A5029541603- Neuroinflammation and Neurodegeneration Mechanisms
- Hydrogen's biological and therapeutic effects
- Inflammation biomarkers and pathways
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- Leptospirosis research and findings
- Macrophage Migration Inhibitory Factor
- Viral Infections and Vectors
- Alzheimer's disease research and treatments
- Hydrogen Storage and Materials
- Legume Nitrogen Fixing Symbiosis
- Plant nutrient uptake and metabolism
- Plant Micronutrient Interactions and Effects
- Neurological diseases and metabolism
- Peptidase Inhibition and Analysis
- Amyotrophic Lateral Sclerosis Research
- Mosquito-borne diseases and control
- Advances in Cucurbitaceae Research
- Prion Diseases and Protein Misfolding
- Cancer-related gene regulation
- Photosynthetic Processes and Mechanisms
- Vitamin C and Antioxidants Research
- Hepatitis Viruses Studies and Epidemiology
- Metalloenzymes and iron-sulfur proteins
Institute of Biomedical Technologies
2014-2016
National Research Council
2014-2016
National Academies of Sciences, Engineering, and Medicine
2016
University of Milan
2015
Istituto per le Tecnologie Didattiche
2015
University of Pavia
2015
European Institute of Oncology
2013
Protein methylation is a post-translational modification (PTM) by which variable number of methyl groups are transferred to lysine and arginine residues within proteins. Despite increased interest in this due its reversible nature emerging role diverse set biological pathways beyond chromatin, global identification protein has remained an unachieved goal. To characterise sites histones, we employed approach that combines heavy stable isotope labelling amino acids cell culture (hmSILAC) with...
Summary Molybdenum (Mo) and iron (Fe) are essential micronutrients required for crucial enzyme activities in plant metabolism. Here we investigated the existence of a mutual control Mo Fe homeostasis cucumber ( Cucumis sativus ). Plants were grown under single or combined starvation. Physiological parameters measured, ionomes tissues proteomes root mitochondria profiled, molybdo‐enzymes synthesis molybdenum cofactor (Moco) evaluated. found to affect each other's total uptake distribution...
Background Infectious Leptospira colonize the kidneys of reservoir (e.g. rats) and accidental hosts such as humans. The renal response to persistent leptospiral colonization, measured by urinary protein biosignatures, has not been systematically studied. Urinary exosomes--bioactive membrane-bound nanovesicles--contain cell-state specific cargo that additively reflect formation all along nephron. We hypothesized Leptospira-infection will alter content urine exosomes, further, these...
Nasu-Hakola disease (NHD) is a recessively inherited rare disorder characterized by combination of neuropsychiatric and bone symptoms which, while being unique to this disease, do not provide rationale for the unambiguous identification patients. These individuals, in fact, are likely go unrecognized either because they considered be affected other kinds dementia or fibrous dysplasia bone. Given that NHD has much common with Alzheimer's neurodegenerative disorders, it cannot expected achieve...
Nasu-Hakola Disease (NHD) is a recessively inherited systemic leukodystrophy disorder characterized by combination of frontotemporal presenile dementia and lytic bone lesions. NHD known to be genetically related structural defect TREM2 DAP12, two genes that encode for different subunits the membrane receptor signaling complex expressed microglia osteoclast cells. Because its rarity, molecular or proteomic studies on this are absent scarce, only case reports based neuropsychological genetic...