A5006309408- Viral Infectious Diseases and Gene Expression in Insects
- Protein purification and stability
- MXene and MAX Phase Materials
- Graphene research and applications
- Monoclonal and Polyclonal Antibodies Research
- 2D Materials and Applications
- Microbial Metabolic Engineering and Bioproduction
- Advanced Control Systems Optimization
- Spectroscopy and Laser Applications
- Remote Sensing and LiDAR Applications
- Ferroelectric and Negative Capacitance Devices
- Peptidase Inhibition and Analysis
- Process Optimization and Integration
- Semiconductor Lasers and Optical Devices
- Phase Change Materials Research
- Analytical Chemistry and Chromatography
- Remote Sensing in Agriculture
- Quantum and electron transport phenomena
- Molecular Junctions and Nanostructures
- Solar Thermal and Photovoltaic Systems
- CAR-T cell therapy research
- Microfluidic and Capillary Electrophoresis Applications
- Adsorption and Cooling Systems
- Mineral Processing and Grinding
- Neuropeptides and Animal Physiology
University of Electronic Science and Technology of China
2024
Zhejiang Chinese Medical University
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Harbin Institute of Technology
2024
Hubei University
2024
Ningbo University of Technology
2020-2024
Southwest Minzu University
2022-2024
State Ethnic Affairs Commission
2022-2024
Hebei Agricultural University
2009-2023
MXenes, the new 2D transition metal carbides and nitrides, have recently attracted extensive attention due to their diverse applications excellent performances. However, thermal electrical properties of most MXene materials are yet be studied. In this work, we investigate semiconducting Sc2CT2 (T = F, OH) MXenes using first-principles calculations. Both determined show carrier mobilities. The electron mobility in Sc2CF2 is found strongly anisotropic at room temperature, with values 5.03 ×...
Mo2C, the newly synthesized MXene with a large lateral size and superconductivity property, has attracted increasing interest in material science. Employing first-principles density functional calculations, its intrinsic structural, electrical, thermal, mechanical properties are investigated this work. It is found that nonmagnetic small molar volume. The electrical conductivity predicted order of 106 Ω–1m–1, value significantly influenced by doping. For thermal conductivity, both electron...
The objective of this study is to develop new algorithms for automated urban forest inventory at the individual tree level using LiDAR point cloud data. data contain three-dimensional structure information that can be used estimate height, base crown depth, and diameter. This allows precision down trees. Unlike most published detect trees from a LiDAR-derived raster surface, we worked directly with separate metrics. Testing results in typical forests are encouraging. Future works will...
Endosialin/TEM1 was originally discovered as a human embryonic fibroblast-specific antigen and later found to be differentially expressed in tumor stroma endothelium. overexpression has been observed many cancers of various tissue origin, including colon, breast, pancreatic, lung. The knockout (KO) mouse model showed the absence endosialin/TEM1 expression reduced growth, invasion, metastasis xenografts. In addition, lack led an increase small immature blood vessels decreased numbers medium...
Fibroblast activation protein (FAP) is a serine protease selectively expressed on reactive stromal fibroblasts of epithelial carcinomas. It widely believed to play role in tumor invasion and metastasis therefore represent potential new drug target for cancer. Investigation into its biological function, however, has been hampered by the current unavailability selective inhibitors. The challenge identifying inhibitors that are FAP over both dipeptidyl peptidases (DPPs), with which it shares...
MXenes have attracted intensive attention because of their widespread applications. As a well-studied member the MXene family, Ti2CO2 has been demonstrated to be semiconducting with ultrahigh carrier mobility, acting as candidate material for electronic devices. In this work, influence layer thickness on electrical conductivity is investigated combined first-principles density functional calculations and Boltzmann transport theory. Because interaction-induced band splitting, gap generally...
Recent reports have described several cellular phenotypes that appear to be mediated by Endosialin/TEM-1/CD248 (TEM-1), including tubule formation on matrigel, migration and proliferation. It has been shown siRNA knock-down of TEM-1 in primary human fibroblasts resulted reduced However, the downstream signaling events mediate function(s) currently remain unknown. In this study, we demonstrate mediates proliferation pericytes through a PDGF receptor pathway. Normal expressing high levels were...
