A5011864014- Viral Infections and Vectors
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Congenital Diaphragmatic Hernia Studies
- Antibiotic Use and Resistance
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Infective Endocarditis Diagnosis and Management
- Congenital Anomalies and Fetal Surgery
- Orthopedic Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Tracheal and airway disorders
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Clinical Nutrition and Gastroenterology
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Congenital gastrointestinal and neural anomalies
- Infant Nutrition and Health
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Abdominal Trauma and Injuries
University Medical Center Freiburg
2014-2024
University of Freiburg
2013-2024
Orthopädische Praxis
2019-2024
Ortenau Klinikum
2010-2019
Ludwig-Maximilians-Universität München
2013
GTx (United States)
2013
Offenburg University of Applied Sciences
2008
University of Tübingen
2003
Prosthetic joint infections (PJI) are associated with high morbidity and costs. Various efforts have been made to improve the diagnosis of PJI over past years, but only few studies assessed diagnostic utility nucleic acid amplification test (NAAT) techniques in this context. Here, we report our experience a commercial 16S rRNA gene PCR an automated multiplex-PCR cartridge system identifying pathogens causing PJI.A prospective single-centre study was performed including 54 patients either...
The West Nile Virus (WNV), a member of the family Flaviviridae, is an emerging mosquito-borne flavivirus causing potentially severe infections in humans and animals involving central nervous system (CNS). Due to its tendency, WNV now occurs many areas where other flaviviruses are co-occurring. Cross-reactive antibodies with or vaccination (e.g., tick-borne encephalitis virus (TBEV), Usutu (USUV), yellow fever (YFV), dengue (DENV), Japanese (JEV)) therefore remain major challenge diagnosing...
Restricted use of third-generation cephalosporins and fluoroquinolones has been linked to a reduced incidence hospital-acquired infections with multidrug-resistant bacteria. We implemented an intensified antibiotic stewardship (ABS) programme in the medical service university hospital center aiming at reduction by least 30% these two drug classes. The ABS was focused on 300-bed service. Prescription discouraged, whereas penicillins encouraged. Monthly density measured WHO-ATC defined locally...
Introduction Early initiation of antimicrobial treatment for acute infection is an important task in the emergency department (ED) with a likely impact on hospital-wide antibiotic use pattern. We implemented stewardship (ABS) programme focused non-trauma patients at large university hospital centre targeting broad-spectrum cephalosporin and fluoroquinolone use. Methods Guidelines discussion groups emphasised reduced prescription third-generation cephalosporins fluoroquinolones encouraged...
Tick-borne encephalitis virus (TBEV) is an important central nervous system (CNS) infection in Europe and Asia. It a flavivirus the tick-borne group. Effective vaccines against TBE are available affected countries. However, diagnosing challenging due to cross-reactive antibodies between different viruses of genus
BackgroundThe exact epidemiology of tick-borne encephalitis virus (TBEV) infections is unknown because many TBEV have an influenza-like or asymptomatic course. Surveillance data are based on patients with any (predominantly neurological) symptoms that prompted diagnostic testing. Infection- and vaccine-induced antibodies against can be distinguished using NS1 IgG ELISA.AimIn a seroprevalence study we aimed to investigate antibody prevalence, incidences, manifestation indices potential...
Objective Tick-borne encephalitis (TBE) caused by the tick-borne virus (TBEV) is most important arboviral disease in Europe and Asia. The Upper Rhine Valley thought to be very western border of TBEV distribution Europe. aim our study was identify natural foci isolate from ticks, determine prevalence local tick populations phylogenetic relatedness circulating strains this region. Material methods Ticks were collected between 2016, 2017 2018 flagging. isolated ticks analyses performed. Minimal...
Background Tick-borne encephalitis (TBE) is the most important tick-borne viral disease in Eurasia and causes humans a number of animals, among them dogs horses. There still no good correlation between tick numbers, weather conditions human cases. hypothesis that co-feeding due to simultaneous occurrence larvae nymphs may be factor for increased transmission virus nature disease. Based on long-term data from natural TBEV focus, phylogenetic results meteorological we sought challenge this...
Background: Tickborne-encephalitis (TBE) is a potentially life-threating neurological disease that mainly transmitted by ticks. The goal of the present study to analyze potential uniform environmental patterns identified TBEV microfoci in Germany. results are used calculate probabilities for distribution Germany based on geostatistical model. Methods: We aim consider specification characteristics locations detected using open access epidemiological, geographical and climatological data...
Abstract Background The WHO/ATC (Anatomical Therapeutic Chemical) index DDD (WHO-DDD) is commonly used for drug consumption measurement. Discrepancies between WHO-DDD and actual prescribed daily doses (PDD) in hospitals have prompted alternative dose definitions adapted to recommended hospital practice guidelines [recommended (RDD)]. Methods In order validate RDD we performed modified point prevalence surveys 24 acute care recorded 20620 PDD of antibiotics given 4226 adult patients on the...
Abdominal mesenteritis is a rare and poorly understood gastroenterological disease. Here, we report on two identical cases of Mycobacterium genavense associated retractile in HIV-positive patients. A literature search retrieved only few small retrospective studies, which characterize the clinical course this seldom infection. We propose pathogen-specific syndrome patients linked to infection basis our observation meta-analysis with duodenal wall thickening, central mesenterial mass vascular...
Current guidelines regarding Lyme neuroborreliosis [LNB] require the presence of intrathecal Borrelia burgdorferi-specific antibody production for definite diagnosis LNB. However, about 20% early stage infections present without an elevated index. Moreover, B. burgdorferi specific synthesis may persist long after successful therapy Recently published data indicate that CXCL13 seems to be a promising diagnostic tool In addition, might suitable treatment monitoring. We report on 39-year-old...
Der zunehmende Anteil multiresistenter Erreger ist eines der zentralen Probleme modernen Medizin. Antibiotic-Stewardship-(ABS-)Programme sind wichtige Hilfsmittel, um den Antibiotikaverbrauch einzuschränken und damit Resistenzentwicklung entgegenzuwirken. Eine Anzahl von Kinderkliniken dabei, ABS-Programme zu etablieren, wobei international bisher nur wenige Daten bezüglich Implementierung Effektivität dieser Programme im Bereich Pädiatrie vorliegen. Das Dr. Haunersche Kinderspital eine...
In July 2018, brucellosis was diagnosed in a German patient without travel history to regions endemic for Brucella. Microbiological analysis, including whole-genome sequencing, revealed Brucella suis biovar 1 as the etiologic agent. Core-genome-based multilocus sequence-typing analysis placed isolate close proximity strains originating from Argentina. Notably, despite strong IgM response, did not develop Brucella-specific IgG antibodies during infection. Here, we describe clinical course of...