A5041523691- Phytochemicals and Antioxidant Activities
- Phytochemistry Medicinal Plant Applications
- Natural Antidiabetic Agents Studies
- Bee Products Chemical Analysis
- Phytochemistry and Biological Activities
- Phytochemistry and biological activity of medicinal plants
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Botanical Research and Applications
- Agricultural and Food Sciences
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Reproductive biology and impacts on aquatic species
- Hibiscus Plant Research Studies
- Piperaceae Chemical and Biological Studies
- Child Nutrition and Water Access
- Cassava research and cyanide
- Biochemical Acid Research Studies
- Ginkgo biloba and Cashew Applications
- Synthesis and Biological Evaluation
- Natural product bioactivities and synthesis
- Retinoids in leukemia and cellular processes
- Amoebic Infections and Treatments
- Insect Utilization and Effects
Universidade Federal do Amazonas
2016-2025
Biolog (United States)
2025
The chemical complexity of natural products, such as Eugenia punicifolia (Kunth) DC. plant, presents a challenge when extracting and identifying bioactive compounds. This study investigates the impact different extraction systems seasonal variations on profile pharmacological potential E. leaves using NMR spectroscopy for analysis canonical correlation (CCA) bioactivity correlation. Extracts obtained with methanol (M), ethanol (E), methanol/ethanol (1:1, ME), methanol/ethanol/water (3:1:1,...
The larvicidal effect of dillapiole and its semi-synthetic derivatives on Aedes aegypti (Ae. Aegypti), the main transmitter arboviruses such as dengue (DENV), Zika (ZIKV), Chikungunya (CHIKV), is well - established. Among derivatives, n-butyl ether stands out attributed to significant potential against Ae. aegypti. However, studies are needed assess adverse risk following exposure this chemical non-target organisms. aim study was examine toxic consequences (DBE) by determining...
Abstract Introduction In Brazil, the plant group popularly known as “pedra‐ume‐caá” is used in folk medicine for treatment of diabetes, and its raw material commonly sold. Objective The aim study was to apply a method chemical identification extracts dry pedra‐ume‐caá leaves using HPLC–high‐resolution mass spectrometry (HRMS) NMR develop multivariate model with data authenticate commercial samples. addition, evaluate biological activities extracts. Materials Methods Dry Myrcia multiflora ,...
Species of Eugenia have been used as an antidiabetic natural source. Chemical, antioxidant and antiglycant screening extracts from pedra-ume caá (Eugenia punicifolia) fruits were performed. 1H NMR assisted by non-supervised chemometric methods employed for the evaluation chemical profiles which distinguished according to color fruit maturation stages, well pulp seed fruit. Furthermore, fingerprint analysis crude extract allowed identification quercitrin myricitrin, beside other nine...
This study aimed to evaluate the hypoglycemic effect, antioxidant, α-glucosidase and lipase inhibitory activity, cytotoxicity of Cassia grandis nanodispersion (CgND).The effect was evaluated in alloxan-induced diabetic mice. The particle size, polydispersion index, ζ-potential, conductivity, as well drug-loaded content, were monitored shelf-live, along a year. delivery profile simulated intestinal fluids at pH 6.5 7.4. antioxidant DPPH ABTS inhibition. murine activity lipase-inhibitory...
Bacuri, ingá, and uchi are Amazon fruits consumed specially in the North region of Brazil. Due to their large consumption lack knowledge regarding its chemical composition, these were studied relation Antioxidant constitution. The total phenolic content ranged from 3.86 ± 0.47 33.38 1.51 mg GAE/100 g, flavonoid 1.75 0.22 19.44 0.87 QUERE/100 where contents showed a significant correlation with DPPH ABTS antioxidant assays. Thus, UHPLC-MS/MS was applied do quantify selected compounds, been...
ABSTRACT Virola venosa, popularly known in Brazil as ucuuba-da-mata, occurs naturally the Amazon region and has potential to provide useful natural compounds, already for other species. Therefore, objective of this study was determine chemical composition bark leaf extracts V. test antioxidant capacity α-glucosidase inhibition their compounds. Polar showed be more active both assays, therefore a bioactivity-guided fractionation performed identify compounds that were responsible recorded...
