A5042347518- SARS-CoV-2 and COVID-19 Research
- Genetic Associations and Epidemiology
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- PARP inhibition in cancer therapy
- Chronic Lymphocytic Leukemia Research
- interferon and immune responses
- Protein Degradation and Inhibitors
- Calcium signaling and nucleotide metabolism
- Healthcare cost, quality, practices
- Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 detection and testing
- Nutrition, Genetics, and Disease
- Peptidase Inhibition and Analysis
- Head and Neck Cancer Studies
- COVID-19 epidemiological studies
- RNA modifications and cancer
- Clinical Reasoning and Diagnostic Skills
- HIV/AIDS drug development and treatment
- Influenza Virus Research Studies
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
Grail (United States)
2024
Menlo School
2024
Illumina (United States)
2023
Utah College of Applied Technology
2021-2022
Roswell Park Comprehensive Cancer Center
2007-2019
Abstract Human infection with SARS-CoV-2, the causative agent of COVID-19, leads to a remarkably diverse spectrum outcomes, ranging from asymptomatic fatal. Recent reports suggest that both clinical and genetic risk factors may contribute COVID-19 susceptibility severity. To investigate factors, we collected over 500,000 survey responses between April May 2020 accompanying data AncestryDNA database. We conducted sex-stratified meta-analyzed genome-wide association studies (GWAS) for...
Selection pressure due to exposure infectious pathogens endemic Africa may explain distinct genetic variations in immune response genes. However, the impact of those on human immunity remains understudied, especially within context modern lifestyles and living environments, which are drastically different from early humans sub Saharan Africa. There few data population differences constitutional environment, where ancestry environment likely two primary sources variation. In a study...
CD38 has emerged as a high-impact therapeutic target in multiple myeloma, with the approval of daratumumab (anti-CD38 mAb). The clinical importance patients chronic lymphocytic leukemia (CLL) been known for over 2 decades, although it's relevance CLL remains understudied.We investigated biological effects and antitumor mechanisms engaged by primary cells. Besides its immune-effector (antibody-dependent cell-mediated cytotoxicity, complement-dependent death, antibody-dependent cellular...
Reproductive aging phenotypes, including age at menarche (AM) and natural menopause (ANM), are well-established risk factors for breast cancer. In recent years, many genetic variants have been identified in association with AM ANM genome-wide studies among European populations. Using data from the Women's Circle of Health Study (WCHS) 1,307 European-American (EA) 1,365 African-American (AA) cancer cases controls, we aimed to replicate 53 earlier GWAS AA EA groups perform analyses on total...
Summary CD38 is expressed on Waldenström macroglobulinaemia (WM) cells, but its role as a therapeutic target remains undefined. With recent approval of the anti‐CD38 monoclonal antibody, daratumumab (Dara), we hypothesized that blocking would be lethal to WM cells. In vitro Dara treatment cells (including ibrutinib‐resistant lines) elicited antibody‐dependent cellular cytotoxicity (ADCC), complement‐dependent (CDC), cell phagocytosis (ADCP) and direct apoptosis. vivo , was well tolerated...
Abstract Coronavirus disease 2019 (COVID-19) and influenza are respiratory illnesses caused by the severe acute syndrome coronavirus 2 (SARS-CoV-2) viruses, respectively. Both diseases share symptoms clinical risk factors 1 , but extent to which these conditions have a common genetic etiology is unknown. This partly because host well characterized for COVID-19 not influenza, with largest published genome-wide association studies including >2 million individuals about 1,000 3–6 Shared...
The enormous toll of the COVID-19 pandemic has heightened urgency collecting and analysing population-scale datasets in real time to monitor better understand evolving pandemic. objectives this study were examine relationship risk factors susceptibility severity develop models accurately predict outcomes using rapidly obtained self-reported data.A cross-sectional study.AncestryDNA customers USA who consented research.The AncestryDNA Study collected survey data on symptoms, outcomes,...
INTRODUCTION PARAGRAPH Multiple large COVID-19 genome-wide association studies (GWAS) have identified reproducible genetic associations indicating that some infection susceptibility and severity risk is heritable. 1-5 Most of these ascertained cases in medical clinics hospitals, which can lead to an overrepresentation with severe outcomes, such as hospitalization, intensive care unit admission, or ventilation. Here, we demonstrate the utility validity deep phenotyping self-reported outcomes...
To help determine the unmet need for improved diagnostic tools to evaluate patients with nonspecific signs and/or symptoms (NSSS) and suspicion of cancer, we examined patient characteristics, journey, cancer incidence NSSS within The US Oncology Network (The Network), a secondary care community oncology setting. This retrospective, observational cohort study included aged ≥40 years ≥1 in their problem list at first visit (the index date) between 1 January 2016 31 December 2020. Patients were...
ABSTRACT Background The enormous toll of the COVID-19 pandemic has heightened urgency collecting and analyzing population-scale datasets in real time to monitor better understand evolving pandemic. Methods AncestryDNA Study collected self-reported survey data on symptoms, outcomes, risk factors, exposures for over 563,000 adult individuals U.S. just under four months, including 4,700 cases as measured by a positive test. Results We replicated previously reported associations between several...
Abstract Of the >1.6 million people diagnosed with cancer in US each year, >60% are after symptomatic presentation, including nonspecific s/sx. These s/sx may cause pts to undergo unnecessary diagnostic evaluation while possibility of and search for its origin is explored, causing delayed treatment poor outcomes. Additionally, who do not have often subjected various undirected/misdirected procedures due initial suspicion. Our objective was examine pt characteristics, journey,...
Abstract The two main hormonal events of a woman's life, menarche and menopause, have paramount impact on the duration exposure to estrogen. Reproductive aging phenotypes, including age at (AM) natural menopause (ANM) been consistently associated with breast cancer risk. Despite an estimated strong genetic component, genome-wide association studies (GWAS) for AM ANM found that common variants identified date account only 7.4% SNPs related 2.5-4.1% ANM. As most previous GWAS were conducted in...