A5067581075- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Surfactants and Colloidal Systems
- Nanomaterials and Printing Technologies
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Gold and Silver Nanoparticles Synthesis and Applications
- Pickering emulsions and particle stabilization
- Conducting polymers and applications
- Dendrimers and Hyperbranched Polymers
- Nanoparticles: synthesis and applications
- Bone Tissue Engineering Materials
- nanoparticles nucleation surface interactions
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Proteins in Food Systems
- Advanced Sensor and Energy Harvesting Materials
- Polymer Nanocomposite Synthesis and Irradiation
- Quantum Dots Synthesis And Properties
- Polymer composites and self-healing
- Corrosion Behavior and Inhibition
- Nanoplatforms for cancer theranostics
- Mesoporous Materials and Catalysis
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences
2016-2025
Polish Academy of Sciences
2009-2020
Krakow Cardiovascular Research Institute
2020
Maj Institute of Pharmacology
2014
Akademickie Centrum Komputerowe Cyfronet AGH
2010-2012
The aim of our study was to develop a novel method for the preparation polymeric core-shell nanoparticles loaded with various actives biomedical applications. Poly(caprolactone) (PCL), poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) were prepared using spontaneous emulsification solvent evaporation (SESE) method. model active substance, Coumarin-6, encapsulated into formed nanoparticles, then they modified/functionalized by multilayer shells’ formation. Three types multilayered...
The aim of this work was to develop a novel method preparation loaded nanosize capsules based on liquid core encapsulation by biocompatible polyelectrolyte (PE) multilayer adsorption, with or without pegylated outermost layer. Using AOT (docusate sodium salt) as emulsifier, we obtained cores, stabilized an AOT/PLL (poly-l-lysine hydrobromide) surface complex. These positively charged cores were encapsulated layer-by-layer adsorption polyelectrolytes, polyanion PGA (poly-l-glutamic acid...
Nanoemulsion-templated long sustained polyelectrolyte (PE) nanocapsules (average size < 200 nm) loaded with Oil Red O and two cyanine-type photosensitizers: IR-786 IR-780 were successfully fabricated by using the layer-by-layer (LbL) technique. All nanoproducts subjected to in vitro release characteristics analysis of selected control parameters, i.e., type surfactant head group, characteristic time surfactant–polyelectrolyte interactions. Their properties characterized means dynamic light...
The aim of this work was to develop the method preparation loaded, submicron nanocapsules based on liquid core encapsulation by polyelectrolyte (PE) multilayer adsorption. procedure PE adsorption emulsion droplets requires a specific selection surfactants, which have good properties as emulsifiers and provide stable surface charge for sequential without losing stability emulsion. Using AOT emulsifier study obtained droplets, stabilized AOT/PDADMAC complexes. These positively charged cores...
The use of polymeric nanoparticles (NPs) in pharmacology provides many benefits because this approach can increase the efficacy and selectivity active compounds. However, development new nanocarriers requires better understanding interactions between NPs immune system, allowing for optimization NP properties effective drug delivery. Therefore, present study, we focused on investigation biocompatible a murine macrophage cell line (RAW 264.7) human monocytic leukemia (THP-1). based liquid core...
Abstract Oxidative stress and neuroinflammation play a pivotal role in pathomechanisms of brain ischemia. Our research aimed to formulate nanotheranostic system for delivering carnosic acid as neuroprotective agent with anti-oxidative anti-inflammatory properties ischemic tissue, mimicked by organotypic hippocampal cultures (OHCs) exposed oxygen–glucose deprivation (OGD). In the first part this study, nanocarriers were formulated encapsulating two types nanocores (nanoemulsion (AOT)...
The clinical application of paclitaxel (PTX), a widely used anticancer drug, is constrained by cardiac arrhythmias and disruptions in vascular homeostasis. To mitigate the non-specific, high toxicity PTX towards cardiomyocytes, we propose newly synthesized SDS-based polyelectrolyte multicore nanocapsules. This study aims to verify hypothesis that NCs can cytotoxic effects on cells serve as effective nanocarriers for this drug. We investigated two types with differing coatings: poly-L-lysine...
The aim of this work was to develop the method preparation loaded, submicron nanocapsules based on liquid core encapsulation by polyelectrolyte (PE) multilayer adsorption. procedure PE adsorption emulsion droplets requires a specific selection surfactants, which have good properties as emulsifiers and provide stable surface charge for sequential without losing stability emulsion. Using AOT emulsifier study obtained droplets, stabilized AOT/PDADMAC complexes. These positively charged cores...
We validated here the applicability to hyperthermia treatment of magnetic nanocapsules prepared by sequential layer-by-layer adsorption polyelectrolytes and magnetic, Fe3O4 nanoparticles. For shell preparation around a nanodroplet liquid core, biocompatible were used: poly l-lysine as polycation glutamic acid polyanion. The effect was demonstrated applying radio frequency (rf) field with maximum fields H up 0.025 T frequencies 430 kHz; we found sizable heating effects, rate 0.46 °C/min. also...
Background: The functionalization of a nanoparticle surface with PEG (polyethylene glycol) is an approach most often used for extending nanomaterial circulation time, enhancing its delivery and retention in the target tissues, decreasing systemic toxicity nanocarriers their cargos. However, because PEGylated nanomedicines were reported to induce immune response including production anti-PEG antibodies, activation complement system as well hypersensitivity reactions, hydrophilic polymers...