A5056998012- Organic Electronics and Photovoltaics
- Glycosylation and Glycoproteins Research
- Organic Light-Emitting Diodes Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Immunotherapy and Immune Responses
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
- Photochromic and Fluorescence Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Thin-Film Transistor Technologies
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Perovskite Materials and Applications
- Lipid Membrane Structure and Behavior
- Carbohydrate Chemistry and Synthesis
- RNA Interference and Gene Delivery
- Advanced Biosensing Techniques and Applications
- Peptidase Inhibition and Analysis
- Molecular Sensors and Ion Detection
- Photochemistry and Electron Transfer Studies
- Molecular Junctions and Nanostructures
- Strong Light-Matter Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Escherichia coli research studies
Max Planck Institute of Colloids and Interfaces
2017-2023
University of Vienna
2021-2023
Max Perutz Labs
2022-2023
The University of Queensland
2015-2021
Brisbane School of Theology
2020
Freie Universität Berlin
2018
Max Planck Society
2017
University of Potsdam
2011-2015
Abstract The rapid development of charge transporting and light‐emitting organic materials in the last decades has advanced device performance, highlighting high potential transistors (LETs). Demonstrated for first time over 15 years ago, LETs have transformed from an optoelectronic curiosity to a serious competitor race cheaper more efficient displays, also showing promise injection lasers. Thus, what is LET, how does it work, are current challenges its integration into mainstream...
A solution-processable dibromoindigo with an alkyoxyphenyl solubilizing group is developed and used as a new electron acceptor in organic photodiodes. The solution-processed fullerene-free photodiodes show almost spectrally flat response high responsivity (0.4 W(-1)) detectivity (1 × 10(12) Jones). These values are comparable to silicon-based
Abstract Over the years, achieving efficient electroluminescence (EL) while simultaneously having low light amplification thresholds under optical excitation has been key to progression toward long‐thought objective of electrically pumped organic lasers. While significant progress in this regard made for semiconductors emitting blue–green region visible spectrum, laser dyes with low‐energy emission (>600 nm) still suffer from high amplified spontaneous (ASE) and external quantum...
Abstract DC‐SIGN is a cell‐surface receptor for several pathogenic threats, such as HIV, Ebola virus, or Mycobacterium tuberculosis . Multiple attempts to develop inhibitors of the underlying carbohydrate–protein interactions have been undertaken in past fifteen years. Still, drug‐like ligands are sparse, which most likely due its hydrophilic, solvent‐exposed carbohydrate‐binding site. Herein, we report on parallel fragment screening against applying SPR and reporter displacement assay,...
Two non‐single‐crystal high‐mobility single‐layer light‐emitting field‐effect transistors (LEFETs) exhibiting narrow UV and deep‐blue emission are described. The organic semiconductors based on a [1]benzothieno[3,2‐b][1]benzothiophene (BTBT) scaffold achieve charge carrier mobilities of 2 6 cm V −1 s , respectively. general applicability BTBT‐C10 as an excellent semiconductor for LEFETs is then demonstrated in conventional heterostructure LEFETs. Here it acts thin layer underneath blue,...
Organic light emitting field effect transistors (LEFETs) integrate emission of a diode with logic functions transistor into single device architecture. This integration has the potential to provide simplified displays at low costs and access injection lasing. However, charge carrier mobility in LEFETs is limiting factor realizing high current densities along trade-off between brightness efficiency. Herein, we present technique controlling nanoscale morphology semiconducting polymers using...
Abstract Light‐emitting field‐effect transistors (LEFETs) are an emerging type of devices that combine light‐emitting properties with logical switching function. One the factors limiting their efficiency stems from spin statistics electrically generated excitons. Only 25% them, short lived singlet states, capable light emission, other 75% being long triplet states wasted as heat due to spin‐forbidden processes. Traditionally, way overcome this limitation is use phosphorescent materials...
A see-through organic light emitting field-effect transistor (LEFET) is realized by using a highly transparent, high mobility material. Low voltage operated LEFETs with increased optical and electrical characteristics are shown. As service to our authors readers, this journal provides supporting information supplied the authors. Such materials peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing...
Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in cell. These glycan-lectin communication complex difficult to analyze. However, quantitative data with single-cell resolution provide means disentangle associated signaling cascades. We chose C-type lectin receptors (CTLs) expressed immune cells as a model system study their capacity transmit of...
