functional role nervous system tested dextran sodium sulfate (DSS)...
<h3>Background</h3> The proinflammatory and anti-inflammatory role of the sympathetic nervous system in early late inflammation is an unresolved paradox. A drastic loss nerve fibres synovial tissue patients with rheumatoid arthritis (RA) has previously been demonstrated. presence tyrosine hydroxylase (TH)-positive cells RA osteoarthritis (OA) determined, but these still unclear. <h3>Objective</h3> To characterise TH-positive inflamed OA to study their inflammation. <h3>Methods</h3> Synovial...
Sex hormones seem to modulate the immune/inflammatory responses by different mechanisms in female and male rheumatoid arthritis patients. The effects of 17beta-oestradiol testosterone were tested on cultured human monocytic/macrophage cell line (THP-1) activated with IFN-gamma order investigate their role proliferation apoptosis. Activated THP-1 cells presence (final concentration, 10 nM). evaluation markers included NF-kappaB DNA-binding assay, inhibition complex, proliferating nuclear...
Sex hormones play an active role in inflammatory responses, with androgens being anti‐inflammatory, whereas estrogens have both pro‐ and anti‐inflammatory effects. In rheumatoid arthritis (RA) patients, low levels of high estrone are found the synovial fluid. Aromatase is key enzyme for conversion into estrogens. Proinflammatory cytokines stimulate aromatase activity so that milieu can induce to Moreover, testosterone inhibits activity. As local androgen RA, this contribute synovium....
Polymyalgia rheumatica (PMR) may create some difficulties in the differential diagnosis of elderly-onset rheumatoid arthritis (EORA) and EORA with PMR-like onset (EORA/PMR).To investigate possible differences between three groups patients, regard to serum levels inflammatory cytokines steroidal hormones at baseline after 1 month treatment glucocorticoids (prednisone 7.5-12.5 mg/day).14 patients PMR, 15 14 EORA/PMR, as well healthy, matched controls were analysed. Tumour necrosis factor alpha...
Sensory nerve fibers transmit pain perception and secrete pro-inflammatory substance P (SP). Sympathetic anti-inflammatory norepinephrine endogenous opioids, which inhibit in a bidirectional crosstalk with sensory fibers. In patients anterior knee after primary arthroplasty of the (AKP), this study investigated parallel innervation infrapatellar fat pad by sympathetic A total 32 osteoarthritis (OA) (n = 10), AKP joint replacement 7), OA hip 15) were included. semiquantitatively detected...
The role of estrogens in rheumatoid arthritis (RA) is debated since both proinflammatory and antiinflammatory effects have been reported. Important evidence the dual conversion to various or metabolites. This study was undertaken examine downstream synovial cells from patients with RA osteoarthritis (OA).We studied serum levels estrone, estrone sulfate, sulfate membrane transporters, intracellular interconversion 17beta-estradiol, estrone/17beta-estradiol estrogen metabolites OA cells....
<h3>Objectives</h3> Studies in rheumatoid arthritis (RA), osteoarthritis (OA) and mice with demonstrated tyrosine hydroxylase-positive (TH<sup>+</sup>) cells arthritic synovium parallel loss of sympathetic nerve fibres. The exact function TH<sup>+</sup> mode TH induction are not known. <h3>Methods</h3> Synovial RA/OA were isolated cultured under normoxic/hypoxic conditions with/without stimulating enzyme cofactors inhibitors TH. We studied expression release cytokines/catecholamines. In vivo...
The sympathetic nervous system is proinflammatory in early collagen-induced arthritis (CIA) and antiinflammatory late disease. In arthritis, innervation of synovial lymphoid tissue markedly reduced. Thus, its suggested role difficult to explain. We hypothesized that newly discovered catecholamine-producing (catecholaminergic) cells are targets chemical sympathectomy. However, CIA, the time point appearance, location, possible elimination catecholaminergic have not been studied. purpose this...
Background Previous research revealed several biological and environmental factors modulating cognitive functioning over a human’s lifespan. However, the relationships interactions between (eg, genetic polymorphisms, immunological parameters, metabolic products, or infectious diseases) lifestyle, physical activity, nutrition, work type stress at work) as well their impact on functions across lifespan are still poorly understood with respect to complexity. Objective The goal of Dortmund Vital...
Abstract: Estrogens at physiological concentrations are thought to play an immune‐stimulating role, whereas androgens have anti‐inflammatory impact. However, their role on cytokine secretion in the presence or absence of cortisol has not been investigated. Furthermore, hydroxylated estrogens downstream 17β‐estradiol (E2) tumor necrosis factor (TNF) is known. In this study peripheral blood leukocytes healthy male subjects, we scrutinized influence prior sex hormones (for 24 h) with and...
Objective Observations in both animal models of arthritis and patients with rheumatoid (RA) suggest a role for dopamine its receptors RA. Because synovial fibroblasts (SFs) contribute to inflammation joint destruction RA, the aim this study was investigate dopaminergic pathways SFs obtained from RA and, comparison, osteoarthritis (OA) undergoing knee replacement surgery. Methods The expression all (D 1 –D 5 ) transporter assessed by immunofluorescence immunohistochemical staining. levels...
CpG ODN2006 is widely used as a potent B cell stimulant in vitro and vivo. However, it shows deficit targeting naïve cells vitro. In this study, we investigated whether α-IgM can support ODN2006-induced effects on to obtain enhanced activation with focus different subsets. Our results delineated robust activation, shown by increased marker expression cytokine secretion each agent alone, further augmented when combination. Interestingly, targeted mainly marginal zone-like cells, thus...
Sensory nerve fibres (NFs) contain two major neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP). The pro-inflammatory role of SP is known, while CGRP has anti-inflammatory activities by inhibiting T helper type 1 cytokines, TNF secretion leucocyte proliferation. We demonstrated the increase SP-positive NFs in RA as compared with OA. This study investigated density CGRP-positive relative to or sympathetic synovial tissue patients OA.By immunofluorescent staining 25 35...