Using first-principles calculations, the electronic structures and electron transport properties of zigzag armchair O-functionalized Ti2C MXene nanoribbons are examined in this work. We demonstrate that energy gaps patterned Ti2CO2 can be tuned by appropriate designs crystallographic orientation widths. The along direction with width parameter larger than six show zero or very low band gaps, while opened for armchair-shaped edges. devices various widths investigated using nonequilibrium...
Abstract Myristic acid/expanded graphite (MA/EG) composite phase-change material (CPCM) was prepared by absorbing liquid MA (as the PCM) into EG supporting material). Its chemical structure, microstructure, and thermal properties were characterized studied. In MA/EG CPCM, largest mass content of 93.5% using diffusion–exudation circle method for first time. Fourier transform infrared spectroscopy (FTIR) analysis indicated that a pure physical mixture which structure does not change, they...
Potato early blight and late are devastating diseases that affect potato planting production. Thus, precise diagnosis of the is critical in treatment application management farm. However, traditional computer vision technology pattern recognition methods have certain limitations detection crop diseases. In recent years, development deep learning convolutional neural networks has provided new solutions for rapid accurate this study, an integrated framework combines instance segmentation...
Dipeptidyl peptidase IV (DPP-IV; E.C. 3.4.14.5), a serine protease that degrades the incretin hormones GLP-1 and GIP, is now validated target for treatment of type 2 diabetes. Dipeptide boronic acids, among first, still most potent DPP-IV inhibitors known, suffer from concern over their safety. Here we evaluate potency, in vivo efficacy, safety selected set these inhibitors. The adverse effects induced by acid-based are essentially limited to what has been observed previously non-boronic...
Because of its high mortality rate, ovarian cancer is a leading cause death among women and highly unmet medical need. New therapeutic agents that are effective well tolerated needed antigen-specific monoclonal antibodies have direct pharmacologic effects or can stimulate immunological responses represent promising class for the treatment this disease. The human folate receptor α (FOLR1), which overexpressed in but largely absent normal tissues, appears to play role transformed phenotype...
A free-space communication based on a mid-infrared quantum cascade laser (QCL) is presented. room-temperature continuous-wave distributed-feedback (DFB) QCL combined with detector comprise the basic unit of system. Sinusoidal signals at highest frequency 40 MHz and modulated video carrier 30 were successfully transmitted this experimental setup. Our research has provided proof-of-concept demonstration space optical application QCL. The operation our setup was determined by circuit-limited...
Monitoring the physical or chemical properties of cell broths to infer status is often challenging due complex nature broth. Key factors indicative include density, viability, product leakage, and DNA release fermentation The rapid accurate prediction for hosts with intracellular protein products can minimise loss leakage at onset lysis in fermentation. This article reports rheological examination an industrially relevant E. coli producing antibody fragments (Fab'). Viscosity monitoring...
The phenotypic parameters of crop plants can be evaluated accurately and quickly using an unmanned aerial vehicle (UAV) equipped with imaging equipment. In this study, hundreds images Chinese cabbage (Brassica rapa L. ssp. pekinensis) germplasm resources were collected a low-cost UAV system used to estimate width, length, relative chlorophyll content (soil plant analysis development [SPAD] value). super-resolution generative adversarial network (SRGAN) was improve the resolution original...
Current strategies for the production of therapeutic mAbs include use mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization rodent Abs, or phage libraries. Generation hybridomas secreting has been previously reported; however, this approach not fully exploited immunotherapy development. We reported transient regulation cellular DNA mismatch repair processes enhance traits (e.g., affinity and titers) mAb-producing lines, including...
Over-expression of endosialin/CD248 (herein referred to as CD248) has been associated with increased tumor microvasculature in various tissue origins which makes it an attractive anti-angiogenic target. In effort target CD248, we have generated a human CD248 knock-in mouse line and MORAb-004, the humanized version anti-human antibody Fb5. Here, report that MORAb-004 treatment significantly impacted syngeneic growth metastasis mice. comparison untreated tumors, treated tumors displayed...