Abstract Previously, [1,3]dioxolo[4,5‐ f ][1,3]benzodioxole (DBD)‐based fluorophores used as highly sensitive fluorescence lifetime probes reporting on their microenvironmental polarity have been described. Now, a new generation of DBD dyes has developed. Although they are still to polarity, in contrast the former dyes, extraordinary spectroscopic properties even aqueous surroundings. They characterized by long lifetimes (10–20 ns), large Stokes shifts (≈100 nm), high photostabilities, and...
Abstract Single glycan–protein interactions are often weak, such that glycan binding partners commonly utilize multiple, spatially defined sites to enhance avidity and specificity. Current array technologies usually neglect multivalent display. Laser‐based synthesis technology allows for flexible rapid on‐surface of different peptides. By combining this technique with click chemistry, neo‐glycopeptides were produced directly on a functionalized glass slide in the microarray format. Density...
Dendritic cells (DC) are antigen-presenting coordinating the interplay of innate and adaptive immune response. The endocytic C-type lectin receptors DC-SIGN Langerin display expression profiles restricted to distinct DC subtypes have emerged as prime targets for next-generation immunotherapies anti-infectives. Using heteromultivalent liposomes copresenting mannosides bearing aromatic aglycones with natural glycan ligands, we serendipitously discovered striking cooperativity effects DC-SIGN+...
Laser-induced forward transfer (LIFT) is a rapid laser-patterning technique for high-throughput combinatorial synthesis directly on glass slides. A lack of automation and precision limits LIFT applications to simple proof-of-concept syntheses fewer than 100 compounds. Here, an automated instrument reported that combines laser robotics parallel in microarray format with up 10 000 individual reactions cm-2 . An optimized pipeline amide bond formation the basis preparing complex peptide...
Fragment-based drug discovery is a powerful complement to conventional high-throughput screening, especially for difficult targets. Screening low-molecular-weight fragments usually requires highly sensitive biophysical methods, because of the generally low affinity identified ligands. Here, we developed cell-based fragment screening assay (cellFy) that allows identification hits in physiologically more relevant environment, contrast isolated target screenings solution. For this,...
The C-type lectin receptor Langerin is a glycan-binding protein that serves as an uptake on Langerhans cells and essential for the formation of Birbeck granules. Whereas most ligands are recognized by canonical Ca2+ -dependent binding site, heparins have been proposed to make additional contacts secondary, -independent site. Glycan array screening biomolecular NMR spectroscopy were employed investigate molecular mechanism these interactions. We observed heparin hexasaccharides secondary site...
Color purity is a critical prerequisite for full color displays. Creation of deep-red phosphorescent materials with high PLQYs particularly challenging because the "energy gap law". Simultaneously achieving yielding solution processable Pt(II) complexes further complicates this challenge. In report, we developed high-yielding synthetic route to processable/deep-red complex rigid tetradentate structure, in which identified an octahedral Pt(IV) as major side product formed under standard...
We combine multivalent presentation of glycan ligands on sequence-defined oligo(amidoamines) and liposomes to achieve high avidity targeting galectin-3.
Two new heteroleptic Pt(II) complexes bearing an n ‐hexyloxy substituted phenyllepidine‐based ligand and either a picolinate (pic) or acetylacetonate (acac) coligand are synthesized for use in organic light‐emitting field‐effect transistors (LEFETs). Both compounds obtained good yields via short straightforward synthetic route. It is found that while both show chemical stability solubility, the affects photoluminescence quantum yield crystal packing of complexes. Although aggregate induced...
Immune modulating therapies and vaccines are in high demand, not least to the recent global spread of SARS-CoV2. To achieve efficient activation immune system, professional antigen presenting cells have proven be key coordinators such responses. Especially targeted approaches, actively directing antigens specialized dendritic cells, promise more effective accompanied by reduced payload due less off-target effects. Although antibody glycan-based targeting receptors on been employed, these...
Among contemporary semiconductors, many of the best performing materials are based on [1]benzothieno[3,2- b][1]benzothiophene (BTBT). Alkylated derivatives these small molecules not only provide high hole mobilities but also can be easily processed by thermal vacuum or solution deposition methods. Over last decade, numerous publications have investigated molecular structures and charge transport properties to elucidate what makes so special. However, race toward ever higher resulted in...