A5031406198- Boron Compounds in Chemistry
- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Advanced Condensed Matter Physics
- Topological Materials and Phenomena
- Radioactive element chemistry and processing
- Orthopedic Infections and Treatments
- Organoboron and organosilicon chemistry
- Synthesis and characterization of novel inorganic/organometallic compounds
- Medical Imaging Techniques and Applications
- Enzyme Structure and Function
- Coordination Chemistry and Organometallics
- Iron-based superconductors research
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- RNA Interference and Gene Delivery
- Nuclear Materials and Properties
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Luminescence and Fluorescent Materials
- Rare-earth and actinide compounds
- Pharmacological Effects of Natural Compounds
Zhejiang University
2022-2025
The salt metathesis reaction involving a diamine-based antimony chloride precursor with sodium arsaethynolate in the presence of PMe3 leads to formation stibanyl-functionalized PMe3-arsinidene (2). Detailed analyses through single-crystal X-ray diffraction and density functional theory 2 confirm covalent Sb-As bonds reveal its polarized nature multiple-bond character. In contrast complex 2, substituting xylyl isocyanide or 1,3-diisopropyl-4,5-dimethyl-imidazolin-2-ylidene (IiPr) produces an...
A σ,π-bis(copper) actylide complex, (CB11H11-12-C≡C)Cu2(PiPr3)3 (2), enables the formation of regioselective 1,4-disubstituted 1,2,3-triazoles containing monocarborane anion [CB11H12]- via CuAAC with organic azides under mild conditions. This mothod achieves 1,2,3-triazolylated monocarboranes...
Template-directed self-assembly has proven to be an extremely effective method for the precise fabrication of biomacromolecules in natural systems, while artificial template-directed systems preparation highly intricate molecules remain a great challenge. In this article, we report porphyrin nanorings with different cavity sizes from tetraaldehyde-derived Zn(ii) and diamine precursor through imine condensation reaction. Up 9 or 18 self-assemble together produce triporphyrin nanoring...
We report the first crystal structure of heteroleptic Grignard reagent
Dotinurad, a novel selective urate reabsorption inhibitor, was studied for preformulation beneficiation by supramolecular methods. Two polymorphic forms (form I, form II), monohydrate, and four solvates were prepared characterized single-crystal X-ray diffraction, powder thermal analysis, which enabled the respective molecular conformation, intermolecular interactions, packing arrangements to be determined. Combined with Hirshfeld surface analysis energy networks, stability conformations of...
Baloxavir marboxil (BXM) is a new blockbuster FDA-approved anti-influenza virus agent. However, its poor solubility has limited oral bioavailability. In this study, BXM was crystallized from several organic solvents, obtaining three polymorphs, and their dissolution behaviors were studied. Detailed crystallographic examination revealed that Form I monoclinic, space group P21, with unit cell parameters = 7.1159 (3) Å, b 20.1967 (8) c 9.4878 (4) β 109.033 (1)°, V 1289.02 (9) Å3, Z 2, II 7.1002...
Avatrombopag maleate (AVAT), a second-generation oral thrombopoietin (TPO) receptor agonist, is currently in development for the therapeutic management of thrombocytopenia. The present study introduces novel comparative analysis that elucidates intricate relationship between crystallographic structures and diverse physicochemical properties inherent to complex polymorphic forms (AVA) maleic salt. Seven solid-state forms, including two (AVAT-B, AVAT-C), new trihydrate (AVAT-3H), four solvates...
Rotaxanes have demonstrated great potential in the development of smart materials owing to their attractive dynamic and movable properties. However, it remains a significant challenge construct polymers with outstanding mechanical performance by introduction rotaxane units. Here, we synthesized several pillar[5]arene-based [2]rotaxanes condensation reaction 1-naphthyl isocyanate alkyl diamines introduced them into covalent through ring-opening metathesis polymerization. The rigid bulky...
Abstract The synthesis of monocarborane sulfonamides is reported. methodology relies on coupling the anionic {CB 11 } boron cluster to sulfonyl azides. Under rhodium catalysis and with assistance a pyridine or pyrimidine directing group at C1 position, undergoes B−H activation. Conditions have been identified that lead B2‐selective mono‐sulfonamidation concomitant loss N 2 . protocol requires no additional ligand, oxidant base enables B−N bond formation various azide inputs. new products...