A5088741710- Hepatitis C virus research
- Hepatitis B Virus Studies
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- HIV-related health complications and treatments
- Cardiovascular and exercise physiology
- Gastrointestinal motility and disorders
- Advanced Glycation End Products research
- Hepatitis Viruses Studies and Epidemiology
- Martial Arts: Techniques, Psychology, and Education
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Protein Degradation and Inhibitors
- Blood Pressure and Hypertension Studies
- Dermatology and Skin Diseases
- Acute Lymphoblastic Leukemia research
- Animal Virus Infections Studies
- Cardiovascular Effects of Exercise
- Clinical Nutrition and Gastroenterology
University of Gothenburg
2023
Karolinska Institutet
1986-2017
Karolinska University Hospital
2005-2015
Jewish General Hospital
2009
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT recognize microbial riboflavin metabolites from range of microbes presented by MR1 molecules. are impaired several chronic diseases including HIV-1 infection, where they show signs exhaustion and decline numerically. Here, we examined the broader effector functions this context strategies to rescue their functions. Residual HIV-infected patients...
Abstract Background Innate immune responses to conserved microbial products such as lipopolysaccharide ( LPS ) and flagellin are likely important in microbial–host interactions intestinal homeostasis. We hypothesized that bacterial translocation activation of mucosal immunity against common antigens might be involved the development irritable bowel syndrome IBS ). therefore compared serum levels , soluble CD 14 sCD 14), antibodies between patients with different subtypes healthy controls....
Objective: To investigate plasma levels of high mobility group box-1 protein (HMGB1), a marker tissue necrosis and immune activation, as well lipopolysaccharide (LPS), bacterial translocation, in HIV-1-infected patients. Design: We studied 32 HIV-1-positive patients who had responded to antiretroviral therapy with undetectable viremia after 2 years, 10 nonresponders 19 healthy controls. Methods: HMGB1 was analyzed by ELISA, LPS Lamilus colometric assay. Nonparametric statistics were applied....
The hepatitis B virus (HBV) core antigen (HBcAg) has a unique ability to bind high frequency of naive human and murine cells. role HBcAg-binding cells in the immunogenicity HBcAg is not clear. properties were characterized using particles with mutated spike region (residues 76–85) sequences. Deletion residues 76–85 (HBcΔ76–85) destroyed cell binding, whereas deletion 79–85 did not. an Ile instead natural Ala at position 80 cells, reversion Ile80→Ala restored binding. Destroying cell-binding...
A key question in the development of a therapeutic vaccine against hepatitis C virus (HCV) is whether vaccine-primed T cells enter liver and eliminate HCV-expressing hepatocytes. In absence an infectious small-animal model, we evaluated homing mice with transient hepatic transgene expression HCV nonstructural 3/4A (NS3/4A) protein. We found that primed by transdermal DNA-based vaccination entered cleared NS3/4A-expressing hepatocytes transiently transgenic CD8(+/+) but not CD8(-/-) mice....
Objectives We investigated whether there are differences in the effects on microbial translocation (MT) and enterocyte damage by different antiretroviral therapy (ART) regimens after 1.5 years antibiotic use has impact MT. In a randomized clinical trial (NCT01445223) first line ART, patients started either lopinavir/r (LPV/r) (n = 34) or efavirenz (EFV) containing ART 37). Lipopolysaccharide (LPS), sCD14, anti-flagellin antibodies intestinal fatty acid binding protein (I-FABP) levels were...
Physiological and morphological characteristics of world class epee fencers were analysed. The results showed that épée have a high maximal aerobic power isometric dynamic strength. movement pattern fencing in an asymmetry the body. Thus, weapon hand elbow flexion forward leg muscle strength higher than contralateral extremity. Finally, mass - evaluated from computed tomography was while fiber composition not different leg.
Background Microbial translocation (MT) contributes to immune activation during HIV and HCV infections. We investigated the kinetics of MT markers anti-HCV anti-HIV treatments, if baseline plasma levels lipopolysaccharide (LPS), binding protein (LBP) soluble CD14 (sCD14) could predict treatment outcome. Methods Plasma from 78 HIV-infected patients was evaluated for LPS, LBP sCD14. The starting (with ongoing antiretroviral (ART) treatment) were categorized into sustained viral responders...
The purpose of this study was to evaluate the effect long-term anemia and subsequent retransfusion erythrocytes on various circulatory parameters. Anemia induced in nine healthy male subjects by repeated venesections. stored blood retransfused after 9 wk (range 8–11 wk). Exercise tests were performed before venesection control state (C), anemic (A), 48 h (R). Hemoglobin concentration levels 146 +/- 10 g/l C, 110 7 A, 145 R. Maximal O2 uptake 4.55 0.6, 3.74 0.7, 4.45 0.6 l/min R,...
Hepatitis B virus core antigen (HBcAg) is thought to be a major target for specific cytotoxic T cells (CTLs) in hepatitis infections. A single dose of C nonstructural 3/4A DNA (<5 microg) effectively primes functional CTLs, independently CD4(+) helper and by different routes immunization. In contrast, HBcAg-specific CTL priming was cell dependent highly sensitive the route delivery. Although improved 10-fold codon optimization vivo electroporation, low levels still failed prime CTLs...
The IL-28 gene is associated with sustained viral response (SVR) after treatment peg-IFN and ribavirin in liver transplant recipients chronic hepatitis C genotype 1 infection. We analysed the importance of recipient donor IL-28B for to fibrosis progression 54 recipients. Fibrosis stage (F) was defined as mild when F≤2 severe F≥3 a biopsy or according elasticity analysis. found significantly lower prevalence SNP CC (22%) than donors (67%), P<0.0001. SVR seen 61% 27% pretreatment, P=0.01....
Summary. In order to evaluate a computerized modified acetylene rebreathing method for the determination of cardiac output, 15 healthy subjects were studied at different levels their maximal oxygen uptake ( V̇ o 2max ). Submaximal exercise was performed on cycle ergometer and treadmill. Oxygen uptake, heart rate, output (acetylene method) determined in all test situations. seven simultaneous determinations made by Q̇ A ) dye dilution D Furthermore, new resting technique used. The...
To study the hepatitis B-specific T cell-mediated immune response in chronically infected children and adolescents.In all, 36 HBsAg-positive patients, 2 to 19 years old, were included. There 9 HBeAg-positive patients with normal levels of alanine aminotransferase (ALT) (group 1), 18 elevated ALT 2), HBeAg-negative, anti-HBe-positive 3). Four group treated interferon during study. In all HBcAg-specific cell proliferation prospectively studied repeated samples for a mean follow-up time 1.6...
Single genetic nucleotide polymorphism (rs12979860) near the gene for interleukin 28B (IL28B) is known to be of importance frequency spontaneous clearance and treatment outcome in interferon-based therapies patients with hepatitis C virus (HCV) infection. The aim present study was investigate whether IL28B children and/or their mothers plays a role vertical transmission HCV (HCV-VT).Plasma samples from 59 infected women, 76 uninfected born mothers, 47 vertically transmitted infection, were...