A5027879258- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Analytical Chemistry and Sensors
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Near-Field Optical Microscopy
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
Taras Shevchenko National University of Kyiv
2021-2024
Photodynamic therapy (PDT) is a non-invasive anticancer treatment that uses special photosensitizer molecules (PS) to generate singlet oxygen and other reactive species (ROS) in tissue under excitation with red or infrared light. Though the method has been known for decades, it become more popular recently development of new efficient organic dyes LED light sources. Here we introduce ternary nanocomposite: water-soluble star-like polymer/gold nanoparticles (AuNP)/temoporfin PS, which can be...
Cancer chemotherapy faces two major challenges - high toxicity of active substances and tumor resistance to drugs. Low toxic nanocarriers in combination with anticancer agents can significantly increase the effectiveness therapy. Modern advances nanotechnology make it easy create materials necessary physical chemical properties.Two hybrid nanosystems dextran-polyacrylamide/ zinc oxide nanoparticles (D-PAA/ZnO NPs) were synthesized aqueous solution sulphate NPs (SO42-)) acetate (-OAc)). The...
A zinc tetraphenylporphyrin photosensitizer/dextran graft polyacrylamide anionic copolymer/Au nanoparticles (ZnTPP/D-g-PAAan/AuNPs) triple hybrid nanosystem was synthesized in water-based solution as a nanodrug for potential photodynamic therapy applications. Dynamic light scattering studies showed that the is stable against aggregation and sedimentation several days after preparation. The dependence of ZnTPP fluorescence intensity on gold concentration ZnTPP/D-g-PAAan/AuNPs has been...
The thermoresponsive Zinc TetraPhenylPorphyrin photosensitizer/Dextran poly (N-isopropylacrylamide) graft copolymer/Au Nanoparticles (ZnTPP/D-g-PNIPAM/AuNPs) triple hybrid nanosystem was synthesized in aqueous solution as a nanodrug for potential use thermally driven and controlled photodynamic therapy applications. of the has demonstrated excellent stability terms aggregation sedimentation several days after preparation. Optimal concentrations components providing lowest level highest...
A comparative study of in vitro anti-cancer photodynamic activities three-component zinc-tetraphenylporphyrin photosensitizer/dextran-graft-polyacrylamide copolymer/Au(Ag) nanoparticle (ZnTPP/D-g-PAA/Au(Ag)NP) nanohybrids on LNCaP prostate cancer cells was carried out under 420 nm light irradiation with low power. significant cytotoxic effect revealed for both ZnTPP/D-g-PAA/AgNP and ZnTPP/D-g-PAA/AuNP nanohybrids, where exhibited considerably higher anticancer activity (82%) compared to...