Species of the Byrsonima genus are widely used in Brazil, especially for treatment gastrointestinal disorders. However, species from Amazonian region still poorly studied. Thus, we studied antioxidant, antinociceptive, and anti‐inflammatory activities species, crispa , duckeana garcibarrigae incarnata . Phenolic composition was determined by chemical chromatographic methods. The aqueous extracts were evaluated DPPH • ABTS +• superoxide (O 2 •− ) tests, LPS‐activated macrophage assay,...
Abstract Objective The Amazon has a rich biodiversity where many different plant species can be found. This diversity is an important source of bioactive substances, mainly due to the structural components their phytometabolites. Research for natural products strategy development new agents in therapeutic applications, especially cosmetic that have better pharmacological potential. Within this perspective, objective study was investigate application (anti‐aging potential) stem‐bark extract...
Diabetes mellitus is a chronic metabolic disease that mainly characterized by hyperglycemia. Chalcones and their derivatives have demonstrated promising pharmacological potential for the treatment of diabetes. The aim study was to evaluate antidiabetic activities analyze 4-methoxychalcone (MPP) using GC-MS. compound mass spectroscopy, nuclear magnetic resonance headspace with gas chromatography coupled spectrometry (HS-GC-MS). MPP evaluated via inhibition alpha-glucosidase enzyme, cell...
Aedes aegypti is currently controlled with synthetic larvicides; however, mosquitoes have become highly resistant to these larvicides and difficult eradicate. Studies shown that insecticides derived from fungal extracts various mechanisms of action reduce the risk resistance in mosquitoes. One possible mechanism uncontrolled production reactive oxygen species (ROS) larvae, which can cause changes at cellular level. Thus, crude extract Xylaria sp. was evaluated investigate oxidative effect...
Bertholletia excelsais native to the Amazon Rainforest and is popularly known as Brazil nut. It has socioeconomic importance due its nuts being a great export product. There are fewstudies in literature regarding biotechnological potential of bark, although it used folk medicine. The aim this study was determine chemical constituents, anti-inflammatory antioxidant properties B. excelsabark extract(BEB). Twelve substances were identified by LC/MS/MS, cytotoxicity tests carried out, well...
ABSTRACT Many foods interact with drugs and may cause changes in the pharmacological effects of co-administered therapeutic agent. The enzyme CYP3A4, which belongs to cytochrome P450 complex, is responsible for metabolism most currently on market involved many drug interactions. Hence, interaction this juices some fruits, such as grapefruit, can affect pharmacokinetics various drugs. However, native fruits from Amazon region have not yet been target type research. We determined total...
Oxidative stress is one of the main causes loss sperm function during chilled storage. The aim current study was to evaluate effects a fructose-based extender, which supplemented with catalase or uric acid, on motility, viability, morphological integrity, and lipid peroxidation (LPO) Colossoma macropomum spermatozoa. Sperm diluted in extenders containing (0; 0.1; 0.8; 1.5 kU/L) acid 0.25; 0.5; 1.0 mmol/L) then stored at 4.3 ± 0.6°C for 96 hours. chilling storage time had more significant...
Diabetes, obesity, and their associated metabolic disorders are public health problems that require prevention new efficient drugs for treatment. We evaluated the anti-hyperglycemic, lipid-lowering, anti-obesity effects of semisynthetic α, β-amyrenones (ABA).BALB/c mice were used performing an acute model oral carbohydrate triglyceride tolerance, in a streptozotocin-induced diabetes model, where glycemia body weight changes measured during ten days. C57BL/6 strain diet-induced obesity...
Byrsonima sp é um gênero de árvores endêmico do estado Amazonas, Brasil, com conhecimento farmacológico e químico pouco compreendido. Para investigar o potencial antiinflamatório, cicatrizante antioxidante, as cascas caule quatro espécies (Byrsonima incarnata, duckeana, crispa garcibarrigae) foram analisadas quanto aos seus extratos acetato etila metanólico obtidos por maceração submetidos a análises químicas in vitro. testes diferentes linhagens celulares. Todos os apresentaram atividade...
Introduction:Byrsonima garcibarrigae is an endemic tree of Amazonas state, Brazil, with pharmacological and chemical knowledge poorly understood. Aim: To investigate the antidiabetic potential B. stem bark. Methods: The bark was sequentially extracted by maceration hexane (EHBG), ethyl acetate (EABG), methanol (EMBG). antioxidant capacity, α-glucosidase inhibitory potentials anti-glycation capacities were evaluated. A bio-guided fractionation gave compounds that characterized MS NMR....