A5042303176- Steroid Chemistry and Biochemistry
- Electrochemical Analysis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Pharmacogenetics and Drug Metabolism
- Biochemical effects in animals
- Microbial Metabolic Engineering and Bioproduction
- Advanced oxidation water treatment
- Water Quality Monitoring and Analysis
- Hormonal Regulation and Hypertension
- Neurological Disease Mechanisms and Treatments
- biodegradable polymer synthesis and properties
- Radioactive element chemistry and processing
- Medicinal Plant Extracts Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Enzyme Structure and Function
- Nitric Oxide and Endothelin Effects
- Hemoglobin structure and function
- Advanced Nanomaterials in Catalysis
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Electrochemical sensors and biosensors
- Cannabis and Cannabinoid Research
- Molecular Sensors and Ion Detection
- Vanadium and Halogenation Chemistry
- Neurological Disorders and Treatments
Polish Academy of Sciences
2022-2025
Maj Institute of Pharmacology
2022-2025
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences
2020-2024
Jagiellonian University
2015-2020
Faculty (United Kingdom)
2016
Abstract Oxidative stress and neuroinflammation play a pivotal role in pathomechanisms of brain ischemia. Our research aimed to formulate nanotheranostic system for delivering carnosic acid as neuroprotective agent with anti-oxidative anti-inflammatory properties ischemic tissue, mimicked by organotypic hippocampal cultures (OHCs) exposed oxygen–glucose deprivation (OGD). In the first part this study, nanocarriers were formulated encapsulating two types nanocores (nanoemulsion (AOT)...
Cannabidiol (CBD) appears to possess some neuroprotective properties, but experimental data are still inconsistent. Therefore, this in vitro study aimed compare the effects of CBD a wide range concentrations on oxidative stress and excitotoxic-related cell damage. Results showed that low ameliorated H2O2-evoked damage primary cortical neuronal culture. However, higher alone (5-25 μM) decreased viability neurons concentration-dependent manner aggravated toxic hydrogen peroxide (H2O2)....
3-Ketosteroid Δ
Δ1-Dehydrogenation of 3-ketosteroids catalyzed by flavin adenine dinucleotide (FAD)-dependent 3-ketosteroid dehydrogenases (Δ1-KSTD) is a crucial step in steroid degradation and synthesis several drugs. The catalytic mechanism assumes the formation double bond two steps, proton abstraction tyrosyl ion, rate-limiting hydride transfer to FAD. This hypothesis was never verified quantum-mechanical studies despite contradictory results from kinetic isotope effect (KIE) reported 1960 Jerussi...
The presence of dyes from inter alia textile industry in wastewater, poses a serious threat for the environment. New methods removal persistent dyestuffs effluent streams still attract much attention. In this report application Mn III (TPPS) [where TPPS = 5,10,15,20‐tetrakis(4‐sulfonatophenyl) –21 H,23H‐porphyrin] as suitable catalyst oxidative degradation model substrate, Orange II (ORII), was studied. (TPPS)/H 2 O system found to degrade ORII with high efficiency under ambient conditions...
Mn<sup>III</sup>(TPPS) is oxidized by an excess of hydrogen peroxide in basic aqueous solution to yield Mn<sup>V</sup>(TPPS) and/or Mn<sup>IV</sup>TPPS, and subsequently reduced back reveal redox cycling, catalase degradation activities.
Since the population of Europe is rapidly aging, number cases neurodegenerative diseases sharply increases. One most significant limitations current disease treatment inefficient delivery neuroprotective drugs to affected part brain. promising methods improve pharmacokinetic and pharmacodynamic properties antioxidants their encapsulation in nanocarriers.
New, more efficient methods of wastewater treatment, which will limit the harmful effects textile dyes on natural environment, are still being sought. Significant research work suggests that catalysts based transition metal complexes can be used in and environmentally friendly processes. In this context, a number compounds containing manganese have been investigated. A suitable catalyst should capacity to activate selected oxidant or group oxidants, order industrial oxidation reactions....
The Cover Feature shows a glass reactor in which Orange II (ORII) is degraded by H2O2 basic carbonate buffer solution catalyzed MnIII(TPPS). Under these conditions the catalyst rapidly oxidized to (TPPS)MnV=O, reacts with ORII and returns Typical spectral changes during degradation process (upper LH corner) schematic concentration profiles for all species involved RH are presented. pH dependence of (lower ascribed deprotonation HCO4– MnIII(TPPS)(H2O)(OH), respectively. typical saturation...
3-Ketosteroid Δ1-dehydrogenases (KstD) are important microbial flavin enzymes that initiate the metabolism of steroid ring A and useful find application in synthesis drugs. We present a structure KstD from Sterolibacterium denitrificans (AcmB), which contains previously uncharacterized membrane-associated domain extended proton-relay system. The experimental theoretical studies show 1,2-dehydrogenation proceeds according to Ping-Pong bi-bi kinetics two-step base-assisted elimination (E2cB)...
3-Ketosteroid Δ1-dehydrogenases (KstD) are important microbial flavin enzymes that initiate the metabolism of steroid ring A and find application in synthesis drugs. We present a structure KstD from Sterolibacterium denitrificans (AcmB), which contains previously uncharacterized putative membrane-associated domain extended proton-relay system. The experimental theoretical studies show 1-dehydrogenation proceeds according to Ping-Pong bi-bi kinetics two-step base-assisted elimination (E2cB)...